Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/oxford-university-press/effects-of-sex-and-age-on-bone-microstructure-at-the-ultradistal-vApln1W5ir
References (32)
-
S. Khosla, B. Riggs, R. Robb, J. Camp, S. Achenbach, A. Oberg, Peggy Rouleau, L. Melton (2005)
Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women.The Journal of clinical endocrinology and metabolism, 90 9
-
T. Hildebrand, A. Laib, Ralph Müller, J. Dequeker, P. Rüegsegger (1999)
Direct Three‐Dimensional Morphometric Analysis of Human Cancellous Bone: Microstructural Data from Spine, Femur, Iliac Crest, and CalcaneusJournal of Bone and Mineral Research, 14
-
R. Müller, T. Hildebrand, H. Häuselmann, P. Rüegsegger (1996)
In vivo reproducibility of three‐dimensional structural properties of noninvasive bone biopsies using 3D‐pQCTJournal of Bone and Mineral Research, 11
-
A. Laib, P. Rüegsegger (1999)
Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography.Bone, 24 1
-
S. Majumdar, H. Genant, Stephan Grampp, D. Newitt, V. Truong, J. Lin, A. Mathur (1997)
Correlation of Trabecular Bone Structure with Age, Bone Mineral Density, and Osteoporotic Status: In Vivo Studies in the Distal Radius Using High Resolution Magnetic Resonance ImagingJournal of Bone and Mineral Research, 12
-
Cooper Cooper, Melton Melton (1992)
Epidemiology of osteoporosisTrends Endocrinol Metab, 3
-
L. Melton (1996)
History of the Rochester Epidemiology Project.Mayo Clinic proceedings, 71 3
-
(2000)
Longitudinal changes between premenopausal and postmenopausal in three-dimensional trabecular microstructural characteristics of human iliac crest bone biopsies -
A. Laib, H. Häuselmann, P. Rüegsegger (1998)
In vivo high resolution 3D-QCT of the human forearm.Technology and health care : official journal of the European Society for Engineering and Medicine, 6 5-6
-
B. Riggs, L. Melton, R. Robb, J. Camp, E. Atkinson, J. Peterson, Peggy Rouleau, C. McCollough, M. Bouxsein, S. Khosla (2004)
Population‐Based Study of Age and Sex Differences in Bone Volumetric Density, Size, Geometry, and Structure at Different Skeletal SitesJournal of Bone and Mineral Research, 19
-
D. Meier, E. Orwoll, E. Keenan, R. Fagerstrom (1987)
Marked Decline in Trabecular Bone Mineral Content in Healthy Men with Age: Lack of Association with Sex Steroid LevelsJournal of the American Geriatrics Society, 35
-
K. Jordan, Chris Cooper (1996)
THE EPIDEMIOLOGY OF OSTEOPOROSISInternational Journal of Clinical Practice, 50
-
S. Khosla, L. Melton, R. Robb, J. Camp, E. Atkinson, A. Oberg, Peggy Rouleau, B. Riggs (2004)
Relationship of Volumetric BMD and Structural Parameters at Different Skeletal Sites to Sex Steroid Levels in MenJournal of Bone and Mineral Research, 20
-
Paul Miller, Carol Zapalowski, Carolina Kulak, J. Bilezikian (1999)
Bone densitometry: the best way to detect osteoporosis and to monitor therapy.The Journal of clinical endocrinology and metabolism, 84 6
-
M. Bouxsein (2001)
Biomechanics of Age-Related Fractures -
Liang Yu (2002)
Structure Analysis of the WasLiaoning Chemical Industry
-
J. Aaron, N. Makins, K. Sagreiya (1987)
The microanatomy of trabecular bone loss in normal aging men and women.Clinical orthopaedics and related research, 215
-
Parfitt Parfitt, Mathews Mathews, Villanueva Villanueva, Kleerekoper Kleerekoper, Frame Frame, Rao Rao (1983)
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosisCalcif Tissue Int, 72
-
A. Laib, T. Hildebrand, H. Häuselmann, P. Rüegsegger (1997)
Ridge number density: a new parameter for in vivo bone structure analysis.Bone, 21 6
-
W. Venables, B. Ripley (1996)
Modern Applied Statistics with S-Plus.Biometrics, 52
-
A. Parfitt, C. Mathews, Villanueva Ar, Michael Kleerekoper, Boy Frame, D. Rao (1983)
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.The Journal of clinical investigation, 72 4
-
T. Dufresne, P. Chmielewski, M. Manhart, T. Johnson, B. Borah (2003)
Risedronate Preserves Bone Architecture in Early Postmenopausal Women In 1 Year as Measured by Three-Dimensional Microcomputed TomographyCalcified Tissue International, 73
-
S. Khosla, L. Melton, E. Atkinson, W. O'Fallon (2001)
Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men.The Journal of clinical endocrinology and metabolism, 86 8
-
