Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates

Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates TOTHE EDITOR—Infections caused by New Delhi metallo-β lactamase 1 (NDM-1)– producing Enterobacteriaceae are reported to have a significantly higher likelihood of in-hospital mortality [1]. Previous evidence CORRESPONDENCE � CID 2016:63 (15 November) � 1393 showed that NDM-producing bacteria with neonatal sepsis and treated with levo- sequence typing indicated that EC1002 are often susceptible to colistin, which floxacin and amoxicillin-clavulanic acid. belonged to sequence type (ST) 2373 has become the last resort for the Patient 2 was a 56-year-old man who suf- and EC2474 was ST131. Polymerase treatment of infections due to NDM- fered a traffic accident and was admitted to chain reaction and sequencing identified producing bacteria [2]. However, the the Anhui Provincial Hospital, China. An both isolates encoding the MCR-1, plasmid-mediated colistin resistance E. coli strain EC2474 was recovered from bla ,and bla genes. EC1002 NDM-1 CTX-M-15 (MCR-1) gene, was first identified in En- the blood culture. Both patients showed also positive for aac(6′)-Ib and bla , TEM-1 terobacteriaceae recently [3]. Therefore, clinical improvement after antibiotic thera- and EC2474 was positive for bla CTX-M-55 patients ultimately might receive only ex- py and were discharged after lengthy hospi- and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Infectious Diseases Oxford University Press

Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates

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Publisher
Oxford University Press
Copyright
The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com
ISSN
1058-4838
eISSN
1537-6591
DOI
10.1093/cid/ciw553
Publisher site
See Article on Publisher Site

Abstract

Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates TOTHE EDITOR—Infections caused by New Delhi metallo-β lactamase 1 (NDM-1)– producing Enterobacteriaceae are reported to have a significantly higher likelihood of in-hospital mortality [1]. Previous evidence CORRESPONDENCE � CID 2016:63 (15 November) � 1393 showed that NDM-producing bacteria with neonatal sepsis and treated with levo- sequence typing indicated that EC1002 are often susceptible to colistin, which floxacin and amoxicillin-clavulanic acid. belonged to sequence type (ST) 2373 has become the last resort for the Patient 2 was a 56-year-old man who suf- and EC2474 was ST131. Polymerase treatment of infections due to NDM- fered a traffic accident and was admitted to chain reaction and sequencing identified producing bacteria [2]. However, the the Anhui Provincial Hospital, China. An both isolates encoding the MCR-1, plasmid-mediated colistin resistance E. coli strain EC2474 was recovered from bla ,and bla genes. EC1002 NDM-1 CTX-M-15 (MCR-1) gene, was first identified in En- the blood culture. Both patients showed also positive for aac(6′)-Ib and bla , TEM-1 terobacteriaceae recently [3]. Therefore, clinical improvement after antibiotic thera- and EC2474 was positive for bla CTX-M-55 patients ultimately might receive only ex- py and were discharged after lengthy hospi- and

Journal

Clinical Infectious DiseasesOxford University Press

Published: Nov 15, 2016

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