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Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling

Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone... Downloaded from https://academic.oup.com/jcem/article-abstract/69/3/523/2653310 by Ed 'DeepDyve' Gillespie user on 15 October 2019 0021-972X/89/6903-0523$02.00/0 Journal of Clinical Endocrinology and Metabolism Vol. 69, No. 3 Copyright © 1989 by The Endocrine Society Printed in U.S.A. Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling* JAN J. STEPAN, MILOS LACHMAN, JAN ZVERINA, VLADIMIR PACOVSKY, AND DAVID J. BAYLINK Department of Medicine 3, Charles University Faculty of Medicine, Prague, Czechoslovakia; and Loma Linda University, Jerry L. Pettis Veterans Hospital, Loma Linda, California 92357 ABSTRACT. To test the hypothesis that the reduction in and percent change in spinal bone mineral density per yr. gonadal function can lead to bone mass loss, a group of 12 men Because of this increase in the biochemically indicated bone who had undergone bilateral orchidectomy at the age of 28.2 ± resorption, nine of the patients were studied again after 1-3 yr and were thereafter treated with intranasal calcitonin. Urinary 6.8 yr was evaluated. A progressive loss of the lumbar bone hydroxyproline excretion normalized after 3 months of treat- density was observed as a function of time after orchidectomy. ment, and a significant decrease, but not to normal levels, was Both the biochemical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling

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References (22)

Publisher
Oxford University Press
Copyright
Copyright © 1989 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-69-3-523
Publisher site
See Article on Publisher Site

Abstract

Downloaded from https://academic.oup.com/jcem/article-abstract/69/3/523/2653310 by Ed 'DeepDyve' Gillespie user on 15 October 2019 0021-972X/89/6903-0523$02.00/0 Journal of Clinical Endocrinology and Metabolism Vol. 69, No. 3 Copyright © 1989 by The Endocrine Society Printed in U.S.A. Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling* JAN J. STEPAN, MILOS LACHMAN, JAN ZVERINA, VLADIMIR PACOVSKY, AND DAVID J. BAYLINK Department of Medicine 3, Charles University Faculty of Medicine, Prague, Czechoslovakia; and Loma Linda University, Jerry L. Pettis Veterans Hospital, Loma Linda, California 92357 ABSTRACT. To test the hypothesis that the reduction in and percent change in spinal bone mineral density per yr. gonadal function can lead to bone mass loss, a group of 12 men Because of this increase in the biochemically indicated bone who had undergone bilateral orchidectomy at the age of 28.2 ± resorption, nine of the patients were studied again after 1-3 yr and were thereafter treated with intranasal calcitonin. Urinary 6.8 yr was evaluated. A progressive loss of the lumbar bone hydroxyproline excretion normalized after 3 months of treat- density was observed as a function of time after orchidectomy. ment, and a significant decrease, but not to normal levels, was Both the biochemical

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Sep 1, 1989

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