Parfitt Parfitt, Mathews Mathews, Villaneuva Villaneuva, Kleerekoper Kleerekoper, Frame Frame, Rao Rao (1983)
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosisJ Clin Invest, 72
-
B. Riggs, A. Parfitt (2004)
Drugs Used to Treat Osteoporosis: The Critical Need for a Uniform Nomenclature Based on Their Action on Bone RemodelingJournal of Bone and Mineral Research, 20
-
Matthew Silva, Lorna Gibson (1997)
Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related changes in microstructure.Bone, 21 2
-
M. Ito, Toshitaka Nakamura, K. Tsurusaki, M. Uetani, Kuniaki Hayashi (1999)
Effects of Menopause on Age-Dependent Bone Loss in the Axial and Appendicular Skeletons in Healthy Japanese WomenOsteoporosis International, 10
-
(2005)
Substantial trabecular bone loss occurs in young adult women and men: A population-based longitudinal study -
Zhan-hong Han, S. Palnitkar, D. Rao, A. Parfitt, D. Nelson (1996)
Effect of ethnicity and age or menopause on the structure and geometry of iliac boneJournal of Bone and Mineral Research, 11
-
K. Tsurusaki, M. Ito, K. Hayashi (2000)
Differential effects of menopause and metabolic disease on trabecular and cortical bone assessed by peripheral quantitative computed tomography (pQCT).The British journal of radiology, 73 865
-
R. Müller, T. Hildebrand, P. Rüegsegger (1994)
Non-invasive bone biopsy: a new method to analyse and display the three-dimensional structure of trabecular bone.Physics in medicine and biology, 39 1
-
W. Yu, M. Qin, Ling Xu, C. Kuijk, X. Meng, X. Xing, J. Cao, H. Genant (1999)
Normal Changes in Spinal Bone Mineral Density in a Chinese Population: Assessment by Quantitative Computed Tomography and Dual-Energy X-ray AbsorptiometryOsteoporosis International, 9
- Publisher
- Oxford University Press
- Copyright
- Copyright © 2006 ASBMR
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- DOI
- 10.1359/jbmr.050916
- Publisher site
- See Article on Publisher Site
Abstract
In a population‐based cross‐sectional study, we examined effects of sex and age on bone microstructure at the wrist using high‐resolution 3‐D pQCT. Compared with women, men had thicker trabeculae in young adulthood and had less microstructural damage with aging. These findings may contribute to the virtual immunity of men to age‐related increases in wrist fractures.Introduction: Although changes in bone microstructure contribute to fracture risk independently of BMD, it has not heretofore been possible to assess this noninvasively in population‐based studies.Materials and Methods: We used high‐resolution 3‐D pQCT imaging (voxel size, 89 μm) to define, in a random sample of women (n = 324) and men (n = 278) 21–97 years of age, sex and age effects on bone microstructure at the wrist.Results: Relative to young women (age, 20–29 years), young men had greater trabecular bone volume/tissue volume (BV/TV; by 26%, p = 0.001) and trabecular thickness (TbTh; by 28%, p < 0.001) but similar values for trabecular number (TbN) and trabecular separation (TbSp). Between ages 20 and 90 years, cross‐sectional decreases in BV/TV were similar in women (−27%) and in men (−26%), but whereas women had significant decreases in TbN (−13%) and increases in TbSp (+24%), these parameters had little net change over life in men (+7% and −2% for TbN and TbSp, respectively; p < 0.001 versus women). However, TbTh decreased to a greater extent in men (−24%) than in women (−18%; p = 0.010 versus men).Conclusions: Whereas decreases with age in trabecular BV/TV are similar in men and women, the structural basis for the decrease in trabecular volume is quite different between the sexes. Thus, over life, women undergo loss of trabeculae with an increase in TbSp, whereas men begin young adult life with thicker trabeculae and primarily sustain trabecular thinning with no net change in TbN or TbSp. Because decreases in TbN have been shown to have a much greater impact on bone strength compared with decreases in TbTh, these findings may help explain the lower life‐long risk of fractures in men, and specifically, their virtual immunity to age‐related increases in distal forearm fractures.
Journal
Journal of Bone and Mineral Research – Oxford University Press
Published: Dec 4, 2009
Keywords: osteoporosis; aging; bone structure; pQCT