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(TsuyuguchiT Techniques of biliary drainage for acute cholecystitis: Tokyo Guidelines J Hepatobiliary Pancreat Surg (2007) 14:46–51)
TsuyuguchiT Techniques of biliary drainage for acute cholecystitis: Tokyo Guidelines J Hepatobiliary Pancreat Surg (2007) 14:46–51TsuyuguchiT Techniques of biliary drainage for acute cholecystitis: Tokyo Guidelines J Hepatobiliary Pancreat Surg (2007) 14:46–51, TsuyuguchiT Techniques of biliary drainage for acute cholecystitis: Tokyo Guidelines J Hepatobiliary Pancreat Surg (2007) 14:46–51
(BariePSEachempatiSR Acute acalculous cholecystitis. Curr Gastroenterol Rep. 2003 Aug;5(4):302–912864960)
BariePSEachempatiSR Acute acalculous cholecystitis. Curr Gastroenterol Rep. 2003 Aug;5(4):302–912864960BariePSEachempatiSR Acute acalculous cholecystitis. Curr Gastroenterol Rep. 2003 Aug;5(4):302–912864960, BariePSEachempatiSR Acute acalculous cholecystitis. Curr Gastroenterol Rep. 2003 Aug;5(4):302–912864960
(GorschlüterM Cholecystitis in neutropenic patients: Retrospective study and systematic review. Leukemia Research 30 (2006) 521–52816483649)
GorschlüterM Cholecystitis in neutropenic patients: Retrospective study and systematic review. Leukemia Research 30 (2006) 521–52816483649GorschlüterM Cholecystitis in neutropenic patients: Retrospective study and systematic review. Leukemia Research 30 (2006) 521–52816483649, GorschlüterM Cholecystitis in neutropenic patients: Retrospective study and systematic review. Leukemia Research 30 (2006) 521–52816483649
M. Gorschlüter, U. Mey, J. Strehl, M. Schepke, C. Lamberti, T. Sauerbruch, A. Glasmacher (2006)
Cholecystitis in neutropenic patients: retrospective study and systematic review.Leukemia research, 30 5
S. Beardsley, R. Shlansky-Goldberg, Aalpen Patel, D. Freiman, M. Soulen, S. Stavropoulos, T. Clark (2005)
Predicting Infected Bile Among Patients Undergoing Percutaneous CholecystostomyCardioVascular and Interventional Radiology, 28
E. Silberfein, W. Zhou, P. Kougias, Hosam Sayed, T. Huynh, D. Albo, D. Berger, F. Brunicardi, P. Lin (2007)
Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program.American journal of surgery, 194 5
T. Tsuyuguchi, T. Takada, Y. Kawarada, Y. Nimura, K. Wada, M. Nagino, T. Mayumi, Masahiro Yoshida, F. Miura, A. Tanaka, Y. Yamashita, M. Hirota, K. Hirata, H. Yasuda, Y. Kimura, H. Neuhaus, S. Strasberg, H. Pitt, J. Belghiti, G. Belli, J. Windsor, Miin‐Fu Chen, Sun-Whe Kim, C. Dervenis (2007)
Techniques of biliary drainage for acute cholecystitis: Tokyo GuidelinesJournal of Hepato-Biliary-Pancreatic Surgery, 14
P. Barie, Soumitra Eachempati (2010)
Acute acalculous cholecystitis.Gastroenterology clinics of North America, 39 2
(BeardsleySL Predicting Infected Bile among patients undergoing percutaneous cholecystostomy. Cardiovasc Intervent Radiol (2005) 28:319–32515886948)
BeardsleySL Predicting Infected Bile among patients undergoing percutaneous cholecystostomy. Cardiovasc Intervent Radiol (2005) 28:319–32515886948BeardsleySL Predicting Infected Bile among patients undergoing percutaneous cholecystostomy. Cardiovasc Intervent Radiol (2005) 28:319–32515886948, BeardsleySL Predicting Infected Bile among patients undergoing percutaneous cholecystostomy. Cardiovasc Intervent Radiol (2005) 28:319–32515886948
(HatzidakisAA Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol (2002) 12(7):1778–8412111069)
HatzidakisAA Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol (2002) 12(7):1778–8412111069HatzidakisAA Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol (2002) 12(7):1778–8412111069, HatzidakisAA Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol (2002) 12(7):1778–8412111069
(SilberfeinEJ Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery 194 (2007) 672–677)
SilberfeinEJ Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery 194 (2007) 672–677SilberfeinEJ Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery 194 (2007) 672–677, SilberfeinEJ Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery 194 (2007) 672–677
(SpiraRMNissanAZamirOCohenTFieldsSIFreundHR Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute calculus cholecystitis. The American Journal of Surgery 183 (2002) 62–66)
