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The numerous conditions that clinicians group under the term ‘age-related macular degeneration’ (AMD) are collectively the most common cause of severe visual loss in the developed world. Moreover, the number of people affected by these diseases is expected to nearly double in the next 25 years. A growing body of data suggests that a large fraction of AMD is caused by genetic factors. As a result, numerous investigators have sought genes that contribute to this disorder. At least six genes have now been identified that cause heritable macular disease, but none of these seem to cause even a moderate fraction of AMD. Affected pedigree member studies suggest that some regions of the genome do harbor AMD predisposing genes, but none have yet been identified by this approach. Studies of human donor tissue have yielded important new insights into pathways associated with AMD. These studies, when combined with the power of genetic approaches, are likely to ultimately reveal a set of genes responsible for a sizeable fraction of AMD. Received July 17, 2001; Accepted July 24, 2001. Edwin M. Stone 1 , + , Val C. Sheffield 2 , 3 and Gregory S. Hageman 1 1 Department of Ophthalmology and 2 Department of Pediatrics, The University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA and 3 The Howard Hughes Medical Institute, Iowa City, IA 52242, USA « Previous | Next Article » Table of Contents This Article Hum. Mol. Genet. (2001) 10 (20): 2285-2292. doi: 10.1093/hmg/10.20.2285 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Review Review Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Stone, E. M. Articles by Hageman, G. S. Search for related content PubMed PubMed citation Articles by Stone, E. M. Articles by Sheffield, V. C. Articles by Hageman, G. S. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? 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Human Molecular Genetics – Oxford University Press
Published: Oct 1, 2001
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