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Oral Irritant Properties of Piperine and Nicotine: Psychophysical Evidence for Asymmetrical Desensitization Effects

Oral Irritant Properties of Piperine and Nicotine: Psychophysical Evidence for Asymmetrical... Using a bipolar rating scale, human subjects rated the intensity of irritation sensation evoked by repeated application of piperine (75 p.p.m.) or nicotine (0.12%) to one side of the dorsal surface of the tongue. The intensity of irritation elicited by repeated application of piperine significantly increased, while irritation elicited by repeated nicotine significantly decreased. We additionally tested if nicotine or piperine desensitized the tongue. After either piperine or nicotine was repeatedly applied to one side of the tongue, a 5 or 10 min rest period ensued, followed by re-application of piperine or nicotine to both sides of the tongue. Subjects were asked to choose which side of the tongue gave rise to a stronger irritation in a two-alternative forced choice (2-AFC) paradigm. In addition, they gave separate ratings of the intensity of irritation on the two sides of the tongue. When piperine was applied bilaterally after unilateral pretreatment with piperine and a 10 min rest period, subjects consistently chose the non-pretreated side to yield stronger irritation and assigned significantly higher ratings to that side, indicative of piperine self-desensitization. A similar self-desensitization effect was found when bilateral application of nicotine followed unilateral treatment with nicotine and a 5 min rest period. Unilateral treatment with piperine also reduced nicotine-evoked irritation on the pretreated side (cross-desensitization), but treatment with nicotine did not affect piperine-evoked irritation. This asymmetrical cross-desensitization pattern is similar to that observed between capsaicin and nicotine and constitutes an additional similarity between piperine and capsaicin. Oxford University Press « Previous | Next Article » Table of Contents This Article Chem. Senses (1999) 24 (4): 405-413. doi: 10.1093/chemse/24.4.405 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Article Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Disclaimer Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Dessirier, J. M. Articles by O’Mahony, M. Search for related content PubMed PubMed citation Articles by Dessirier, J. M. Articles by Nguyen, N. Articles by Sieffermann, J. M. Articles by Carstens, E. Articles by O’Mahony, M. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 40 (9) Alert me to new issues The Journal About this journal Publishers' Books for Review Rights & Permissions Dispatch date of the next issue This journal is a member of the Committee on Publication Ethics (COPE) We are mobile – find out more Journals Career Network The official journal of AACSS ACHEMS ECRO JASTS Impact factor: 3.157 5-Yr impact factor: 3.199 Editor-in-Chief: Wolfgang Meyerhof View full editorial board For Authors Instructions to authors Online submission Self archiving policy Open access options for authors - visit Oxford Open This journal enables compliance with the NIH Public Access Policy Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("SCI01180"); Most Most Read Distortion of Olfactory Perception: Diagnosis and Treatment Effects of Fragrance on Emotions: Moods and Physiology What the Tongue Tells the Brain about Taste Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases The Discovery of Umami » View all Most Read articles Most Cited 'Sniffin' Sticks': Olfactory Performance Assessed by the Combined Testing of Odour Identification, Odor Discrimination and Olfactory Threshold Evaluating the 'Labeled Magnitude Scale' for Measuring Sensations of Taste and Smell The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors Parallel-distributed Processing in Olfactory Cortex: New Insights from Morphological and Physiological Analysis of Neuronal Circuitry A metric for the breadth of tuning of gustatory neurons » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. 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Oral Irritant Properties of Piperine and Nicotine: Psychophysical Evidence for Asymmetrical Desensitization Effects

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Publisher
Oxford University Press
Copyright
Copyright © 2015 Oxford University Press
ISSN
0379-864X
eISSN
1464-3553
DOI
10.1093/chemse/24.4.405
Publisher site
See Article on Publisher Site

Abstract

Using a bipolar rating scale, human subjects rated the intensity of irritation sensation evoked by repeated application of piperine (75 p.p.m.) or nicotine (0.12%) to one side of the dorsal surface of the tongue. The intensity of irritation elicited by repeated application of piperine significantly increased, while irritation elicited by repeated nicotine significantly decreased. We additionally tested if nicotine or piperine desensitized the tongue. After either piperine or nicotine was repeatedly applied to one side of the tongue, a 5 or 10 min rest period ensued, followed by re-application of piperine or nicotine to both sides of the tongue. Subjects were asked to choose which side of the tongue gave rise to a stronger irritation in a two-alternative forced choice (2-AFC) paradigm. In addition, they gave separate ratings of the intensity of irritation on the two sides of the tongue. When piperine was applied bilaterally after unilateral pretreatment with piperine and a 10 min rest period, subjects consistently chose the non-pretreated side to yield stronger irritation and assigned significantly higher ratings to that side, indicative of piperine self-desensitization. A similar self-desensitization effect was found when bilateral application of nicotine followed unilateral treatment with nicotine and a 5 min rest period. Unilateral treatment with piperine also reduced nicotine-evoked irritation on the pretreated side (cross-desensitization), but treatment with nicotine did not affect piperine-evoked irritation. This asymmetrical cross-desensitization pattern is similar to that observed between capsaicin and nicotine and constitutes an additional similarity between piperine and capsaicin. Oxford University Press « Previous | Next Article » Table of Contents This Article Chem. Senses (1999) 24 (4): 405-413. doi: 10.1093/chemse/24.4.405 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Article Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Disclaimer Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Dessirier, J. M. Articles by O’Mahony, M. Search for related content PubMed PubMed citation Articles by Dessirier, J. M. Articles by Nguyen, N. Articles by Sieffermann, J. M. Articles by Carstens, E. Articles by O’Mahony, M. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 40 (9) Alert me to new issues The Journal About this journal Publishers' Books for Review Rights & Permissions Dispatch date of the next issue This journal is a member of the Committee on Publication Ethics (COPE) We are mobile – find out more Journals Career Network The official journal of AACSS ACHEMS ECRO JASTS Impact factor: 3.157 5-Yr impact factor: 3.199 Editor-in-Chief: Wolfgang Meyerhof View full editorial board For Authors Instructions to authors Online submission Self archiving policy Open access options for authors - visit Oxford Open This journal enables compliance with the NIH Public Access Policy Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("SCI01180"); Most Most Read Distortion of Olfactory Perception: Diagnosis and Treatment Effects of Fragrance on Emotions: Moods and Physiology What the Tongue Tells the Brain about Taste Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases The Discovery of Umami » View all Most Read articles Most Cited 'Sniffin' Sticks': Olfactory Performance Assessed by the Combined Testing of Odour Identification, Odor Discrimination and Olfactory Threshold Evaluating the 'Labeled Magnitude Scale' for Measuring Sensations of Taste and Smell The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors Parallel-distributed Processing in Olfactory Cortex: New Insights from Morphological and Physiological Analysis of Neuronal Circuitry A metric for the breadth of tuning of gustatory neurons » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1464-3553 - Print ISSN 0379-864X Copyright © 2015 Oxford University Press Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? 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Journal

Chemical SensesOxford University Press

Published: Aug 1, 1999

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