Access the full text.
Sign up today, get DeepDyve free for 14 days.
Vandewalle-Capo (2017)
684Int J Antimicrob Agents, 50
Heng Li (2017)
Minimap2: pairwise alignment for nucleotide sequencesBioinformatics, 34
K. Sreenath, R. Chaudhry, E. Vinayaraj, B. Thakur (2019)
Antibiotic susceptibility of environmental Legionella pneumophila isolated in India.Future microbiology, 14
C. Pouderoux, C. Ginevra, G. Descours, A. Ranc, L. Beraud, S. Boisset, N. Magand, A. Conrad, A. Bergeron-Lafaurie, S. Jarraud, F. Ader (2020)
Slowly or non-resolving Legionnaires' disease: case series and literature review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Agnieszka Sikora, I. Gładysz, M. Kozioł-Montewka, Małgorzata Wójtowicz-Bobin, T. Stańczak, R. Matuszewska, B. Krogulska (2017)
Assessment of antibiotic susceptibility of Legionella pneumophila isolated from water systems in Poland.Annals of agricultural and environmental medicine : AAEM, 24 1
C. Ginevra, Marie Lopez, F. Forey, M. Reyrolle, H. Meugnier, F. Vandenesch, J. Etienne, S. Jarraud, M. Molmeret (2009)
Evaluation of a Nested-PCR-Derived Sequence-Based Typing Method Applied Directly to Respiratory Samples from Patients with Legionnaires' DiseaseJournal of Clinical Microbiology, 47
Nielsen (2000)
43Diagn Microbiol Infect Dis, 36
Portal (2021)
1197J Antimicrob Chemother, 76
Bruin (2013)
339Diagn Microbiol Infect Dis, 76
Ji Lu, Yue Wang, Jie Li, Likai Mao, S. Nguyen, T. Duarte, L. Coin, P. Bond, Zhiguo Yuan, Jianhua Guo (2018)
Triclosan at environmentally relevant concentrations promotes horizontal transfer of multidrug resistance genes within and across bacterial genera.Environment international, 121 Pt 2
O. Natås, Anita Brekken, E. Bernhoff, M. Hetland, I. Löhr, P. Lindemann (2019)
Susceptibility of Legionella pneumophila to antimicrobial agents and the presence of the efflux pump LpeAB.The Journal of antimicrobial chemotherapy, 74 6
G. Descours, C. Ginevra, Nathalie Jacotin, F. Forey, J. Chastang, E. Kay, J. Etienne, G. Lina, P. Doublet, S. Jarraud (2017)
Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophilaAntimicrobial Agents and Chemotherapy, 61
Almahmoud (2009)
284J Antimicrob Chemother, 64
T. Rowbotham (1998)
Isolation of Legionella pneumophila serogroup 1 from human feces with use of amebic cocultures.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 26 2
J. Bruin, Tetyana Koshkolda, E. Ijzerman, C. Lück, B. Diederen, J. Boer, J. Mouton (2014)
Isolation of ciprofloxacin-resistant Legionella pneumophila in a patient with severe pneumonia.The Journal of antimicrobial chemotherapy, 69 10
Torre (2018)
574Environ Res, 164
Cocuzza (2021)
9352Int J Environ Res Public Health, 18
Nielsen (2000)
2679Antimicrob Agents Chemother, 44
Graells (2018)
638Environ Res, 166
Kun Wang, Taotao Zhuang, Zhaoxin Su, Menghao Chi, Haichao Wang (2021)
Antibiotic residues in wastewaters from sewage treatment plants and pharmaceutical industries: Occurrence, removal and environmental impacts.The Science of the total environment, 788
Bruin (2014)
2869J Antimicrob Chemother, 69
Y. Sharaby, O. Nitzan, I. Brettar, M. Höfle, A. Peretz, M. Halpern (2019)
Antimicrobial agent susceptibilities of Legionella pneumophila MLVA-8 genotypesScientific Reports, 9
Guidance document on Antimicrobial Susceptibility Testing of Legionella pneumophila
Miyashita (2018)
325J Infect Chemother, 24
Rowbotham (1998)
502Clin Infect Dis, 26
Pouderoux (2020)
1933Clin Infect Dis, 70
Kim Nielsen, J. Bangsborg, N. Høiby (2000)
