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Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms

Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms AbstractNeisseria gonorrhoeae displays considerable potential for antigenic variation as shown in human experimental studies. Various surface antigens can change either by antigenic variation using RecA-dependent recombination schemes (e.g. PilE antigenic variation) or, alternatively, through phase variation (on/off switching) in a RecA-independent fashion (e.g. Opa and lipooligosaccharide phase variation). PilE antigenic variation has been well documented over the years. However, with the availability of the N. gonorrhoeae FA1090 genome sequence, considerable genetic advances have recently been made regarding the mechanistic considerations of the gene conversion event, leading to an altered PilE protein. This review will compare the various models that have been presented and will highlight potential mechanistic problems that may constrain any genetic model for pilE gene variation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png FEMS Microbiology Reviews Oxford University Press

Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms

FEMS Microbiology Reviews , Volume 33 (3) – May 6, 2009

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References (96)

Publisher
Oxford University Press
Copyright
© 2009 Federation of European Microbiological Societies.
ISSN
0168-6445
eISSN
1574-6976
DOI
10.1111/j.1574-6976.2009.00171.x
pmid
19396954
Publisher site
See Article on Publisher Site

Abstract

AbstractNeisseria gonorrhoeae displays considerable potential for antigenic variation as shown in human experimental studies. Various surface antigens can change either by antigenic variation using RecA-dependent recombination schemes (e.g. PilE antigenic variation) or, alternatively, through phase variation (on/off switching) in a RecA-independent fashion (e.g. Opa and lipooligosaccharide phase variation). PilE antigenic variation has been well documented over the years. However, with the availability of the N. gonorrhoeae FA1090 genome sequence, considerable genetic advances have recently been made regarding the mechanistic considerations of the gene conversion event, leading to an altered PilE protein. This review will compare the various models that have been presented and will highlight potential mechanistic problems that may constrain any genetic model for pilE gene variation.

Journal

FEMS Microbiology ReviewsOxford University Press

Published: May 6, 2009

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