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O. Noga, M. Peiser, M. Altenähr, H. Knieling, R. Wanner, G. Hanf, R. Grosse, N. Suttorp (2007)
Differential activation of dendritic cells by nerve growth factor and brain‐derived neurotrophic factorClinical & Experimental Allergy, 37
M. Lechmann, S. Berchtold, J. Hauber, A. Steinkasserer (2002)
CD83 on dendritic cells: more than just a marker for maturation.Trends in immunology, 23 6
Khaleque Khan, H. Masuzaki, A. Fujishita, Michio Kitajima, I. Sekine, T. Ishimaru (2004)
Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum.Fertility and sterility, 81 3
Irene Velasco, F. Quereda, R. Bermejo, Adolfo Campos, P. Acién (2007)
Intraperitoneal recombinant interleukin-2 activates leukocytes in rat endometriosis.Journal of reproductive immunology, 74 1-2
Å. Bengtsson, E. Ryan, D. Giordano, D. Magaletti, E. Clark (2004)
17-ß-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells Short title: The effect of 17-ß-estradiol on dendritic cells
S. Dunzendorfer, A. Kaser, C. Meierhofer, H. Tilg, C. Wiedermann (2001)
Cutting Edge: Peripheral Neuropeptides Attract Immature and Arrest Mature Blood-Derived Dendritic Cells1The Journal of Immunology, 166
Y. Antsiferova, N. Sotnikova, L. Posiseeva, A. Shor (2005)
Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis.Fertility and sterility, 84 6
L. Mettler, N. Volkov, V. Kulakov, A. Jürgensen, M. Parwaresch (1996)
Lymphocyte Subsets in the Endometrium of Patients With Endometriosis Throughout the Menstrual CycleAmerican Journal of Reproductive Immunology, 36
A. Prechtel, A. Steinkasserer (2007)
CD83: an update on functions and prospects of the maturation marker of dendritic cellsArchives of Dermatological Research, 299
K. Sharpe-Timms, P. Bruno, L. Penney, J. Bickel (1994)
Immunohistochemical localization of granulocyte-macrophage colony-stimulating factor in matched endometriosis and endometrial tissues.American journal of obstetrics and gynecology, 171 3
G. Nalbandian, S. Kovats (2005)
Understanding sex biases in immunityImmunologic Research, 31
N. Sinaii, S. Cleary, M. Ballweg, L. Nieman, P. Stratton (2002)
High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.Human reproduction, 17 10
S. Mathur (2000)
Autoimmunity in Endometriosis: Relevance to InfertilityAmerican Journal of Reproductive Immunology, 44
H. Ota, S. Igarashi, Toshinobu Tanaka (1996)
Expression of γδT Cells and Adhesion Molecules in Endometriotic Tissue in Patients With Endometriosis and AdenomyosisAmerican Journal of Reproductive Immunology, 35
L. Krenács, L. Tiszalvicz, T. Krenács, L. Boumsell (1993)
Immunohistochemical detection of cd1a antigen in formalin‐fixed and paraffin‐embedded tissue sections with monoclonal antibody 010The Journal of Pathology, 171
S. Fernández-Shaw, M. Clarke, B. Hicks, C. Naish, D. Barlow, P. Starkey (1995)
Bone marrow-derived cell populations in uterine and ectopic endometrium.Human reproduction, 10 9
G. Hughes, E. Clark (2007)
Regulation of dendritic cells by female sex steroids: Relevance to immunity and autoimmunityAutoimmunity, 40
D. Lebovic, M. Mueller, R. Taylor (2001)
Immunobiology of endometriosis.Fertility and sterility, 75 1
D. Ding, H. Mehta, W. Mccune, M. Kaplan (2006)
Aberrant Phenotype and Function of Myeloid Dendritic Cells in Systemic Lupus Erythematosus1The Journal of Immunology, 177
S. Blois, U. Kammerer, C. Soto, M. Tometten, V. Shaikly, G. Barrientos, R. Jurd, D. Rukavina, A. Thomson, B. Klapp, N. Fernández, P. Arck (2007)
Dendritic Cells: Key to Fetal Tolerance?1, 77
O. Fainaru, A. Adini, Ofra Benny, I. Adini, S. Short, L. Bazinet, K. Nakai, Elke Pravda, M. Hornstein, R. D'Amato, J. Folkman (2008)
Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosisThe FASEB Journal, 22
Rebecca Jones, Judith Bulmer, R. Searle (1998)
Phenotypic and functional studies of leukocytes in human endometrium and endometriosis.Human reproduction update, 4 5
H. Ota, S. Igarashi, T. Tanaka (1996)
Expression of gamma delta T cells and adhesion molecules in endometriotic tissue in patients with endometriosis and adenomyosis.American journal of reproductive immunology, 35 5
L. Klentzeris, J. Bulmer, D. Liu, L. Morrison (1995)
Endometrial leukocyte subpopulations in women with endometriosis.European journal of obstetrics, gynecology, and reproductive biology, 63 1
L. Schulke, F. Manconi, R. Markham, I. Fraser (2008)
Endometrial dendritic cell populations during the normal menstrual cycle.Human reproduction, 23 7
D. Nagorsen, F. Marincola, M. Panelli (2004)
Cytokine and chemokine expression profiles of maturing dendritic cells using multiprotein platform arrays.Cytokine, 25 1
W. Dmowski, D. Braun (2004)
Immunology of endometriosis.Best practice & research. Clinical obstetrics & gynaecology, 18 2
Å. Bengtsson, E. Ryan, D. Giordano, D. Magaletti, E. Clark (2004)
17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.Blood, 104 5
N. Johnson, Cindy Farquhar, W. Hadden, J. Suckling, Y. Yu, L. Sadler (2004)