SpiraRMNissanAZamirOCohenTFieldsSIFreundHR Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute calculus cholecystitis. The American Journal of Surgery 183 (2002) 62–66SpiraRMNissanAZamirOCohenTFieldsSIFreundHR Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute calculus cholecystitis. The American Journal of Surgery 183 (2002) 62–66, SpiraRMNissanAZamirOCohenTFieldsSIFreundHR Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute calculus cholecystitis. The American Journal of Surgery 183 (2002) 62–66
R. Spira, A. Nissan, O. Zamir, T. Cohen, S. Fields, H. Freund (2002)
Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute calculus cholecystitis.American journal of surgery, 183 1
A. Hatzidakis, P. Prassopoulos, I. Petinarakis, E. Sanidas, E. Chrysos, G. Chalkiadakis, D. Tsiftsis, N. Gourtsoyiannis (2002)
Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatmentEuropean Radiology, 12
JSCR Journal of Surgical Case Reports http://jscr.co.uk Alithiasic cholecystitis treated by percutaneous cholecystostomy in a patient with severe septic shock and neutropenia Authors: N Simion Location: Riviera Hospital, Montreux, Switzerland Citation: Simion N. Alithiasic cholecystitis treated by percutaneous cholecystostomy in a patient with severe septic shock and neutropenia. JSCR 2012. 2:4 ABSTRACT Acalculous cholecystitis is a relatively rare form of cholecystitis appearing in severely ill patients. We chose the case of a young patient under chemotherapy for myeloid leukaemia who developed a severe septic shock secondary to an alithiasic cholecystitis. Because of hemodynamic instability needing high-dose of vasoactive amines, percutaneous gallbladder drainage was done. After this intervention, the septic shock could be controlled, but a bleeding liver laceration was observed, fortunately without morbidity consequences. Abdominal infections are life-threatening complications in neutropenic patients. Neutropenic enterocolitis is the most important entity, but the acute cholecystitis, even rarer, had been described in several reports, suggesting that this infection could represent a difficult trap. INTRODUCTION Patients with leukaemia undergoing aggressive chemotherapy are often affected by abdominal infections becoming life-threatening conditions. It is a diagnostic challenge for the physician to detect the cause of abdominal symptoms (infectious and non-infectious) in these patients (1,2). Acalculous cholecystitis is a form of acute cholecystitis seen more frequently in immunosuppressed and high risk patients. The treatment of choice for acute cholecystitis is surgical, but in selected cases conservative treatment followed by elective cholecystectomy later or cholecystostomy could represent an alternative (2,3). CASE REPORT We report the case of a 36-year-old man with the diagnosis of acute myeloid leukemia type M4 (>90% blasts). The patient was treated firstly by cytoreduction chemotherapy followed by induction chemotherapy (cytarabine + idarubicine). During this period the patient was admitted in hospital with diarrhoea and febrile agranulocytosis. Neutropenic colitis was diagnosed and confirmed by CT scan, the patient being treated with broad spectrum antibiotics leading to a good recovery. page 1 / 3 JSCR Journal of Surgical Case Reports http://jscr.co.uk One month later the first consolidation chemotherapy (cytarabine + amsacrine) was done and 6 days afterwards the patient presented diarrhoea without abdominal pain or fever. The laboratory investigations revealed a total leukocyte 3 3 count of 500/mm , a haemoglobin level of 68 g/L and a platelet count of 11 000/mm . Despite supportive treatment and antibiotics for a supposed improving colitis, the patient complained of right upper quadrant abdominal pain, high fever (40°C) and hypotension needing ICU admission with the diagnose of abdominal sepsis. A positive Murphy’s sign was observed at physical abdominal examination. The radiological imaging was suggestive for an alithiasic cholecystitis, even though a transverse colon wall thickening was also seen in computed tomography. The patient was considered to unstable for a surgical intervention and an emergency percutaneous CT-guided cholecystostomy was done, in spite of a very low platelet count (7 000/mm ). 