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Q J Med 1998; 91:795798 Mini-review QJM The management of carcinoid tumours S. HALFORD and J. WAXMAN From the Department of Oncology, Imperial College, London, UK Introduction The term `karzinoide' was originally used by Obendorfer in 1907 to describe a carcinoma-like lesion without malignant qualities. These tumours are uncommon, and attract the interest of clinicians because of the spectacular symptoms that they cause. These symptoms are so striking as to make clinical diagnosis obvious, but because of their range, unfortunately result in patients being cared for by many different medical and surgical specialists. Carcinoid tumours, even when there is metastatic spread, are generally thought to have a good prognosis and as a result, patients with this condition are managed symptomatically. However, Godwin et al. assessed survival in 2837 patients with carcinoids, and in patients with liver metastases and raised urinary 5HIAA levels he reported a five-year survival of 1838% and a median survival of 23 months.1 These figures suggest that carcinoid tumour is a rather more aggressive disease than is generally appreciated. In this article we review recent clinical developments, make a case for specialist care, and promote the view that chemotherapy given with the aim of reducing
QJM: An International Journal of Medicine – Oxford University Press
Published: Dec 1, 1998
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