Susceptibility of Legionella species to five antibiotics and development of resistance by exposure to erythromycin, ciprofloxacin, and rifampicin.Diagnostic microbiology and infectious disease, 36 1
Wang (2021)
147811Sci Total Environ, 788
E. Portal, K. Sands, Artjoms Portnojs, V. Chalker, O. Spiller (2020)
Legionella antimicrobial sensitivity testing: comparison of microbroth dilution with BCYE and LASARUS solid mediaJournal of Antimicrobial Chemotherapy, 76
I. Torre, R. Alfano, T. Borriello, O. Giglio, C. Iervolino, M. Montagna, M. Scamardo, F. Pennino (2018)
Environmental surveillance and in vitro activity of antimicrobial agents against Legionella pneumophila isolated from hospital water systems in Campania, South Italy: a 5‐year studyEnvironmental Research, 164
E. Portal, G. Descours, C. Ginevra, M. Mentasti, B. Afshar, M. Chand, J. Day, F. Echahidi, L. Franzin, V. Gaia, C. Lück, A. Meghraoui, J. Moran-Gilad, M. Ricci, G. Lina, S. Uldum, J. Winchell, R. Howe, K. Bernard, O. Spiller, V. Chalker, S. Jarraud, Catherine Ahlen, Ibrahim Hashmi, G. Allestam, J. Amemura-Maekawa, S. Andersson, J. Bangsborg, Sheila Bararossa, L. Beraud, K. Bernard, P. Borella, P. Brandsema, J. Bruin, A. Buzzigoli, R. Cano, B. Casini, G. Celenza, Vicki Chalker, S. Collins, Sebastian Rotger, M. Cristina, S. Cristino, S. David, B. Jong, J. Boer, F. Echahidi, P. Elverdal, H. Erdoğan, S. Euser, L. Franzin, N. Fry, V. Gaia, M. García-nuñez, C. Ginevra, Elsa Concalves, P. Gonçalves, Tiscar Fernandez, A. Grottola, Nicole Gysin, T. Harrison, M. Höfle, S. Jarraud, C. Jørgensen, C. Joseph, Björn Kanto, D. Keše, Louise Kindingstad, D. Klingenberg, Mehmet Kösekul, N. Kozak-Muiznieks, F. Kura, J. Kusnetsov, Sandra Lai, Susanne Lee, John Lee, D. Lindsay, C. Lück, Marcel Leuscher, Wilco Lugt, M. Marques, M. Meacci, A. Meghraoui, M. Mentasti, S. Mentula, Antonija Mikrut, J. Mòdol, Ginny Moore, J. Moran-Gilad, M. Morin, Selin Otgun, O. Nataas, Neda Abadi, K. Pancer, M. Pecorari, M. Pedro-Botet, C. Peláz, Markus Petzold, Nicholas Pissarides, E. Portal, M. Ramliden, Brian Raphael, Kate Reddington, M. Ricci, E. Robesyn, S. Roisin, F. Rumpianesi, Henri Saenz, M. Scaturro, J. Schalk, Graf Simone, Stine Bjerregaard, A. Spagnolo, O. Spiller, A. Aspelund, Christina Svarrer, Igor Tartakovshiy, K. Templeton, S. Uldum, E. Veschetti, James Walker, F. Wallet, G. Wewalka, C. Whapham, Anika Wunderlich, I. Wybo (2021)
Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance?The Journal of antimicrobial chemotherapy
Li (2018)
3094Bioinformatics, 34
Descours (2017)
e02188-16Antimicrob Agents Chemother, 61
Marine Vandewalle-Capo, Clémence Massip, G. Descours, Joséphine Charavit, J. Chastang, P. Billy, S. Boisset, G. Lina, C. Gilbert, M. Maurin, S. Jarraud, C. Ginevra (2017)
Minimum inhibitory concentration (MIC) distribution among wild-type strains of Legionella pneumophila identifies a subpopulation with reduced susceptibility to macrolides owing to efflux pump genes.International journal of antimicrobial agents, 50 5
Shadoud (2015)
1179EBioMedicine, 2
Samreen (2021)
101J Glob Antimicrob Resist, 27
J. Bruin, B. Diederen, E. Ijzerman, J. Boer, J. Mouton (2013)
Correlation of MIC value and disk inhibition zone diameters in clinical Legionella pneumophila serogroup 1 isolates.Diagnostic microbiology and infectious disease, 76 3
Sreenath (2019)
661Future Microbiol, 14
Erik Garrison, G. Marth (2012)
Haplotype-based variant detection from short-read sequencingarXiv: Genomics
