Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates TOTHE EDITOR—Infections caused by New Delhi metallo-β lactamase 1 (NDM-1)– producing Enterobacteriaceae are reported to have a signiﬁcantly higher likelihood of in-hospital mortality . Previous evidence CORRESPONDENCE � CID 2016:63 (15 November) � 1393 showed that NDM-producing bacteria with neonatal sepsis and treated with levo- sequence typing indicated that EC1002 are often susceptible to colistin, which ﬂoxacin and amoxicillin-clavulanic acid. belonged to sequence type (ST) 2373 has become the last resort for the Patient 2 was a 56-year-old man who suf- and EC2474 was ST131. Polymerase treatment of infections due to NDM- fered a trafﬁc accident and was admitted to chain reaction and sequencing identiﬁed producing bacteria . However, the the Anhui Provincial Hospital, China. An both isolates encoding the MCR-1, plasmid-mediated colistin resistance E. coli strain EC2474 was recovered from bla ,and bla genes. EC1002 NDM-1 CTX-M-15 (MCR-1) gene, was ﬁrst identiﬁed in En- the blood culture. Both patients showed also positive for aac(6′)-Ib and bla , TEM-1 terobacteriaceae recently . Therefore, clinical improvement after antibiotic thera- and EC2474 was positive for bla CTX-M-55 patients ultimately might receive only ex- py and were discharged after lengthy hospi- and
Clinical Infectious Diseases – Oxford University Press
Published: Nov 15, 2016
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