Physical Activity Status, But Not Age, Influences Inflammatory Biomarkers and Toll-Like Receptor 4

Physical Activity Status, But Not Age, Influences Inflammatory Biomarkers and Toll-Like Receptor 4 Background. Chronic inflammation has been implicated in the development of cardiovascular disease, diabetes mellitus, cachexia, and osteoporosis. Regular physical activity has been purported to possess “anti-inflammatory” properties which may limit chronic inflammation. Recently, we hypothesized that toll-like receptor 4 (TLR4) may play a role in activity-induced modulation of inflammation. Therefore, the purpose of this study was to determine the association between age, physical activity status, biomarkers of inflammation, and TLR4. Methods. Male and female participants ( n = 84) were recruited to fill one of the following groups: young (18–30 years), active; young, inactive; old (60–80 years), active; or old, inactive. To assess physical activity status, participants completed a Paffenbarger Physical Activity Questionnaire and a modified Balke submaximal treadmill test. After grouping and screening, participants were given a standard mixed diet to consume 24 hours prior to arriving at the laboratory. Participants were instructed to consume all food by 10 pm the night prior to blood sampling (8-hour fast). Following 30 minutes of seated rest in a quiet room, venous blood samples were collected. Lipopolysaccharide-stimulated inflammatory cytokine production and plasma high-sensitivity C-reactive protein (hsCRP) were determined by enzyme-linked immunosorbent assay, and TLR4 expression was determined by flow cytometry. Results. Lipopolysaccharide-stimulated interleukin-6, interleukin-1β, and tumor necrosis factor-α production, TLR4 expression, and hsCRP were significantly lower in active compared to inactive participants ( p <.05). Also, older participants had significantly higher hsCRP than young participants had ( p <.05). Conclusions. The findings of the present study support previous reports which infer that acute exercise or a physically active lifestyle may possess anti-inflammatory properties. Also this study, along with previous work from our laboratory, suggests that TLR4 may play a role in regulating the link between inflammatory cytokine production and a physically active lifestyle. The Gerontological Society of America « Previous | Next Article » Table of Contents This Article J Gerontol A Biol Sci Med Sci (2006) 61 (4): 388-393. » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Journal of Gerontology: Medical Sciences Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by McFarlin, B. K. Articles by Coen, P. M. Search for related content PubMed PubMed citation Articles by McFarlin, B. K. Articles by Flynn, M. G. Articles by Campbell, W. W. Articles by Craig, B. A. Articles by Robinson, J. P. Articles by Stewart, L. K. Articles by Timmerman, K. L. Articles by Coen, P. M. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 70 (11) Alert me to new issues The Journal About the journal Translational Articles Free Editors’ Choice Articles Impact Factor Articles The Journals of Gerontology, Series A Supplements Special Issues Rights & permissions We are mobile – find out more Journal Career Network Published on behalf of The Gerontological Society of America Impact Factor: 5.416 5-Yr impact factor: 5.406 Editorial Boards The Journals of Gerontology, Series A: Biological Sciences Rafael de Cabo, PhD, Editor View full editorial board The Journals of Gerontology, Series A: Medical Sciences Stephen B. Kritchevsky, PhD View full editorial board For the Media GSA Press Room For Authors Instructions to authors Services for authors Submit Now: Biological Sciences Submit Now: Medical Sciences Self-Archiving Policy Online Submission Open access options for authors - visit Oxford Open WhsSvhnOkaAwYG81FJCYgwG7z1LnIP2F true Looking for your next opportunity? Looking for jobs... jQuery_1_11 = jQuery.noConflict(true); Corporate Services What we offer Advertising sales Reprints Supplements Classified Advertising Sales Alerting Services Email table of contents CiteTrack XML RSS feed var taxonomies = ("MED00280", "SCI00960"); Most Most Read A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity Frailty in Older Adults: Evidence for a Phenotype Nutrition, Physical Activity, and Quality of Life in Older Adults: Summary The Top 10 Hot Topics in Aging » View all Most Read articles Most Cited Frailty in Older Adults: Evidence for a Phenotype Lower Extremity Function and Subsequent Disability: Consistency Across Studies, Predictive Models, and Value of Gait Speed Alone Compared With the Short Physical Performance Battery The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study Muscle Mass, Muscle Strength, and Muscle Fat Infiltration as Predictors of Incident Mobility Limitations in Well-Functioning Older Persons Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1758-535X - Print ISSN 1079-5006 Copyright © 2015 The Gerontological Society of America Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-16"); pageTracker._setDomainName(".oxfordjournals.org"); pageTracker._trackPageview(); } catch(err) {} http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences Oxford University Press

