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Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults

Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults ObjectivesTo determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.MethodsWithin-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.ResultsIndividuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.DiscussionBSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "The Journals of Gerontology - Series B: Psychological Sciences and Social Sciences" Oxford University Press

Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults

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References (54)

Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
ISSN
1079-5014
eISSN
1758-5368
DOI
10.1093/geronb/gby058
Publisher site
See Article on Publisher Site

Abstract

ObjectivesTo determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.MethodsWithin-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.ResultsIndividuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.DiscussionBSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology.

Journal

"The Journals of Gerontology - Series B: Psychological Sciences and Social Sciences"Oxford University Press

Published: Feb 14, 2020

Keywords: Alzheimer’s disease; Cognition; Cognitive decline; Neurodegenerative; Smell

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