Commentary. Interaction of dietary antioxidants in vivo : how fruit and vegetables prevent disease?

Commentary. Interaction of dietary antioxidants in vivo : how fruit and vegetables prevent disease? Epidemiological studies indicate that fruit and vegetables are health-promoting and protective against disease, particularly cardiovascular disease and cancer. Possible plant nutrients providing this protection include antioxidants and dietary fibre. Clinical trials with antioxidant supplements give inconsistent results for protection against lung cancer in smokers, invasive cervical cancer, oesophageal and gastric cancers, colorectal polyps and coronary heart disease. The antioxidants used in trials may be contributing to a more complex system. Antioxidants have differing solubilities which partition across the phases of tissues, cells and macromolecular structures: water-soluble ascorbate, glutathione and urate; lipid-soluble tocopherols ane carotenoids, and intermediatory-soluble flavonoids and hydroxycinnamic acids. The health protection provided by fruit and vegetables could arise through an integrated reductive environment delivered by plant antioxidants of differing solubility in each of the tissue, cellular and macromolecular phases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png QJM: An International Journal of Medicine Oxford University Press

Commentary. Interaction of dietary antioxidants in vivo : how fruit and vegetables prevent disease?

Commentary. Interaction of dietary antioxidants in vivo : how fruit and vegetables prevent disease?


Q J Med 1999; 92:527­530 Commentary QJM Interaction of dietary antioxidants in vivo: how fruit and vegetables prevent disease? M.A. EASTWOOD From the Gastrointestinal Unit, Department of Medicine, University of Edinburgh, Western General Hospital Trust, Edinburgh, UK Summary Epidemiological studies indicate that fruit and vegetables are health-promoting and protective against disease, particularly cardiovascular disease and cancer. Possible plant nutrients providing this protection include antioxidants and dietary fibre. Clinical trials with antioxidant supplements give inconsistent results for protection against lung cancer in smokers, invasive cervical cancer, oesophageal and gastric cancers, colorectal polyps and coronary heart disease. The antioxidants used in trials may be contributing to a more complex system. Antioxidants have differing solubilities which partition across the phases of tissues, cells and macromolecular structures: water-soluble ascorbate, glutathione and urate; lipid-soluble tocopherols and carotenoids, and intermediatorysoluble flavonoids and hydroxycinnamic acids. The health protection provided by fruit and vegetables could arise through an integrated reductive environment delivered by plant antioxidants of differing solubility in each of the tissue, cellular and macromolecular phases. Introduction Diets which contain an abundance of fruit and vegetables are protective against a variety of diseases, particularly cardiovascular disease and epithelial (but not hormone-related) cancers. The principle nutrients thought to provide the protection afforded by fruit and vegetables are the antioxidants1 and dietary fibre (non-starch polysaccharides2). In trying to unravel the underlying mechanisms of this protection, various approaches have been taken. Epidemiological studies usually start with a measurement of dietary intake or serum concentrations of the studied antioxidant. Human supplementation trials are critical to testing any...
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Publisher
Oxford University Press
Copyright
Copyright 1999
ISSN
1460-2725
eISSN
1460-2393
D.O.I.
10.1093/qjmed/92.9.527
Publisher site
See Article on Publisher Site

Abstract

Epidemiological studies indicate that fruit and vegetables are health-promoting and protective against disease, particularly cardiovascular disease and cancer. Possible plant nutrients providing this protection include antioxidants and dietary fibre. Clinical trials with antioxidant supplements give inconsistent results for protection against lung cancer in smokers, invasive cervical cancer, oesophageal and gastric cancers, colorectal polyps and coronary heart disease. The antioxidants used in trials may be contributing to a more complex system. Antioxidants have differing solubilities which partition across the phases of tissues, cells and macromolecular structures: water-soluble ascorbate, glutathione and urate; lipid-soluble tocopherols ane carotenoids, and intermediatory-soluble flavonoids and hydroxycinnamic acids. The health protection provided by fruit and vegetables could arise through an integrated reductive environment delivered by plant antioxidants of differing solubility in each of the tissue, cellular and macromolecular phases.

Journal

QJM: An International Journal of MedicineOxford University Press

Published: Sep 1, 1999

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