Gentamicin and Tobramycin Binding to Human Serum In Vitro

Gentamicin and Tobramycin Binding to Human Serum In Vitro The binding of gentamicin and tobramycin to human serum was studied in vitro using equilibrium dialysis of pooled human serum supplemented to various concentrations of either drug. Only minimal and variable non-specific binding was noted for each drug: gentamicin, less than 15% and tobramycin, less than 30%. Conventional Scatchard analysis conducted over an array of drug concentrations failed to identify any specific binding proteins. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Analytical Toxicology Oxford University Press

Gentamicin and Tobramycin Binding to Human Serum In Vitro

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Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
Articles
ISSN
0146-4760
eISSN
1945-2403
DOI
10.1093/jat/28.3.187
Publisher site
See Article on Publisher Site

Abstract

The binding of gentamicin and tobramycin to human serum was studied in vitro using equilibrium dialysis of pooled human serum supplemented to various concentrations of either drug. Only minimal and variable non-specific binding was noted for each drug: gentamicin, less than 15% and tobramycin, less than 30%. Conventional Scatchard analysis conducted over an array of drug concentrations failed to identify any specific binding proteins.

Journal

Journal of Analytical ToxicologyOxford University Press

Published: Apr 1, 2004

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