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Publisher
Oxford University Press
Copyright
Copyright © 2015 The Gerontological Society of America
ISSN
1079-5006
eISSN
1758-535X
D.O.I.
biomedgerontology;61/4/388
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Abstract

Background. Chronic inflammation has been implicated in the development of cardiovascular disease, diabetes mellitus, cachexia, and osteoporosis. Regular physical activity has been purported to possess “anti-inflammatory” properties which may limit chronic inflammation. Recently, we hypothesized that toll-like receptor 4 (TLR4) may play a role in activity-induced modulation of inflammation. Therefore, the purpose of this study was to determine the association between age, physical activity status, biomarkers of inflammation, and TLR4. Methods. Male and female participants ( n = 84) were recruited to fill one of the following groups: young (18–30 years), active; young, inactive; old (60–80 years), active; or old, inactive. To assess physical activity status, participants completed a Paffenbarger Physical Activity Questionnaire and a modified Balke submaximal treadmill test. After grouping and screening, participants were given a standard mixed diet to consume 24 hours prior to arriving at the laboratory. Participants were instructed to consume all food by 10 pm the night prior to blood sampling (8-hour fast). Following 30 minutes of seated rest in a quiet room, venous blood samples were collected. Lipopolysaccharide-stimulated inflammatory cytokine production and plasma high-sensitivity C-reactive protein (hsCRP) were determined by enzyme-linked immunosorbent assay, and TLR4 expression was determined by flow cytometry. Results. Lipopolysaccharide-stimulated interleukin-6, interleukin-1β, and tumor necrosis factor-α production, TLR4 expression, and hsCRP were significantly lower in active compared to inactive participants ( p <.05). Also, older participants had significantly higher hsCRP than young participants had ( p <.05). Conclusions. The findings of the present study support previous reports which infer that acute exercise or a physically active lifestyle may possess anti-inflammatory properties. Also this study, along with previous work from our laboratory, suggests that TLR4 may play a role in regulating the link between inflammatory cytokine production and a physically active lifestyle. The Gerontological Society of America « Previous | Next Article » Table of Contents This Article J Gerontol A Biol Sci Med Sci (2006) 61 (4): 388-393. » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Journal of Gerontology: Medical Sciences Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by McFarlin, B. K. Articles by Coen, P. M. Search for related content PubMed PubMed citation Articles by McFarlin, B. K. Articles by Flynn, M. G. Articles by Campbell, W. W. Articles by Craig, B. A. Articles by Robinson, J. P. Articles by Stewart, L. K. Articles by Timmerman, K. L. Articles by Coen, P. M. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 70 (11) Alert me to new issues The Journal About the journal Translational Articles Free Editors’ Choice Articles Impact Factor Articles The Journals of Gerontology, Series A Supplements Special Issues Rights & permissions We are mobile – find out more Journal Career Network Published on behalf of The Gerontological Society of America Impact Factor: 5.416 5-Yr impact factor: 5.406 Editorial Boards The Journals of Gerontology, Series A: Biological Sciences Rafael de Cabo, PhD, Editor View full editorial board The Journals of Gerontology, Series A: Medical Sciences Stephen B. Kritchevsky, PhD View full editorial board For the Media GSA Press Room For Authors Instructions to authors Services for authors Submit Now: Biological Sciences Submit Now: Medical Sciences Self-Archiving Policy Online Submission Open access options for authors - visit Oxford Open WhsSvhnOkaAwYG81FJCYgwG7z1LnIP2F true Looking for your next opportunity? Looking for jobs... jQuery_1_11 = jQuery.noConflict(true); Corporate Services What we offer Advertising sales Reprints Supplements Classified Advertising Sales Alerting Services Email table of contents CiteTrack XML RSS feed var taxonomies = ("MED00280", "SCI00960"); Most Most Read A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity Frailty in Older Adults: Evidence for a Phenotype Nutrition, Physical Activity, and Quality of Life in Older Adults: Summary The Top 10 Hot Topics in Aging » View all Most Read articles Most Cited Frailty in Older Adults: Evidence for a Phenotype Lower Extremity Function and Subsequent Disability: Consistency Across Studies, Predictive Models, and Value of Gait Speed Alone Compared With the Short Physical Performance Battery The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study Muscle Mass, Muscle Strength, and Muscle Fat Infiltration as Predictors of Incident Mobility Limitations in Well-Functioning Older Persons Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1758-535X - Print ISSN 1079-5006 Copyright © 2015 The Gerontological Society of America Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-16"); pageTracker._setDomainName(".oxfordjournals.org"); pageTracker._trackPageview(); } catch(err) {}

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The Journals of Gerontology Series A: Biomedical Sciences and Medical SciencesOxford University Press

Published: Apr 1, 2006

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