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Letters to the Editor 1297 of mild, early inflammatory arthritis. Arthritis Rheum toid arthritis ( RA) [ 2 ]. Smith and colleagues refer to 1999;42:2184–8. their extensive previous work on the beneficial effects of 5. Sternberg EM, Hill JM, Chrousos GP et al. Inflammatory medi- intravenous MP pulses on clinical features and the ator-induced hypothalamic–pituitary–adrenal axis activation is molecular and cellular processes in RA. We believe two defective in streptococcal cell wall arthritis susceptible Lewis rats. Proc Natl Acad Sci USA 1989;86:2374–8. further issues are worth considering in the delineation 6. Masi AT, Bijlsma JWJ, Chikanza IC, Pitzalis C, Cutolo M. of the role of MP pulses and other glucocorticoid Neuroendocrine, immunologic, and microvascular systems regimens in future studies in this disease. interactions in rheumatoid arthritis: physiopathogenetic and While most investigators have used relatively high therapeutic perspectives. Semin Arthritis Rheum 1999;29:65–81. 7. Wickens T, De Rijk R. Glucocorticoids and immune function: doses of MP, this may not be universally indicated. unknown dimensions and new frontiers. Immunol Today Doses as low as 120 mg MP, given i.m., were reported 1997;18:418–23. to be of benefit as bridge therapy in RA [ 3 ]. In a recent 8. Jefferies WM, Cleveland MD.
Rheumatology – Oxford University Press
Published: Nov 1, 2000
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