The FLUSH trial--flushing with lipiodol for unexplained (and endometriosis-related) subfertility by hysterosalpingography: a randomized trial.Human reproduction, 19 9
N. Tokushige, R. Markham, Pamela Russell, Ian Fraser (2006)
High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis.Human reproduction, 21 3
D. Gagné, M. Rivard, M. Pagé, Manon Lépine, C. Platon, K. Shazand, P. Hugo, D. Gosselin (2003)
Development of a nonsurgical diagnostic tool for endometriosis based on the detection of endometrial leukocyte subsets and serum CA-125 levels.Fertility and sterility, 80 4
I. Szabo, Xiaohong Chen, L. Xin, M. Adler, O. Howard, J. Oppenheim, T. Rogers (2002)
Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of painProceedings of the National Academy of Sciences of the United States of America, 99
C. Siristatidis, C. Nissotakis, C. Chrelias, Helen Iacovidou, E. Salamalekis (2006)
Immunological factors and their role in the genesis and development of endometriosis ARTICLE HAS BEEN RETRACTEDJournal of Obstetrics and Gynaecology Research, 32
J. Keenan, P. Williams-Boyce, P. Massey, T. Chen, M. Caudle, A. Bukovsky (1999)
Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole.Fertility and sterility, 72 1
L. Salamonsen (2003)
Tissue injury and repair in the female human reproductive tract.Reproduction, 125 3
R. Jones, J. Bulmer, R. Searle (1995)
Immunohistochemical characterization of proliferation, oestrogen receptor and progesterone receptor expression in endometriosis: comparison of eutopic and ectopic endometrium with normal cycling endometrium.Human reproduction, 10 12
J. Banchereau, R. Steinman (1998)
Dendritic cells and the control of immunityNature, 392
P. Cravens, P. Lipsky (2002)
Dendritic cells, chemokine receptors and autoimmune inflammatory diseasesImmunology and Cell Biology, 80
N. Johnson, S. Bhattu, A. Wagner, D. Blake, L. Chamley (2005)
Lipiodol alters murine uterine dendritic cell populations: a potential mechanism for the fertility-enhancing effect of lipiodol.Fertility and sterility, 83 6
J. Halme, M. Hammond, J. Hulka, S. Raj, L. Talbert (1984)
Retrograde menstruation in healthy women and in patients with endometriosis.Obstetrics and gynecology, 64 2
J. Sampson
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavityAmerican Journal of Obstetrics and Gynecology, 14
Y. Na, Jun-O Jin, Mi-Sook Lee, M. Song, Kyu‐Sup Lee, J. Kwak (2008)
Peritoneal fluid from endometriosis patients switches differentiation of monocytes from dendritic cells to macrophages.Journal of reproductive immunology, 77 1
D. Vinatier, P. Dufour, D. Oosterlynck (1996)
Immunological aspects of endometriosis.Human reproduction update, 2 5
Z. ULC̆OVÁ‐GALLOVÁ, V. Bouse, L. Svábek, J. Turek, Z. Rokyta (2002)
Endometriosis in Reproductive ImmunologyAmerican Journal of Reproductive Immunology, 47
J. Crispín, J. Alcocer-Varela (2007)
The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus.Autoimmunity reviews, 6 7
P. Viganò, F. Parazzini, E. Somigliana, P. Vercellini (2004)
Endometriosis: epidemiology and aetiological factors.Best practice & research. Clinical obstetrics & gynaecology, 18 2
BACKGROUNDImmune alterations may be involved in the pathogenesis and progression of endometriosis. Dendritic cells (DCs) are potent antigen presenting cells that are highly involved in the initiation of the immune response. The aim of this study was to investigate DC populations in the eutopic and ectopic endometrium of women with endometriosis compared with controls.METHODSHysterectomy samples were obtained from premenopausal women with (n 33) and without (n 28) endometriosis. In addition, paired peritoneal endometriotic lesions and uterine curettings were collected from 32 women with endometriosis. Specimen sections were stained immunohistochemically using antibodies for monoclonal mouse antibodies directed against human CD1a and CD83, which are specific for immature and mature DCs, respectively.RESULTSThe mean density of endometrial CD1a DCs in the basal layer was significantly increased in women with endometriosis compared with controls during the proliferative phase only (P 0.001). There was a highly significant decrease in the density of endometrial CD83 DCs in women with endometriosis compared with controls in both layers of the endometrium across all phases of the menstrual cycle (P 0.001). The density of CD1a DCs was significantly increased in peritoneal endometriotic lesions (P 0.003) and in the surrounding peritoneum (P 0.001) compared with paired uterine curettings and peritoneum distant from the lesion.CONCLUSIONSBoth CD1a and CD83 DC populations were altered in the eutopic and ectopic endometrium of women with endometriosis compared with controls. Alterations in these cells, which play a crucial role in the coordination of the immune response, may be involved in pain generation and the pathogenesis of endometriosis.
Human Reproduction – Oxford University Press
Published: Jul 24, 2009
Keywords: endometriosis endometrium menstrual cycle dendritic cells peritoneal lesions
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