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Cut-off Hematocrit Value for Hemoconcentration in Dengue Hemorrhagic Fever

Downloaded from tropej.oxfordjournals.org at Infovell on December 15, 2010 be lower in the preschool age group, thus necessitating a separate cut-off for this age group. As per the definition of hemoconcentration, the mean in the control population plus 20 per cent of the mean was considered as a cut-off. These values were: ≥38.42 (94th percentile) in those <5 years, and ≥42.32 (99th percentile) in those >5 years. This cut-off obtained from the control population had a sensitivity and specificity of 49 per cent and 94 per cent, respectively in <5 years, and 54 per cent and 99 per cent, respectively in >5 years in predicting hemoconcentration. Using the population mean (sample mean ± 1.96 SE) a similar sensitivity and specificity pattern emerged without altering the end results. Different percentiles of control population were applied to the study group and analysed using the principle of receiver operator curve (ROC). The hematocrit value corresponding to the 72.5th percentile for both the age groups (≥34.8 per cent in <5 years and ≥37.5 per cent in >5 years) had a sensitivity and specificity of 71 and 74 per cent, and 76 and 73 per cent, respectively, in predicting hemoconcentration (Table 2). TABLE http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Tropical Pediatrics Oxford University Press

Cut-off Hematocrit Value for Hemoconcentration in Dengue Hemorrhagic Fever

Abstract

Downloaded from tropej.oxfordjournals.org at Infovell on December 15, 2010 be lower in the preschool age group, thus necessitating a separate cut-off for this age group. As per the definition of hemoconcentration, the mean in the control population plus 20 per cent of the mean was considered as a cut-off. These values were: ≥38.42 (94th percentile) in those <5 years, and ≥42.32 (99th percentile) in those >5 years. This cut-off obtained from the control population had a sensitivity and specificity of 49 per cent and 94 per cent, respectively in <5 years, and 54 per cent and 99 per cent, respectively in >5 years in predicting hemoconcentration. Using the population mean (sample mean ± 1.96 SE) a similar sensitivity and specificity pattern emerged without altering the end results. Different percentiles of control population were applied to the study group and analysed using the principle of receiver operator curve (ROC). The hematocrit value corresponding to the 72.5th percentile for both the age groups (≥34.8 per cent in <5 years and ≥37.5 per cent in >5 years) had a sensitivity and specificity of 71 and 74 per cent, and 76 and 73 per cent, respectively, in predicting hemoconcentration (Table 2). TABLE
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