24 hours later, the septic shock rapidly improved, but hemoglobin level fell down from 83 to 61 g/L. A CT scan showed a bleeding liver laceration with intraperitoneal haemorrhage secondary to the transhepatic percutaneous gallbladder drainage. The patient was treated conservatively receiving several transfusions and went well without any further complications. DISCUSSION Alithiasic cholecystitis is an entity occurring typical in the elderly, severely ill and high risk patients typically hospitalised in the ICU. The frequency of acute cholecystitis between patients with myelosupressive chemotherapy and neutropenia is estimated at 0.4% in the literature, with a nearly 30% mortality. The majority of the neutropenic patients develop acalculous cholecystitis, in contrast with non-neutropenic patients to whom acalculous cholecystitis comprises only approximately 5% of all cases of acute cholecystitis (1). The clinical diagnosis of acute cholecystitis (AC) remains difficult in the patient population with multiple comorbid conditions, the typical signs and symptoms being easily masked among page 2 / 3 JSCR Journal of Surgical Case Reports http://jscr.co.uk ventilated, paralyzed or immunosuppressed patients. Ultrasound is an established valuable imaging method if cholecystitis is suspected and a thickened gallbladder wall greater than 3mm is considered typical for diagnosis. Other frequent sonographic findings are pericholecystic fluid and over-distension. Similar findings can be demonstrated by CT, computed tomography being extremely useful in the assessment of septic shock of unknown origin in this patient population (1,4). Laparoscopic cholecystectomy is widely considered as the treatment of choice for acute cholecystitis and it can be performed safely in selected patients. Surgery in patients with neutropenia, thrombopenia and sepsis who present with an acute abdomen is however associated with a high mortality. Percutaneous cholecystostomy (PC) was described as a minimally invasive, image-guided procedure and has become an alternative treatment strategy for high-risk patients with acute calculous or acalculous cholecystitis who are unfit for urgent surgery (1,5). Percutaneous cholecystostomy could be also used as a method of exclusion of the gallbladder/biliary tree as a source of sepsis in unstable severely ill patients. The positive response is defined as resolution of right upper quadrant abdominal pain and normalization of general clinical state, usually within 48 hours (4 ). The procedure can be performed CT-guided or US-guided, even at the bedside in the ICU. The safety of the procedure and its minimal invasiveness made it a valid treatment option for a patient not responding to antibiotic therapy or being in severe shock and unfit for immediate cholecystectomy. The results from several series prove that the percutaneous gallbladder drainage is safe and that it was effective in more than 85% of the patients. There were no bile duct injuries or any other major surgical complications in this group of patients (6,7). REFERENCES 1. Gorschlüter M et al. Cholecystitis in neutropenic patients: Retrospective study and systematic review. Leukemia Research 30 (2006) 521–528 2. Hatzidakis AA et al. Acute cholecystitis in high-risk patients: percutaneous cholecystostomy vs conservative treatment. Eur Radiol (2002) 12(7):1778-84 3. Tsuyuguchi T. Techniques of biliary drainage for acute cholecystitis: Tokyo Guidelines J Hepatobiliary Pancreat Surg (2007) 14:46–51 4. Beardsley SL et al. Predicting Infected Bile among patients undergoing percutaneous cholecystostomy. Cardiovasc Intervent Radiol (2005) 28:319–325 5. Silberfein EJ et al. Percutaneous cholecystostomy for acute cholecystitis in high-risk patients: experience of a surgeon-initiated interventional program. The American Journal of Surgery 194 (2007) 672–677 6. Spira RM, Nissan A, Zamir O, Cohen T, Fields SI, Freund HR. Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute calculus cholecystitis. The American Journal of Surgery 183 (2002) 62–66 7. Barie PS, Eachempati SR Acute acalculous cholecystitis. Curr Gastroenterol Rep. 2003 Aug;5(4):302-9 page 3 / 3 Powered by TCPDF (www.tcpdf.org)
Journal of Surgical Case Reports – Oxford University Press
Published: Feb 1, 2012
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