Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the National Health and Nutrition Examination Surveys (NHANES) 1999-2002

Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the... Abstract Aging is the biggest risk factor for the development of chronic diseases. Telomere length may represent one important mechanism by which dietary intake influences age-related diseases; however, it is unknown which diet pattern is most strongly related to telomere length. We compared the relations between four evidence-based diet quality indices and leukocyte telomere length in a nationally representative sample of healthy adults, and the extent to which these associations differ between men and women. Data came from 4,758 adults, aged 20-65 years, with no prior diagnosis of major chronic disease, from the 1999-2002 National Health and Nutrition Examination Surveys (NHANES). Diet was assessed using one 24-hour dietary recall. After adjusting for sociodemographic and health characteristics, comparing the top and bottom quintiles showed that higher Healthy Eating Index-2010 (β=0.065, 95% CI 0.018, 0.112, P-trend=0.007), AHEI-2010 scores (β=0.054, 95% CI 0.010, 0.097, P-trend=0.007), Mediterranean Diet scores (β=0.058, 95% CI 0.017, 0.098, P-trend=0.008), and Dietary Approaches to Stopping Hypertension (DASH) scores (β=0.052, 95% CI 0.014, 0.090, P-trend=0.007) were each associated with longer telomere length in women. These results may provide insight into the complex associations between optimal nutrition and longevity. Further investigation is needed to understand why associations were not observed in men. leukocyte telomere length, cellular aging, diet patterns, Healthy Eating Index, Alternate Healthy Eating Index, Mediterranean Diet Score, Dietary Approaches to Stop Hypertension score © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Epidemiology Oxford University Press

Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the National Health and Nutrition Examination Surveys (NHANES) 1999-2002

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Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
ISSN
0002-9262
eISSN
1476-6256
D.O.I.
10.1093/aje/kwy124
Publisher site
See Article on Publisher Site

Abstract

Abstract Aging is the biggest risk factor for the development of chronic diseases. Telomere length may represent one important mechanism by which dietary intake influences age-related diseases; however, it is unknown which diet pattern is most strongly related to telomere length. We compared the relations between four evidence-based diet quality indices and leukocyte telomere length in a nationally representative sample of healthy adults, and the extent to which these associations differ between men and women. Data came from 4,758 adults, aged 20-65 years, with no prior diagnosis of major chronic disease, from the 1999-2002 National Health and Nutrition Examination Surveys (NHANES). Diet was assessed using one 24-hour dietary recall. After adjusting for sociodemographic and health characteristics, comparing the top and bottom quintiles showed that higher Healthy Eating Index-2010 (β=0.065, 95% CI 0.018, 0.112, P-trend=0.007), AHEI-2010 scores (β=0.054, 95% CI 0.010, 0.097, P-trend=0.007), Mediterranean Diet scores (β=0.058, 95% CI 0.017, 0.098, P-trend=0.008), and Dietary Approaches to Stopping Hypertension (DASH) scores (β=0.052, 95% CI 0.014, 0.090, P-trend=0.007) were each associated with longer telomere length in women. These results may provide insight into the complex associations between optimal nutrition and longevity. Further investigation is needed to understand why associations were not observed in men. leukocyte telomere length, cellular aging, diet patterns, Healthy Eating Index, Alternate Healthy Eating Index, Mediterranean Diet Score, Dietary Approaches to Stop Hypertension score © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

American Journal of EpidemiologyOxford University Press

Published: Jun 15, 2018

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