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Michael Pennison, B. Pasche (2007)
Targeting transforming growth factor-β signalingCurrent Opinion in Oncology, 19
J. Moore, Scott Williams (2002)
New strategies for identifying gene-gene interactions in hypertensionAnnals of Medicine, 34
C. Coffey, P. Hebert, M. Ritchie, H. Krumholz, J. Gaziano, P. Ridker, N. Brown, D. Vaughan, J. Moore, Bmc Bioinformatics, M. Gaziano (2004)
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene Interactions on risk of myocardial infarction: The importance of model validationBMC Bioinformatics, 5
L. Yang, D. Parkin, L-D Li, YD Chen, F. Bray (2004)
Estimation and projection of the national profile of cancer mortality in China: 1991–2005British Journal of Cancer, 90
D. Parkin, F. Bray, J. Ferlay, P. Pisani (2005)
Global Cancer Statistics, 2002CA: A Cancer Journal for Clinicians, 55
(2008)
Received July
A. Zeidel, B. Beilin, I. Yardeni, E. Mayburd, Gennady Smirnov, Hanna Bessler (2002)
Immune response in asymptomatic smokersActa Anaesthesiologica Scandinavica, 46
Euskirchen (2004)
CREB binds to multiple loci on human chromosome 22Mol. Cell. Biol., 24
P. Brennan (2002)
Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it?Carcinogenesis, 23 3
D. Parkin (2004)
International variationOncogene, 23
S. Cohen, S. Johansson (1992)
Epidemiology and etiology of bladder cancer.Seminars in surgical oncology, 13 5
D. Hinds, L. Stuve, Geoffrey Nilsen, E. Halperin, E. Eskin, D. Ballinger, K. Frazer, D. Cox (2005)
Whole-Genome Patterns of Common DNA Variation in Three Human PopulationsScience, 307
S. Gabriel, S. Schaffner, Huy Nguyen, Jamie Moore, J. Roy, B. Blumenstiel, J. Higgins, M. Defelice, Amy Lochner, M. Faggart, S. Liu-Cordero, C. Rotimi, A. Adeyemo, R. Cooper, R. Ward, E. Lander, M. Daly, D. Altshuler (2002)
The Structure of Haplotype Blocks in the Human GenomeScience, 296
S. Bae, Joong-Kook Choi (2004)
Tumor suppressor activity of RUNX3Oncogene, 23
J. Barrett, B. Fry, J. Maller, M. Daly (2005)
Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 21 2
M. Ritchie, L. Hahn, Nady Roodi, L. Bailey, W. Dupont, F. Parl, J. Moore (2001)
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.American journal of human genetics, 69 1
A. Jemal, F. Bray, Melissa Center, J. Ferlay, Elizabeth Ward, D. Forman (2011)
Global cancer statisticsCA: A Cancer Journal for Clinicians, 61
Regina Armstrong, Regina Armstrong, Alain Migneault, Alain Migneault, Marya Shegog, Marya Shegog, Jin Kim, Jin Kim, Lynn Hudson, Lynn Hudson, Richard Hessler (1997)
High-grade human brain tumors exhibit increased expression of myelin transcription factor 1 (MYT1), a zinc finger DNA-binding protein.Journal of neuropathology and experimental neurology, 56 7
D. Schaid, C. Rowland, David Tines, R. Jacobson, G. Poland (2002)
Score tests for association between traits and haplotypes when linkage phase is ambiguous.American journal of human genetics, 70 2
D. Silverman, P. Hartge, A. Morrison, S. Devesa (1976)
Epidemiology of bladder cancer.The Urologic clinics of North America, 3 1
P. Hainaut, G. Pfeifer (2001)
Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke.Carcinogenesis, 22 3
Morihiko Sano, Nobuhiro Kuroi, T. Nakayama, N. Sato, Y. Izumi, M. Soma, S. Kokubun (2005)
Association study of calcitonin-receptor-like receptor gene in essential hypertension.American journal of hypertension, 18 3
M. Freedman, K. Penney, D. Stram, L. Marchand, J. Hirschhorn, L. Kolonel, D. Altshuler, B. Henderson, C. Haiman (2004)
Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort.Human molecular genetics, 13 20
Bixiang Zhang, S. Halder, Sanguo Zhang, P. Datta (2009)
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.Cancer letters, 277 1
D. Lehman, D. Fu, Angela Freeman, K. Hunt, R. Leach, T. Johnson-Pais, J. Hamlington, T. Dyer, R. Arya, H. Abboud, H. Göring, R. Duggirala, J. Blangero, R. Konrad, M. Stern (2005)
A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.Diabetes, 54 4
S. Cohen, T. Shirai, G. Steineck (2000)
Epidemiology and Etiology of Premalignant and Malignant Urothelial ChangesScandinavian Journal of Urology and Nephrology, 34
Cohen (1992)
Epidemiology and etiology of bladder cancerUrol. Clin. North Am., 19
S. Steiner (1979)
The Mexican Americans
Jin Kim, R. Armstrong, D. Agoston, Alexandra Robinsky, C. Wiese, J. Nagle, L. Hudson (1997)
Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous systemJournal of Neuroscience Research, 50
