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S. Saitoh, R. Arudchandran, T. Manetz, W. Zhang, C. Sommers, P. Love, J. Rivera, L. Samelson (2000)
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.Immunity, 12 5
L. Liao, D. Granger (1996)
Role of mast cells in oxidized low-density lipoprotein-induced microvascular dysfunction.The American journal of physiology, 271 5 Pt 2
K. Sayama, M. Diehn, K. Matsuda, Carolina Lunderius, M. Tsai, S. Tam, D. Botstein, P. Brown, S. Galli (2002)
Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11BMC Immunology, 3
E. Prieschl, R. Csonga, V. Novotny, G. Kikuchi, T. Baumruker (1999)
The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I TriggeringThe Journal of Experimental Medicine, 190
E. Sheets, D. Holowka, B. Baird (1999)
Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant MembranesThe Journal of Cell Biology, 145
H. Niv, O. Gutman, Y. Kloog, Y. Henis (2002)
Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cellsThe Journal of Cell Biology, 157
M. Kaartinen, A. Wal, C. Loos, J. Piek, K. Koch, A. Becker, P. Kovanen (1998)
Mast cell infiltration in acute coronary syndromes: implications for plaque rupture.Journal of the American College of Cardiology, 32 3
S. Saitoh, R. Arudchandran, T. Manetz, Weiguo Zhang, C. Sommers, P. Love, J. Rivera, L. Samelson (2000)
LAT Is Essential for FcεRI-Mediated Mast Cell ActivationImmunity, 12
E. Preischl, G. Pendl, A. Elbe, E. Serfling, N. Harrer, G. Stingl, T. Baumruker (1996)
Induction of the TNF-alpha promoter in the murine dendritic cell line 18 and the murine mast cell line CPII is differently regulated.Journal of immunology, 157 6
R. Csonga, E. Prieschl, D. Jaksche, V. Novotny, T. Baumruker (1998)
Common and distinct signaling pathways mediate the induction of TNF-alpha and IL-5 in IgE plus antigen-stimulated mast cells.Journal of immunology, 160 1
Huaxian Chen, Michael Centola, S. Altschul, Henry Metzger (1998)
Characterization of Gene Expression in Resting and Activated Mast CellsThe Journal of Experimental Medicine, 188
Y. Nishiwaki, T. Takebayashi, K. Omae, C. Ishizuka, T. Nomiyama, H. Sakurai (2000)
Relationship between the blood coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population.Journal of epidemiology, 10 1
Activation of mast cells by cholesterol 1217
D. Tice, I. Soloviev, P. Polakis (2002)
Activation of the Wnt Pathway Interferes with Serum Response Element-driven Transcription of Immediate Early Genes*The Journal of Biological Chemistry, 277
E. Prieschl, V. Novotny, R. Csonga, D. Jaksche, A. Elbe-Bürger, W. Thumb, Manfred Auer, Georg Stingl, T. Baumruker (1998)
A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription.Nucleic acids research, 26 10
D. Scholz, H. Schmidt, E. Prieschl, R. Csonga, W. Scheirer, V. Weber, A. Lembachner, G. Seidl, G. Werner, P. Mayer, T. Baumruker (1998)
Inhibition of FcεRI-mediated activation of mast cells by 2,3,4-trihydropyrimidino[2,1-a]isoquinolinesJournal of Medicinal Chemistry, 41
R. Young, D. Holowka, B. Baird (2003)
A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation*Journal of Biological Chemistry, 278
B. Lesobre (1994)
[Cardiovascular risk factors in type 2 diabetes].Diabete & metabolisme, 20 3 Pt 2
D. Scholz, H. Schmidt, E. Prieschl, R. Csonga, W. Scheirer, V. Weber, A. Lembachner, G. Seidl, G. Werner, P. Mayer, T. Baumruker (1998)
Inhibition of Fc epsilon RI-mediated activation of mast cells by 2,3,4-trihydropyrimidino[2,1-a]isoquinolines.Journal of medicinal chemistry, 41 7
Anita Braccia, M. Villani, Lissi Immerdal, L. Niels-Christiansen, Birthe Nystrøm, Gert Hansen, E. Danielsen (2003)
Microvillar Membrane Microdomains Exist at Physiological TemperatureThe Journal of Biological Chemistry, 278
P. Constantinides (1995)
Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction.Circulation, 92 5
I. Prior, C. Muncke, R. Parton, J. Hancock (2003)
Direct visualization of Ras proteins in spatially distinct cell surface microdomainsThe Journal of Cell Biology, 160
S. Galli, J. Gordon, B. Wershil (1991)
