Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Muniz-Terrera, Annie Robitaille, Amanda Kelly, B. Johansson, S. Hofer, A. Piccinin (2017)
Latent growth models matched to research questions to answer questions about dynamics of change in multiple processes.Journal of clinical epidemiology, 82
(2015)
RStudio: Integrated development for R
M. Sliwinski, J. Mogle (2008)
Time-Based and Process-Based Approaches to Analysis of Longitudinal Data
R. Doty (2012)
Olfaction in Parkinson's disease and related disordersNeurobiology of Disease, 46
H. Braak, K. Tredici, U. Rüb, R. Vos, Ernst Steur, E. Braak (2003)
Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 24
R. Doty, P. Shaman, C. Kimmelman, M. Dann (1984)
University of pennsylvania smell identification test: A rapid quantitative olfactory function test for the clinicThe Laryngoscope, 94
Lesa Hoffman, R. Stawski (2009)
Persons as Contexts: Evaluating Between-Person and Within-Person Effects in Longitudinal AnalysisResearch in Human Development, 6
J. Attems, Lauren Walker, K. Jellinger (2014)
Olfactory bulb involvement in neurodegenerative diseasesActa Neuropathologica, 127
R. Wilson, J. Schneider, S. Arnold, Yuxiao Tang, P. Boyle, D. Bennett (2007)
Olfactory identification and incidence of mild cognitive impairment in older age.Archives of general psychiatry, 64 7
C. Schubert, M. Fischer, A. Pinto, B. Klein, R. Klein, T. Tweed, K. Cruickshanks, K. Cruickshanks (2016)
Sensory Impairments and Risk of Mortality in Older AdultsJournals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 72
M. Hedner, M. Larsson, N. Arnold, G. Zucco, T. Hummel (2010)
Cognitive factors in odor detection, odor discrimination, and odor identification tasksJournal of Clinical and Experimental Neuropsychology, 32
T. Kovács (2013)
The olfactory system in Alzheimer’s disease: Pathology, pathophysiology and pathway for therapyTranslational Neuroscience, 4
D. Bates, M. Machler, B. Bolker, Steven Walker (2014)
Fitting Linear Mixed-Effects Models Using lme4Journal of Statistical Software, 67
J. Lefcheck (2015)
piecewiseSEM: Piecewise structural equation modelling in r for ecology, evolution, and systematicsMethods in Ecology and Evolution, 7
D. Erten‐Lyons, R. Woltjer, H. Dodge, R. Nixon, R. Vorobik, James Calvert, M. Leahy, T. Montine, J. Kaye (2009)
Factors associated with resistance to dementia despite high Alzheimer disease pathologyNeurology, 72
H. Braak, E. Braak (2004)
Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 82
(2017)
PREVENT-AD Research Group
J. Seubert, J. Freiherr, J. Djordjevic, J. Lundström (2013)
Statistical localization of human olfactory cortexNeuroImage, 66
R. Wilson, L. Hebert, P. Scherr, L. Barnes, C. Leon, Denis Evans (2009)
Educational attainment and cognitive decline in old ageNeurology, 72
G. Ross, H. Petrovitch, R. Abbott, C. Tanner, J. Popper, K. Masaki, L. Launer, L. White (2008)
Association of olfactory dysfunction with risk for future Parkinson's diseaseAnnals of Neurology, 63
C. Schubert, Lakeesha Carmichael, C. Murphy, B. Klein, R. Klein, K. Cruickshanks (2008)
Olfaction and the 5‐Year Incidence of Cognitive Impairment in an Epidemiological Study of Older AdultsJournal of the American Geriatrics Society, 56
D. Devanand, Seonjoo Lee, J. Manly, H. Andrews, N. Schupf, R. Doty, Y. Stern, L. Zahodne, E. Louis, R. Mayeux (2015)
Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban communityNeurology, 84
R. Mesholam, P. Moberg, R. Mahr, R. Doty (1998)
Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases.Archives of neurology, 55 1
M. Jucker, L. Walker (2011)
Pathogenic protein seeding in alzheimer disease and other neurodegenerative disordersAnnals of Neurology, 70
J. Freiherr, A. Gordon, Eva Alden, Andrea Ponting, Monica Hernandez, S. Boesveldt, J. Lundström (2012)
The 40-item Monell Extended Sniffin’ Sticks Identification Test (MONEX-40)Journal of Neuroscience Methods, 205
I. Bennett, Shauna Stark, C. Stark (2019)
Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences
Marie-Élyse Lafaille-Magnan, J. Poirier, P. Étienne, J. Tremblay-Mercier, J. Frenette, P. Rosa-Neto, J. Breitner (2017)
Odor identification as a biomarker of preclinical AD in older adults at riskNeurology, 89
G. Shepherd (2007)
Perspectives on Olfactory Processing, Conscious Perception, and Orbitofrontal CortexAnnals of the New York Academy of Sciences, 1121
R. Doty, P. Reyes, T. Gregor (1987)
Presence of both odor identification and detection deficits in alzheimer's diseaseBrain Research Bulletin, 18
T. Kovács, N. Cairns, P. Lantos (2001)
Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stagesNeuroreport, 12
A. Piccinin, G. Muniz-Terrera, S. Clouston, C. Reynolds, Valgeir Thorvaldsson, I. Deary, D. Deeg, B. Johansson, A. Mackinnon, A. Spiro, J. Starr, I. Skoog, S. Hofer (2013)
Coordinated analysis of age, sex, and education effects on change in MMSE scores.The journals of gerontology. Series B, Psychological sciences and social sciences, 68 3
D. Roalf, Madelyn Moberg, B. Turetsky, L. Brennan, Sushila Kabadi, D. Wolk, P. Moberg (2016)
A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairmentJournal of Neurology, Neurosurgery & Psychiatry, 88
R. Wilson, Lei Yu, D. Bennett (2011)
Odor identification and mortality in old age.Chemical senses, 36 1
D. Lüdecke (2018)
Sjplot - Data Visualization For Statistics In Social Science.