Qing-lin Li, Kosei Ito, C. Sakakura, H. Fukamachi, Ken-ichi Inoue, X. Chi, Kwang-Youl Lee, S. Nomura, C. Lee, S. Han, Hwan‐Mook Kim, Wun-Jae Kim, Hiromitsu Yamamoto, N. Yamashita, T. Yano, T. Ikeda, S. Itohara, J. Inazawa, T. Abe, A. Hagiwara, H. Yamagishi, Asako Ooe, Atsushi Kaneda, T. Sugimura, T. Ushijima, S. Bae, Yoshiaki Ito (2002)
Causal Relationship between the Loss of RUNX3 Expression and Gastric CancerCell, 109
D. Levanon, David Bettoun, C. Harris‐Cerruti, E. Woolf, V. Negreanu, R. Eilam, Y. Bernstein, D. Goldenberg, C. Xiao, M. Fliegauf, E. Kremer, F. Otto, O. Brenner, A. Lev-Tov, Y. Groner (2002)
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neuronsThe EMBO Journal, 21
B. Schmierer, C. Hill (2007)
TGFβ–SMAD signal transduction: molecular specificity and functional flexibilityNature Reviews Molecular Cell Biology, 8
Wun-Jae Kim, Eun-Jung Kim, P. Jeong, Changyi Quan, Jiyeon Kim, Qing-lin Li, Jeong-Ook Yang, Yoshiaki Ito, S. Bae (2005)
RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors.Cancer research, 65 20
A. Lund, M. Lohuizen (2002)
RUNX: a trilogy of cancer genes.Cancer cell, 1 3
C. Carlson, M. Eberle, M. Rieder, Q. Yi, L. Kruglyak, D. Nickerson (2004)
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium.American journal of human genetics, 74 1
S. Qi (2005)
Relationship between RUNX3 gene 364 locus C→T mutation and gastric cancer in ChineseChinese Journal of Pathophysiology
K. Aben, L. Kiemeney (1999)
Epidemiology of Bladder CancerEuropean Urology, 36
Meilin Wang, Zhizhong Zhang, Haixia Zhu, G. Fu, Shouyu Wang, Dongmei Wu, Jianwei Zhou, Q. Wei, Zhengdong Zhang (2008)
A Novel Functional Polymorphism C1797G in the MDM2 Promoter Is Associated with Risk of Bladder Cancer in a Chinese PopulationClinical Cancer Research, 14
A. Weith, G. Brodeur, G. Bruns, T. Matise, D. Mischke, D. Nižetić, M. Seldin, N. Roy, J. Vance (1996)
Report of the second international workshop on human chromosome 1 mapping 1995.Cytogenetics and cell genetics, 72 2-3
(2003)
Copyright © 2004, American Society for Microbiology. All Rights Reserved. CREB Binds to Multiple Loci on Human Chromosome 22
L. Hahn, M. Ritchie, J. Moore (2003)
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactionsBioinformatics, 19 3
C. Bangsow, N. Rubins, Gwênlyn Glusman, Y. Bernstein, V. Negreanu, D. Goldenberg, J. Lotem, E. Ben‐Asher, D. Lancet, D. Levanon, Y. Groner (2001)
The RUNX3 gene--sequence, structure and regulated expression.Gene, 279 2
Transforming growth factor- (TGF-) is a multifunctional growth factor that plays important roles in many biological processes, whereas RUNX3 is a target of TGF--mediated tumor suppressor pathway. In humans, RUNX3 inactivation may lead to the cancer development, including bladder cancer. To determine whether the RUNX3 polymorphisms are associated with risk of bladder cancer, we conducted a casecontrol study of 368 bladder cancer patients and 368 cancer-free controls to assess the associations between the RUNX3 tagging single-nucleotide polymorphisms (tSNPs) and bladder cancer risk. In the single-locus analysis, we found a significantly increased risk of bladder cancer associated with the SNP7 rs760805 AA genotype (adjusted odds ratio 1.97, 95% confidence interval 1.442.69), compared with the AT/TT genotype. Haplotype-based association analysis revealed that the increased risk of bladder cancer was significantly associated with two haplotypes TATCCCAAAA (2.37, 1.164.83) and AGCTTGAGAG (2.70, 1.086.72) that included the rs760805 A allele. Multifactor dimensionality reduction (MDR) analysis identified a significant more than multiplicative interaction between the SNP7 rs760805 AA and smoking and an additive interaction between the SNP3 rs11249206 TT and smoking on bladder cancer risk. The SNP3 rs11249206, SNP5 rs1395621, SNP7 rs760805, SNP8 rs2236852 and the trichotomized cumulative smoking were the five factors best predicted by the MDR models. When the variables were combined and dichotomized and fitted into the MDR model, the subjects carrying the combined risk stratum had a significantly increased risk for bladder cancer (6.37, 4.578.87, P7.031028). These results suggested that the genetic variants in RUNX3 may modulate the risk of bladder cancer.
Carcinogenesis – Oxford University Press
Published: Aug 5, 2008
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