NUTRITION CLASSICS PROCEEDINGS OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA OCTOBER 1978 VOLUME 75 NUMBER 10 PP 5057-5061 Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts MICHAEL KLAGSBRUN Editorâs Note: The fact that human milk contains mitogens that stimulate cell proliferation was an exciting new discovery. It may explain the trophic effects of human milk on the immature gastrointestinal tract of infants. Human milk contains certain factors that help the human infant compensate for the immaturity of some of its tissues. For example, human milk has high levels of secretory IgA. The IgA and other antibodies help confer passive immunity on the infant. In this report, we demonstrate that human milk contains a polypeptide growth factor capable of inducing DNA synthesis and cell division in cultured cells. Unfractionated human milk has a specific activity 50 to 100 times greater than unfractionated serum. Some of the biological and biochemical properties of the milk-derived growth factor are described. MATERIALS AND METHODS Cell Culture. Mouse BALB/c 3T3 embryo fibroblasts (clone A31) were obtained from C.D. Scher (Harvard Medical School, Boston, MA). Human foreskin fibroblasts were prepared by trypsinization of foreskin and subsequent passage
Nutrition Reviews – Oxford University Press
Published: Jan 1, 1988
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