Cytokine production by mast cells and basophilsCurrent Biology, 2
H. Metzger (1999)
It’s Spring, and Thoughts Turn to … AllergiesCell, 97
T. Baumruker, G. Pendl, E. Prieschl (1997)
Gene regulation after Fc epsilon RI stimulation in the murine mast cell line CPII.International archives of allergy and immunology, 113 1-3
D. Jarmin, P. Kulmburg, N. Huber, G. Baumann, E. Prieschl-Strassmayr, T. Baumruker (1994)
A transcription factor with AP3-like binding specificity mediates gene regulation after an allergic triggering with IgE and Ag in mouse mast cells.Journal of immunology, 153 12
H. Gaugitsch, E. Prieschl, F. Kalthoff, N. Huber, T. Baumruker (1992)
A novel transiently expressed, integral membrane protein linked to cell activation. Molecular cloning via the rapid degradation signal AUUUA.The Journal of biological chemistry, 267 16
Anita Braccia, M. Villani, Lissi Immerdal, L. Niels-Christiansen, B. Nystrøm, G. Hansen, E. Danielsen (2003)
Microvillar Membrane Microdomains Exist at Physiological Temperature ROLE OF GALECTIN-4 AS LIPID RAFT STABILIZER REVEALED BY “SUPERRAFTS”*
M. Jeziorska, Charles McCollum, D. Woolley (1997)
MAST CELL DISTRIBUTION, ACTIVATION, AND PHENOTYPE IN ATHEROSCLEROTIC LESIONS OF HUMAN CAROTID ARTERIESThe Journal of Pathology, 182
Arun Gidwani, D. Holowka, B. Baird (2001)
Fluorescence anisotropy measurements of lipid order in plasma membranes and lipid rafts from RBL-2H3 mast cells.Biochemistry, 40 41
P. Kulmburg, N. Huber, B. Scheer, M. Wrann, T. Baumruker (1992)
Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cellsThe Journal of Experimental Medicine, 176
E. Prieschl, R. Csonga, V. Novotny, G. Kikuchi, T. Baumruker (2000)
Glycosphingolipid-Induced Relocation of Lyn and Syk into Detergent-Resistant Membranes Results in Mast Cell ActivationThe Journal of Immunology, 164
Toshiharu Nakajima, Kenji Matsumoto, Hajime Suto, Kazuko Tanaka, M. Ebisawa, H. Tomita, K. Yuki, Toshio Katsunuma, A. Akasawa, R. Hashida, Y. Sugita, Hideoki Ogawa, Chisei Ra, Hirohisa Saito (2001)
Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: abundant expression of major basic protein in mast cells.Blood, 98 4
E. Chang, Y. Zheng, D. Holowka, B. Baird (1995)
Alteration of lipid composition modulates Fc epsilon RI signaling in RBL-2H3 cells.Biochemistry, 34 13
G. Pendl, E. Prieschl, W. Thumb, N. Harrer, M. Auer, T. Baumruker (1997)
Effects of phosphatidylinositol-3-kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells.International archives of allergy and immunology, 112 4
IgE plus antigen‐stimulated mast cells degranulate, synthesize leukotrienes and secrete cytokines. According to the coalescence model this process is initiated in specific membrane compartments termed rafts. There, enhanced levels of glycosphingolipids and cholesterol stabilize the interaction of FcϵRI and Lyn, and thus facilitate the first steps of signal transduction. Enforced changes in raft architecture by cholesterol deprivation and exogenous application of glycosphingolipids influence these early events by loss of tyrosine kinase activity or receptor‐independent signal initiation respectively. Here we show that exogenously added cholesterol accumulates in rafts and activates mast cells. An investigation of the signaling events reveals that in contrast to IgE plus antigen‐mediated stimulation, cholesterol triggers p38 mitogen‐activated protein kinase and preferentially induces expression of FosB. Consequently, a comparative large‐scale microarray analysis demonstrates that a number of IgE plus antigen‐induced immediate early genes (peak expression at 30 min after induction) are repressed by cholesterol. These changes further translate into altered expression levels and time kinetics of a number of early genes (peak expression at 2 h after stimulation). As the most prominent example for cholesterol‐dependent genes, we identified PAI1 (plasminogen activator inhibitor 1), a protein regarded as a risk factor for atherosclerosis.
International Immunology – Oxford University Press
Published: Oct 1, 2003
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