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The catechins, (–)-epicatechin (EC), (–)-epigallocatechin (EGC), (–)-epicatechin gallate (ECG) and (–)-epigallocatechin gallate (EGCG) are believed to be active constituents of green tea accounting for the reported chemoprevention of certain cancers. The molecular mechanisms by which the measured low concentrations ( ca . micromolar) of catechins in humans can reduce the incidence of carcinogenesis is not clear. Using an in vitro plasmid DNA system and radiolytically generating reactive oxygen species (ROS) under constant scavenging conditions, we have shown that all four catechins, when present at low concentrations, ameliorate free radical damage sustained by DNA. A reduction in both prompt DNA single-strand breaks and residual damage to the DNA bases, detected by subsequent incubation with the DNA glycosylases formamidopyrimidine (FPG), endonuclease III (EndoIII) and 5′ AP endonuclease exonuclease III (ExoIII), was observed. EGCG was found to be the most active of the catechins, with effects seen at micromolar concentrations. Combined fast-reaction chemistry studies support a mechanism of electron transfer (or H-atom transfer) from catechins to ROS-induced radical sites on the DNA. These results support an antioxidant role for catechins in their direct interaction with DNA radicals. Key words D 0 , the radiation dose required on average to produce one DNA single-strand break E (1), one-electron reduction potiential at pH 7 versus normal hydrogen electrode EC, (−)-epicatechin ECG, (−)-epicatechin gallate EDTA, ethylenediaminetetraacetic acid EGC, (−)-epigallocatechin EGCG, (−)-epigallocatechin gallate EndoIII, endonuclease III Exoll, exonuclease III FPG, formidopyrimidine-DNA glycosylase G (ess), yield of endonuclease-indiced DNA single-stand breaks per absorbed dose (Gy) G (ssb), radiation chemical yield of single-strand breaks per absorbed dose (Gy) G (ssb′), reduction in G (ess) due to the presence of catechins Gy, absorbed radiation dose (J/kg) ROS, reactive oxygen specie TAE, Tris/acetic acid/EDTA buffer Tris, tris(hydroxy-methyl)aminomethane © Oxford University Press « Previous | Next Article » Table of Contents This Article Carcinogenesis (2001) 22 (8): 1189-1193. doi: 10.1093/carcin/22.8.1189 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Molecular Epidemiology and Cancer Prevention Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Anderson, R. 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Carcinogenesis – Oxford University Press
Published: Aug 1, 2001
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