Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Paganga, C. Rice-evans (1997)
The identification of flavonoids as glycosides in human plasmaFEBS Letters, 401
S. Kono, K. Shinchi, N. Ikeda, F. Yanai, K. Imanishi (1991)
Physical activity, dietary habits and adenomatous polyps of the sigmoid colon: a study of self-defense officials in Japan.Journal of clinical epidemiology, 44 11
R. Anderson, Chanchala Amarasinghe, L. Fisher, Wai Mak, J. Packer (2000)
Reduction in free-radical-induced DNA strand breaks and base damage through fast chemical repair by flavonoidsFree Radical Research, 33
W. Bors, M. Saran (1987)
Radical scavenging by flavonoid antioxidants.Free radical research communications, 2 4-6
A. Rahman, Shahabuddin, S. Hadi, J. Parish (1990)
Complexes involving quercetin, DNA and Cu(II).Carcinogenesis, 11 11
R. Anderson, L. Fisher, T. Harris (2001)
The ‘pivotal antioxidant’ hypothesis for the role of flavonoids in their reduction of HO· radical-induced damage on DNARedox Report, 6
Cerutti Pa (1989)
Mechanisms of action of oxidant carcinogens.Cancer Detection and Prevention, 14
P. Jocelyn (1972)
Biochemistry of the SH group : the occurrence, chemical properties, metabolism and biological function of thiols and disulphides
M. Ahmed, V. Ramesh, V. Nagaraja, J. Parish, S. Hadi (1994)
Mode of binding of quercetin to DNA.Mutagenesis, 9 3
C. Rice-evans, N. Miller, G. Paganga (1996)
Structure-antioxidant activity relationships of flavonoids and phenolic acids.Free radical biology & medicine, 20 7
Z. Wang, M. Das, D. Bickers, H. Mukhtar (1988)
Interaction of epicatechins derived from green tea with rat hepatic cytochrome P-450.Drug metabolism and disposition: the biological fate of chemicals, 16 1
S. Husain, J. Cillard, P. Cillard (1987)
Hydroxyl radical scavenging activity of flavonoidsPhytochemistry, 26
M. Namiki (1990)
Antioxidants/antimutagens in food.Critical reviews in food science and nutrition, 29 4
Riccardo Solimani (1996)
Quercetin and DNA in solution: analysis of the dynamics of their interaction with a linear dichroism study.International journal of biological macromolecules, 18 4
N. Williams, J. Yandell (1982)
Outer-sphere electron-transfer reactions of ascorbate anionsAustralian Journal of Chemistry, 35
R. Olinski, T. Zastawny, J. Budzbon, J. Skokowski, Wojtek Zegarski, M. Dizdaroglu (1992)
DNA base modifications in chromatin of human cancerous tissuesFEBS Letters, 309
G. Jones, P. O'Neill (1990)
The kinetics of radiation-induced strand breakage in polynucleotides in the presence of oxygen: a time-resolved light-scattering study.International journal of radiation biology, 57 6
S. Katiyar, H. Mukhtar (1996)
Tea in chemoprevention of cancer.International journal of oncology, 8 2
O. Lux, D. Naidoo (1994)
Biological variation of ascorbic acid and α-tocopherol.Redox report : communications in free radical research, 1 1
L. Kohlmeier, K. Weterings, S. Steck, F. Kok (1997)
Tea and cancer prevention: an evaluation of the epidemiologic literature.Nutrition and cancer, 27 1
P. Pietta (2000)
Flavonoids as antioxidants.Journal of natural products, 63 7
M. Rice (2000)
Ascorbate regulation and its neuroprotective role in the brainTrends in Neurosciences, 23
S. Steenken, S. Jovanovic, M. Bietti, K. Bernhard (2000)
The trap depth (in DNA) of 8-oxo-7,8-dihydro-2'deoxyguanosine as derived from electron-transfer equilibria in aqueous solutionJournal of the American Chemical Society, 122
W. Blot, W. Chow, J. Mclaughlin (1996)
Tea and cancer: a review of the epidemiological evidence.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation, 5 6
I. Kato, S. Tominaga, A. Matsuura, Y. Yoshii, M. Shirai, Seibi Kobayashi (1990)
A Comparative Case‐Control Study of Colorectal Cancer and AdenomaJapanese Journal of Cancer Research : Gann, 81
Mao-jung Lee, Zhi-Yuan Wang, He Li, Laishun Chen, Yang Sun, Steve Gobbo, D. Balentine, Chung Yane (1995)
Analysis of plasma and urinary tea polyphenols in human subjects.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 4 4
Z. Wang, Wasiuddin Khan, D. Bickers, Hasan Mukhtar (1989)
Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols.Carcinogenesis, 10 2
Hans Verhagen, Henrik Poulsen, Steffen Loft, G. Poppel, Marianne Willems, Peter Bladeren (1995)
Reduction of oxidative DNA-damage in humans by brussels sprouts.Carcinogenesis, 16 4
J. Termini (2000)
Hydroperoxide-induced DNA damage and mutations.Mutation research, 450 1-2
S. Jovanovic, I. Janković, Ljubica Josimović (1992)
Electron-transfer reactions of alkylperoxy radicalsJournal of the American Chemical Society, 114
B. Ames, Lios Gold (1991)
Endogenous mutagens and the causes of aging and cancer.Mutation research, 250 1-2
H. Krokan, R. Standal, G. Slupphaug (1997)
DNA glycosylases in the base excision repair of DNA.The Biochemical journal, 325 ( Pt 1)
T. Prestera, P. Talalay (1995)
Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.Proceedings of the National Academy of Sciences of the United States of America, 92 19
S. Wallace (1998)
Enzymatic processing of radiation-induced free radical damage in DNA.Radiation research, 150 5 Suppl
D. Schulte‐Frohlinde, G. Behrens, A. Önal (1986)
