Clinical Infectious Diseases EDIT ORIAL C OMMENTAR Y Polymerase Chain Reaction for the tpp47 Gene: A New Test for Neurosyphilis Daniel M. Musher Baylor College of Medicine and Medical Care Line, Infectious Disease Section, Michael E. DeBakey Medical Center, Houston, Texas (See the Major Article by Vanhaecke et al on pages 1180–6.) Keywords. syphilis; neurosyphilis; syphilitic meningitis. The Holy Grail of neurosyphilis is a spe- veriﬁcation, it might have been of great What are the origins of the mis- ciﬁc and sensitive diagnostic test that can interest for Vanhaecke et al to apply conception that the CSF VDRL may be be done on cerebrospinal ﬂuid (CSF) to their CSF PCR in patients with primary nonreactive in up to 70% of cases of neuro- diagnosis this disease. The goal of the or secondary syphilis. syphilis? I believe there are 2. First, in 1973, study by Vanhaecke et al, reported in Neurosyphilis, symptomatic involve- Hooshmand et al  reported 241 cases this issue of Clinical Infectious Diseases, ment of the central nervous system in in which they diagnosed neurosyphilis. was to study the utility of polymerase the late (tertiary) stages of syphilis, was Diagnosis was accepted in patients with chain reaction
Clinical Infectious Diseases – Oxford University Press
Published: Nov 1, 2016
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