C. Cocuzza, M. Martinelli, Federica Perdoni, Chiara Giubbi, Maria Vinetti, E. Calaresu, S. Frugoni, M. Scaturro, M. Ricci, R. Musumeci (2021)
Antibiotic Susceptibility of Environmental Legionella pneumophila Strains Isolated in Northern ItalyInternational Journal of Environmental Research and Public Health, 18
Alexandropoulou (2019)
39Healthcare (Basel), 7
Samreen, I. Ahmad, H. Malak, H. Abulreesh (2021)
Environmental antimicrobial resistance and its drivers: A potential threat to public health.Journal of global antimicrobial resistance
Iyad Almahmoud, E. Kay, D. Schneider, M. Maurin (2009)
Mutational paths towards increased fluoroquinolone resistance in Legionella pneumophila.The Journal of antimicrobial chemotherapy, 64 2
Portal (2021)
1113J Antimicrob Chemother, 76
I. Alexandropoulou, Theodoros Parasidis, Theocharis Konstantinidis, M. Panopoulou, T. Constantinidis (2019)
A Proactive Environmental Approach for Preventing Legionellosis in Infants: Water Sampling and Antibiotic Resistance Monitoring, a 3-Years Survey ProgramHealthcare, 7
Sharaby (2019)
6138Sci Rep, 9
Ginevra (2009)
981J Clin Microbiol, 47
Sikora (2017)
66Ann Agric Environ Med, 24
Garrison (2012)
3907arXiv, 1207
Tiscar Graells, M. Hernández-García, J. Pérez-Jové, L. Guy, E. Padilla (2018)
Legionella pneumophila recurrently isolated in a Spanish hospital: Two years of antimicrobial resistance surveillanceEnvironmental Research, 166
K. Nielsen, P. Hindersson, N. Høiby, J. Bangsborg (2000)
Sequencing of the rpoB Gene inLegionella pneumophila and Characterization of Mutations Associated with Rifampin Resistance in theLegionellaceaeAntimicrobial Agents and Chemotherapy, 44
Natås (2019)
1545J Antimicrob Chemother, 74
Lu (2018)
1217Environ Int, 121
Lubana Shadoud, Iyad Almahmoud, S. Jarraud, J. Etienne, S. Larrat, C. Schwebel, J. Timsit, D. Schneider, M. Maurin (2015)
Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and HumansEBioMedicine, 2
N. Miyashita, I. Kobayashi, F. Higa, Y. Aoki, T. Kikuchi, M. Seki, K. Tateda, Nobuko Maki, K. Uchino, K. Ogasawara, Satoe Kurachi, T. Ishikawa, Yoshito Ishimura, Izumo Kanesaka, H. Kiyota, A. Watanabe (2018)
In vitro activity of various antibiotics against clinical strains of Legionella species isolated in Japan.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 24 5
ObjectivesImplementation of an antibiotic resistance detection tool in Legionella daily surveillance at the French National Reference Centre for Legionella.MethodsSystematic WGS of Legionella pneumophila isolates and bioinformatics detection of specific mutations linked to antibiotic resistance. Phenotypic validation of antibiotic resistance detected by WGS was performed by the broth microdilution method.ResultsMore than 3000 L. pneumophila strains were screened for antibiotic resistance. A macrolide resistance-associated A2052G mutation in the 23S rRNA gene was identified in the genome of eight isolates from a hotel water network. High-level macrolide resistance (i.e. MICs of 1024–2048 mg/L for azithromycin and erythromycin) with no cross-resistance to other antimicrobials was phenotypically confirmed by antimicrobial susceptibility testing for the eight isolates.ConclusionsSystematic WGS of L. pneumophila is a powerful tool for first-line high-throughput screening of antibiotic resistance before phenotypic validation.
Journal of Antimicrobial Chemotherapy – Oxford University Press
Published: Jun 9, 2022
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.