Lifetime of peroxyl radicals of poly(U), poly(A) and single-and double-stranded DNA and the rate of their reaction with thiols.International journal of radiation biology and related studies in physics, chemistry, and medicine, 50 1
Sikandar Khan, S. Katiyar, R. Agarwal, H. Mukhtar (1992)
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.Cancer research, 52 14
J. Stubbe, J. Kozarich (1987)
Mechanisms of bleomycin-induced DNA degradationChemical Reviews, 87
P. Surdhar, D. Armstrong (1987)
Reduction potentials and exchange reactions of thiyl radicals and disulfide anion radicalsThe Journal of Physical Chemistry, 91
Ming-Hua Yang, K. Schaich (1996)
Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes.Free radical biology & medicine, 20 2
R. Anderson, W. Denny, Wenjie Li, J. Packer, M. Tercel, W. Wilson (1997)
Pulse Radiolysis Studies on the Fragmentation of Arylmethyl Quaternary Nitrogen Mustards by One-Electron Reduction in Aqueous SolutionJournal of Physical Chemistry A, 101
E. Cadenas, K. Davies (2000)
Mitochondrial free radical generation, oxidative stress, and aging.Free radical biology & medicine, 29 3-4
The catechins, (–)-epicatechin (EC), (–)-epigallocatechin (EGC), (–)-epicatechin gallate (ECG) and (–)-epigallocatechin gallate (EGCG) are believed to be active constituents of green tea accounting for the reported chemoprevention of certain cancers. The molecular mechanisms by which the measured low concentrations ( ca . micromolar) of catechins in humans can reduce the incidence of carcinogenesis is not clear. Using an in vitro plasmid DNA system and radiolytically generating reactive oxygen species (ROS) under constant scavenging conditions, we have shown that all four catechins, when present at low concentrations, ameliorate free radical damage sustained by DNA. A reduction in both prompt DNA single-strand breaks and residual damage to the DNA bases, detected by subsequent incubation with the DNA glycosylases formamidopyrimidine (FPG), endonuclease III (EndoIII) and 5′ AP endonuclease exonuclease III (ExoIII), was observed. EGCG was found to be the most active of the catechins, with effects seen at micromolar concentrations. Combined fast-reaction chemistry studies support a mechanism of electron transfer (or H-atom transfer) from catechins to ROS-induced radical sites on the DNA. These results support an antioxidant role for catechins in their direct interaction with DNA radicals. Key words D 0 , the radiation dose required on average to produce one DNA single-strand break E (1), one-electron reduction potiential at pH 7 versus normal hydrogen electrode EC, (−)-epicatechin ECG, (−)-epicatechin gallate EDTA, ethylenediaminetetraacetic acid EGC, (−)-epigallocatechin EGCG, (−)-epigallocatechin gallate EndoIII, endonuclease III Exoll, exonuclease III FPG, formidopyrimidine-DNA glycosylase G (ess), yield of endonuclease-indiced DNA single-stand breaks per absorbed dose (Gy) G (ssb), radiation chemical yield of single-strand breaks per absorbed dose (Gy) G (ssb′), reduction in G (ess) due to the presence of catechins Gy, absorbed radiation dose (J/kg) ROS, reactive oxygen specie TAE, Tris/acetic acid/EDTA buffer Tris, tris(hydroxy-methyl)aminomethane © Oxford University Press « Previous | Next Article » Table of Contents This Article Carcinogenesis (2001) 22 (8): 1189-1193. doi: 10.1093/carcin/22.8.1189 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Molecular Epidemiology and Cancer Prevention Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Anderson, R. F. Articles by Packer, J. E. Search for related content PubMed PubMed citation Articles by Anderson, R. F. Articles by Fisher, L. J. Articles by Hara, Y. Articles by Harris, T. Articles by Mak, W. B. Articles by Melton, L. D. Articles by Packer, J. E. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue October 2015 36 (10) Alert me to new issues The Journal About this journal Rights & Permissions Dispatch date of the next issue This journal is a member of the Committee on Publication Ethics (COPE) We are mobile – find out more Journals Career Network Impact factor: 5.334 5-Yr impact factor: 5.698 Editor-in-Chief Dr Curtis C Harris, USA View full editorial board For Authors Instructions to authors Online submission Submit Now! Self archiving policy Open access options for authors - visit Oxford Open This journal enables compliance with the NIH Public Access Policy Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("MED00710"); Most Most Read Apoptosis in cancer Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead Tumor progression and metastasis Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability » View all Most Read articles Most Cited Oxyradicals and DNA damage Sensing and repairing DNA double-strand breaks Functional role of estrogen metabolism in target cells: review and perspectives Apoptosis in cancer Nucleotide excision repair and human syndromes » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1460-2180 - Print ISSN 0143-3334 Copyright © 2015 Oxford University Press Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-16"); pageTracker._setDomainName(".oxfordjournals.org"); pageTracker._trackPageview(); } catch(err) {}
Carcinogenesis – Oxford University Press
Published: Aug 1, 2001
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.