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Critical limitations in biological production of chemicals: process or genetic solutions?

Critical limitations in biological production of chemicals: process or genetic solutions? AbstractProduction of bulk chemicals by biological processes is presently limited by failure of contemporary biological and bioreactor technology to deliver high product concentrations in high space-time yields in fluids of sufficiently low water content for subsequent down-stream processing operations. Limitations in the bioreactor portion of the process can arise due to failure to process sufficient substrate, substrate inhibition, inadequate rates or yields, and product inhibition. Various process approaches for addressing many of these limitations have been demonstrated or conceptualized. Less developed but potentially effective are genetic strategies addressing these process limitations. Ideally, the most effective combination of genetic and process approaches should be integrated in a synergistic fashion to maximize the economic potential of biological production of chemicals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png FEMS Microbiology Reviews Oxford University Press

Critical limitations in biological production of chemicals: process or genetic solutions?

FEMS Microbiology Reviews , Volume 16 (2-3) – Feb 1, 1995

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References (8)

Publisher
Oxford University Press
Copyright
© 1995 Federation of European Microbiological Societies
ISSN
0168-6445
eISSN
1574-6976
DOI
10.1111/j.1574-6976.1995.tb00174.x
Publisher site
See Article on Publisher Site

Abstract

AbstractProduction of bulk chemicals by biological processes is presently limited by failure of contemporary biological and bioreactor technology to deliver high product concentrations in high space-time yields in fluids of sufficiently low water content for subsequent down-stream processing operations. Limitations in the bioreactor portion of the process can arise due to failure to process sufficient substrate, substrate inhibition, inadequate rates or yields, and product inhibition. Various process approaches for addressing many of these limitations have been demonstrated or conceptualized. Less developed but potentially effective are genetic strategies addressing these process limitations. Ideally, the most effective combination of genetic and process approaches should be integrated in a synergistic fashion to maximize the economic potential of biological production of chemicals.

Journal

FEMS Microbiology ReviewsOxford University Press

Published: Feb 1, 1995

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