Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1989)
FK506. How much potential
N. Horning, J. Lynch, S. Sundaresan, G. Patterson, E. Trulock (1998)
Tacrolimus therapy for persistent or recurrent acute rejection after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 8
R. Nakanishi, K. Yasumoto (2005)
Efficacy of Multiglycosidorum tripterygii for rat tracheal allografts.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 24 3
Marshall Hertz, Jose Jessurun, M. King, S. Savik, J. Murray (1993)
Reproduction of the obliterative bronchiolitis lesion after heterotopic transplantation of mouse airways.The American journal of pathology, 142 6
M. Hashimoto, R. Nakanishi, H. Muranaka, M. Umesue, R. Eifuku, K. Yasumoto (2000)
Short-course immunosuppression using FK506 for rat tracheal allografts.The Journal of cardiovascular surgery, 41 3
R. Nakanishi, K. Yasumoto (1995)
Minimal dose of cyclosporin A for tracheal allografts.The Annals of thoracic surgery, 60 3
A. Thomson (1989)
How much potential
(1999)
Inhibitory effect of Multiglycosidorum tripterygii, a new immunosuppressant, suppresses coronary arteriosclerosis after heart transplantation
J. Hosenpud, L. Bennett, B. Keck, M. Boucek, R. Novick (2001)
The Registry of the International Society for Heart and Lung Transplantation: eighteenth Official Report-2001.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 20 8
J. Kutney, G. Hewitt, Gin Lee, K. Piotrowska, M. Roberts, S. Rettig (1992)
Studies with tissue cultures of the Chinese herbal plant, Tripterygiumwilfordii. Isolation of metabolites of interest in rheumatoid arthritis, immunosuppression, and male contraceptive activityCanadian Journal of Chemistry, 70
S. Miyagawa, S. Stepkowski, B. Kahan (1991)
Mechanism of unresponsiveness in rats induced by a short course of FK 506 or CyA.Transplantation proceedings, 23 1 Pt 1
M. Hashimoto, R. Nakanishi, M. Umesue, H. Muranaka, M. Hachida, K. Yasumoto (2001)
Feasibility of cryopreserved tracheal xenotransplants with the use of short-course immunosuppression.The Journal of thoracic and cardiovascular surgery, 121 2
A. Thomson (1989)
FK-506--how much potential?Immunology today, 10 1
J. Kutney, G. Hewitt, Gin Lee, K. Piotrowska, M. Roberts, S. Rettig (1993)
Studies with Tissue Cultures of the Chinese Herbal Plant, Tripterygium wilfordii. Isolation of Metabolites of Interest in Rheumatoid Arthritis, Immunosuppression, and Male Contraceptive ActivityChemInform, 24
H. Tazelaar, J. Prop, P. Nieuwenhuis, M. Billingham, C. Wildevuur (1986)
AIRWAY PATHOLOGY IN THE TRANSPLANTED RAT LUNGTransplantation, 45
(1991)
Mechanism of unresponsiveness in rat induced by a short course of FK506 or CyA
M. Hachida, X. Zhang, H. Lu, H. Hoshi, H. Koyanagi (1999)
Multiglycosidorum tripterygii, a new immunosuppressant, supresses coronary arteriosclerosis after heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 18 3
R. Nakanishi, T. Shirakusa, T. Hanagiri (1994)
Early histopathologic features of tracheal allotransplant rejection: a study in nonimmunosuppressed dogs.Transplantation proceedings, 26 6
I. Neuringer, R. Mannon, T. Coffman, M. Parsons, K. Burns, J. Yankaskas, R. Aris (1998)
Immune cells in a mouse airway model of obliterative bronchiolitis.American journal of respiratory cell and molecular biology, 19 3
R. Nakanishi, K. Yasumoto, Takayuki Shirakusa (1995)
Short-course immunosuppression after tracheal allotransplantation in dogs.The Journal of thoracic and cardiovascular surgery, 109 5
T. Hirai, T. Waddell, K. Decampos, C. Compeau, H. Wada, S. Hitomi, G. Patterson, Arthur Slutsky (1994)
A short course of FK506 can induce limited donor-specific graft acceptance.The Annals of thoracic surgery, 58 2
Xia Li, M. Weir (1990)
RADIX Tripterygium Wilfordii—A CHINESE HERBAL MEDICINE WITH POTENT IMMUNOSUPPRESSIVE PROPERTIESTransplantation, 50
W. Gu, Randal Chen, Sydney Brandwein, James Mcalpine, Neal Burres (1995)
Isolation, purification, and characterization of immunosuppressive compounds from tripterygium: triptolide and tripdiolide.International journal of immunopharmacology, 17 5
M. Hachida, X. Zhang, H. Lu, H. Hoshi, H. Koyanagi (1998)
Inhibitory effect of Multiglycosidorum tripterygii on coronary arteriosclerosis after heart transplantation.Transplantation, 65 11
Objective: Several other immunosuppressive agents still need to be found for rejection as alternatives to Tacrolimus in lung transplantation. We tried to elucidate the treatment effect of Multiglycosidorum tripterygii on tracheal allografts in comparison to that of Tacrolimus. Methods: Treatment effect of agents on tracheal allografts, undergoing incomplete immunosuppression for 12 weeks after transplantation, was investigated using a heterotopic rat tracheal transplantation model. Treatments with Tacrolimus (1.0 or 1.5mg/kg per day), Multiglycosidorum tripterygii (150 or 225mg/kg per day) and a combination of Tacrolimus (1.0mg/kg per day) and Multiglycosidorum tripterygii (150mg/kg per day) were applied as a therapy for allografts. Four weeks after administering this therapy, the effect of each treatment was investigated by the morphologic assessment of transplants. Results: Treatment group with high doses of Multiglycosidorum tripterygii demonstrated a significantly better graft patency and lower cartilage dislocation than that without any treatment and tended to show better morphological findings than the other treatment groups, in addition to being safe. Some of allografts with high doses of Tacrolimus or Multiglycosidorum tripterygii therapy had a viable epithelium and viable tracheal glands in part, whereas the allografts with other treatments showed almost a completely denuded epithelium. High doses of Multiglycosidorum tripterygii therapy demonstrated less infiltration of mononuclear cells into the allografts, whereas other therapies showed a higher infiltration of such cells. Conclusions: We conclude that high doses of Multiglycosidorum tripterygii may be a useful alternative to Tacrolimus as an immunosuppressant for rat tracheal allografts.
European Journal of Cardio-Thoracic Surgery – Oxford University Press
Published: Oct 1, 2005
Keywords: Allograft Animal model Lung transplantation Rejection Trachea
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.