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- Publisher
- Oxford University Press
- Copyright
- Copyright © 2015 Oxford University Press
- ISSN
- 0144-8420
- eISSN
- 1742-3406
- DOI
- rpd;88/1/21
- Publisher site
- See Article on Publisher Site
Abstract
In order to evaluate the practicality of FISH (fluorescence in situ hybridisation) chromosome painting for retrospective biodosimetry, more information on the stability of translocations with time and the control level of translocations is needed. The temporal behaviour of translocation frequency in four accidentally exposed subjects showed that translocations remained relatively stable throughout the first post-accidental years. A decline in translocation yields was, however, observed in one subject exposed to both high dose and partial body irradiation that lead to severe aplasia. This finding implies that FISH biodosimetry may not be informative in cases where the dose has not been uniformly distributed. In our studies, significant age dependence and wide translocation range has been observed. In dose assessment of low dose exposure to a large number of people the age effect has been accounted for by comparing the results with a matched control group. Our data support the use of translocations for retrospective dosimetry for moderately high doses of the order of 1 Gy acute exposure with uniform whole-body exposures. In low dose chronic exposures, reliable assessment of past exposures can be achieved on group level. Radiation Protection Dosimetry « Previous | Next Article » Table of Contents This Article Radiat Prot Dosimetry (2000) 88 (1): 21-25. » Abstract Free Full Text (PDF) Free Classifications Article Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Lindholm, C. Articles by Salomaa, S. Search for related content PubMed Articles by Lindholm, C. Articles by Salomaa, S. 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Journal
Radiation Protection Dosimetry – Oxford University Press
Published: Mar 1, 2000