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In most studies, body mass index (BMI) has been associated with increased risk of colorectal or colon cancer in men, but the relation is weaker and less consistent for women, possibly because of interactions with age or hormone replacement therapy. The authors examined the relation between BMI and colorectal cancer incidence in a large, prospective US cohort of 307,708 men and 209,436 women from the NIHAARP Diet and Health Study. During follow-up of the cohort from 1995 to 2000, 2,314 cases of colorectal cancer were observed in men and 1,029 in women. BMI was related to increased risk of incident colon cancer, but not rectal cancer, for both men and women. For men, relative risks of colon cancer for a BMI of 18.5<23, 23<25, 25<27.5, 27.5<30, 30<32.5, 32.5<35, 35<40, and 40 kg/m2 were 1.0 (referent), 1.11, 1.22, 1.44, 1.53, 1.57, 1.71, and 2.39, respectively (95% confidence interval: 1.59, 3.58; p-trend < 0.0005). Corresponding relative risks for women were 1.0, 1.20, 1.29, 1.31, 1.28, 1.13, 1.46, and 1.49 (95% confidence interval: 0.98, 2.25; p-trend 0.02). BMI was related to colon cancer risk for younger (aged 5066 years) but not older (aged 6771 years) women. The association was not modified by hormone replacement therapy in women or physical activity in men or women.
American Journal of Epidemiology – Oxford University Press
Published: Apr 21, 2007
Keywords: body mass index colonic neoplasms colorectal neoplasms humans obesity overweight rectal neoplasms
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