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Immunology of type 1 diabetes

Immunology of type 1 diabetes Q J Med 2005; 98:547–556 Advance Access publication 13 June 2005 doi:10.1093/qjmed/hci088 Review 1 2 3 P. NARENDRAN , E. ESTELLA and S. FOURLANOS From Clinical Science at North Bristol, University of Bristol, Southmead Hospital, Bristol, UK, 2 3 St Vincent’s Institute, Fitzroy, Victoria, Australia, and Autoimmunity and Transplant Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia Introduction The incidence of type 1 diabetes in the UK is 20 per volume, weigh about 1 g, and contain about 1 mg 100 000 and increasing, particularly in the under- of insulin. Histological analysis of the pancreas 5-years age group. It comes with the burden of from patients with type 1 diabetes shows immuno- daily insulin injection and blood testing, as well logical activity not present in a healthy or a type 2 as both short- and long-term complications, and diabetic pancreas. This activity is limited to insulin- this can include premature death. The standardized containing islets, includes infiltration by activated mortality ratio for type 1 diabetes has been lymphocytes, antibodies and components of the estimated as 4-fold for females and 2.7-fold for complement system. These histological findings are males in the UK. Even with tight http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png QJM: An International Journal of Medicine Oxford University Press

Immunology of type 1 diabetes

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References (93)

Publisher
Oxford University Press
Copyright
© The Author 2005. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
ISSN
1460-2725
eISSN
1460-2393
DOI
10.1093/qjmed/hci088
pmid
15955793
Publisher site
See Article on Publisher Site

Abstract

Q J Med 2005; 98:547–556 Advance Access publication 13 June 2005 doi:10.1093/qjmed/hci088 Review 1 2 3 P. NARENDRAN , E. ESTELLA and S. FOURLANOS From Clinical Science at North Bristol, University of Bristol, Southmead Hospital, Bristol, UK, 2 3 St Vincent’s Institute, Fitzroy, Victoria, Australia, and Autoimmunity and Transplant Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia Introduction The incidence of type 1 diabetes in the UK is 20 per volume, weigh about 1 g, and contain about 1 mg 100 000 and increasing, particularly in the under- of insulin. Histological analysis of the pancreas 5-years age group. It comes with the burden of from patients with type 1 diabetes shows immuno- daily insulin injection and blood testing, as well logical activity not present in a healthy or a type 2 as both short- and long-term complications, and diabetic pancreas. This activity is limited to insulin- this can include premature death. The standardized containing islets, includes infiltration by activated mortality ratio for type 1 diabetes has been lymphocytes, antibodies and components of the estimated as 4-fold for females and 2.7-fold for complement system. These histological findings are males in the UK. Even with tight

Journal

QJM: An International Journal of Medicine – Oxford University Press

Published: Aug 13, 2005

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