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Age-Related Change in the Twenty-Four Hour Spontaneous Secretion of Growth Hormone

Age-Related Change in the Twenty-Four Hour Spontaneous Secretion of Growth Hormone ABSTRACT Spontaneous growth hormone secretion rates and secretory patterns were studied in a group of normal prepubertal children, adolescents and young and older adults by determining the concentration of growth hormone in plasma samples obtained at 20-min intervals over a 24-hr period. Prepubertal children secreted growth hormone only during sleep and not while awake and had a mean secretion rate of 91 μg/24 hr (range 54–122 μg/24 hr). Mean duration of secretion was 110 min/24 hr (range 60–180 min/24 hr). Adolescents secreted growth hormone during both awake and sleep periods and had a mean secretion rate of 690 μg/24 hr (range 391–1406 μg/24 hr). Mean duration of secretion was 226 min/24 hr (range 100–300 min/24 hr). Secretion rates in young adults (21–41 yr) averaged 385 μg/24 hr (range 215–769 μg/24 hr). Average duration of secretion was 133 min/24 hr (range 100–300 min/24 hr). Growth hormone was secreted during both awake and asleep periods but the number of secretory episodes was less than in adolescents. In older adults (42–62 yr) the total 24-hr secretion of growth hormone decreased and approached zero in three of five studies. These data clearly demonstrate an age related change in the spontaneous secretory rate and secretory pattern of growth hormone. This content is only available as a PDF. Author notes Supported by Grants from The National Cancer Institute (Grant CA 07304), The National Institute of Mental Health (Grants 2-K5-MH-18,739 and MH 13269) and RR-53 from the General Research Centers Branch of the National Institute of Health and the American Cancer Society. Copyright © 1972 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Age-Related Change in the Twenty-Four Hour Spontaneous Secretion of Growth Hormone

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Publisher
Oxford University Press
Copyright
Copyright © 1972 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-35-5-665
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Spontaneous growth hormone secretion rates and secretory patterns were studied in a group of normal prepubertal children, adolescents and young and older adults by determining the concentration of growth hormone in plasma samples obtained at 20-min intervals over a 24-hr period. Prepubertal children secreted growth hormone only during sleep and not while awake and had a mean secretion rate of 91 μg/24 hr (range 54–122 μg/24 hr). Mean duration of secretion was 110 min/24 hr (range 60–180 min/24 hr). Adolescents secreted growth hormone during both awake and sleep periods and had a mean secretion rate of 690 μg/24 hr (range 391–1406 μg/24 hr). Mean duration of secretion was 226 min/24 hr (range 100–300 min/24 hr). Secretion rates in young adults (21–41 yr) averaged 385 μg/24 hr (range 215–769 μg/24 hr). Average duration of secretion was 133 min/24 hr (range 100–300 min/24 hr). Growth hormone was secreted during both awake and asleep periods but the number of secretory episodes was less than in adolescents. In older adults (42–62 yr) the total 24-hr secretion of growth hormone decreased and approached zero in three of five studies. These data clearly demonstrate an age related change in the spontaneous secretory rate and secretory pattern of growth hormone. This content is only available as a PDF. Author notes Supported by Grants from The National Cancer Institute (Grant CA 07304), The National Institute of Mental Health (Grants 2-K5-MH-18,739 and MH 13269) and RR-53 from the General Research Centers Branch of the National Institute of Health and the American Cancer Society. Copyright © 1972 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Nov 1, 1972

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