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Mortality and neurodevelopmental outcome at 1 year of age comparing hybrid and Norwood procedures

Mortality and neurodevelopmental outcome at 1 year of age comparing hybrid and Norwood procedures OBJECTIVESNeonates with hypoplastic left heart syndrome (HLHS) are at risk of high mortality and neurodevelopmental morbidity. As an alternative to Norwood-type stage I palliation, the hybrid procedure has been developed. It consists of bilateral pulmonary artery banding, catheter-based stenting of the arterial duct and balloon atrioseptostomy and delays open-heart surgery. Thus, it may be associated with a better outcome. The aim of this study was to determine the mortality and neurodevelopmental outcome in patients with HLHS and other univentricular heart (UVH) defects treated with hybrid or Norwood procedures.METHODSThirty-one children (18 males) with HLHS and other UVH defects undergoing Norwood or hybrid procedure between 2004 and 2008 were consecutively enrolled. Mortality and neurodevelopmental outcome at 1 year of age were determined.RESULTSOne-year mortality was 36 (31 in the hybrid vs. 39 in the Norwood group, P0.71). Predictors of mortality were lower birth weight (P0.02), older age at first procedure (P0.02) and smaller size of ascending aorta (P0.05). Overall, median psychomotor development index (PDI) and mental development index (MDI) of the Bayley Scales of Infant Development II were lower than the norm of 100 [PDI 57 (4999), P<0.001; MDI 91 (65109), P0.002]. No effect of surgical treatment on neurodevelopmental outcome was found. Predictors of impaired motor outcome were length of hospital stay (LOHS) (P0.01), lower body weight at second procedure (P0.004) and female sex (P0.01). Predictors of impaired cognitive outcome were longer mechanical ventilation time (P0.03), intensive care unit stay (P0.04) and LOHS (P<0.001), respectively.CONCLUSIONSMortality at 1 year of age is comparable between patients undergoing hybrid and Norwood procedures. Early neurodevelopmental outcome is significantly impaired in patients with both HLHS and other UVH defects. Multicentre randomized studies are needed to determine the long-term neurodevelopmental outcome of children treated with the hybrid procedure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Cardio-Thoracic Surgery Oxford University Press

Mortality and neurodevelopmental outcome at 1 year of age comparing hybrid and Norwood procedures

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References (29)

Publisher
Oxford University Press
Copyright
The Author 2012. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
Subject
CONGENITAL
ISSN
1010-7940
eISSN
1873-734X
DOI
10.1093/ejcts/ezr286
pmid
22290896
Publisher site
See Article on Publisher Site

Abstract

OBJECTIVESNeonates with hypoplastic left heart syndrome (HLHS) are at risk of high mortality and neurodevelopmental morbidity. As an alternative to Norwood-type stage I palliation, the hybrid procedure has been developed. It consists of bilateral pulmonary artery banding, catheter-based stenting of the arterial duct and balloon atrioseptostomy and delays open-heart surgery. Thus, it may be associated with a better outcome. The aim of this study was to determine the mortality and neurodevelopmental outcome in patients with HLHS and other univentricular heart (UVH) defects treated with hybrid or Norwood procedures.METHODSThirty-one children (18 males) with HLHS and other UVH defects undergoing Norwood or hybrid procedure between 2004 and 2008 were consecutively enrolled. Mortality and neurodevelopmental outcome at 1 year of age were determined.RESULTSOne-year mortality was 36 (31 in the hybrid vs. 39 in the Norwood group, P0.71). Predictors of mortality were lower birth weight (P0.02), older age at first procedure (P0.02) and smaller size of ascending aorta (P0.05). Overall, median psychomotor development index (PDI) and mental development index (MDI) of the Bayley Scales of Infant Development II were lower than the norm of 100 [PDI 57 (4999), P<0.001; MDI 91 (65109), P0.002]. No effect of surgical treatment on neurodevelopmental outcome was found. Predictors of impaired motor outcome were length of hospital stay (LOHS) (P0.01), lower body weight at second procedure (P0.004) and female sex (P0.01). Predictors of impaired cognitive outcome were longer mechanical ventilation time (P0.03), intensive care unit stay (P0.04) and LOHS (P<0.001), respectively.CONCLUSIONSMortality at 1 year of age is comparable between patients undergoing hybrid and Norwood procedures. Early neurodevelopmental outcome is significantly impaired in patients with both HLHS and other UVH defects. Multicentre randomized studies are needed to determine the long-term neurodevelopmental outcome of children treated with the hybrid procedure.

Journal

European Journal of Cardio-Thoracic Surgery – Oxford University Press

Published: Jul 18, 2012

Keywords: Congenital heart defects Hypoplastic left heart syndrome Norwood operation Cardiopulmonary bypass Neurocognitive deficits Hybrid procedure

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