A. Masurkar, D. Devanand (2014)
Olfactory Dysfunction in the Elderly: Basic Circuitry and Alterations with Normal Aging and Alzheimer’s DiseaseCurrent Geriatrics Reports, 3
R. Wilson, S. Arnold, J. Schneider, Yuxiao Tang, D. Bennett (2006)
The relationship between cerebral Alzheimer’s disease pathology and odour identification in old ageJournal of Neurology, Neurosurgery & Psychiatry, 78
(2009)
The locus ceruleus norepinephrine system: Functional organization and potential clinical significance
S. Rahayel, J. Frasnelli, S. Joubert (2012)
The effect of Alzheimer's disease and Parkinson's disease on olfaction: A meta-analysisBehavioural Brain Research, 231
H. Wickham (2009)
ggplot2 - Elegant Graphics for Data Analysis
D. Thal, U. Rüb, M. Orantes, H. Braak (2002)
Phases of Aβ-deposition in the human brain and its relevance for the development of ADNeurology, 58
J. Pinto, K. Wroblewski, David Kern, L. Schumm, M. McClintock, T. Hummel (2014)
Olfactory Dysfunction Predicts 5-Year Mortality in Older AdultsPLoS ONE, 9
G. Aston-Jones, J. Cohen (2005)
An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.Annual review of neuroscience, 28
A. Haehner, T. Hummel, C. Hummel, U. Sommer, S. Junghanns, H. Reichmann (2007)
Olfactory loss may be a first sign of idiopathic Parkinson's diseaseMovement Disorders, 22
R. Wilson, S. Arnold, J. Schneider, P. Boyle, A. Buchman, D. Bennett (2009)
Olfactory Impairment in Presymptomatic Alzheimer's DiseaseAnnals of the New York Academy of Sciences, 1170
R. Team (2014)
R: A language and environment for statistical computing.MSOR connections, 1
D. Bennett, J. Schneider, Z. Arvanitakis, J. Kelly, N. Aggarwal, R. Shah, R. Wilson (2006)
Neuropathology of older persons without cognitive impairment from two community-based studiesNeurology, 66
Lei Yu, M. Lutz, R. Wilson, D. Burns, A. Roses, A. Saunders, Jingyun Yang, Chris Gaiteri, P. Jager, L. Barnes, D. Bennett (2017)
APOE ε4-TOMM40 ‘523 haplotypes and the risk of Alzheimer’s disease in older Caucasian and African AmericansPLoS ONE, 12
Q. Tian, S. Resnick, S. Studenski (2016)
Olfaction Is Related to Motor Function in Older AdultsJournals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 72
M. Albers, M. Tabert, D. Devanand (2006)
Olfactory dysfunction as a predictor of neurodegenerative diseaseCurrent Neurology and Neuroscience Reports, 6
R. Doty, Avron Marcus, W. Lee (1996)
Development of the 12‐Item Cross‐Cultural Smell Identification Test(CC‐SIT)The Laryngoscope, 106
A. Serrano‐Pozo, M. Frosch, E. Masliah, B. Hyman (2011)
Neuropathological alterations in Alzheimer disease.Cold Spring Harbor perspectives in medicine, 1 1
Lesa Hoffman (2014)
Longitudinal Analysis: Modeling Within-Person Fluctuation and Change
D. Bennett, J. Schneider, A. Buchman, C. Leon, J. Bienias, R. Wilson (2005)
The Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study CohortNeuroepidemiology, 25
D. Devanand, Kristin Michaels-Marston, Xinhua Liu, G. Pelton, Margarita Padilla, K. Marder, K. Bell, Y. Stern, R. Mayeux (2000)
Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up.The American journal of psychiatry, 157 9
ObjectivesTo determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.MethodsWithin-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.ResultsIndividuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.DiscussionBSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology.
"The Journals of Gerontology - Series B: Psychological Sciences and Social Sciences" – Oxford University Press
Published: Feb 14, 2020
Keywords: Alzheimer’s disease; Cognition; Cognitive decline; Neurodegenerative; Smell
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.