Abstract Asthma is a heterogeneous disease, and responses to asthma medications vary noticeably among patients. A substantively oriented objective of this study was to explore the potential heterogeneous effects of maternal inhaled corticosteroids (ICS) exposure on gestational age (GA) at delivery and birthweight (BW) using a cohort of 6,197 pregnancies from women with asthma (Quebec, Canada, 1998-2008). A methodologically oriented objective was to comprehensively describe the application of a Bayesian two-component mixture of bivariate regressions to address this issue and estimate the effects of ICS on GA and BW jointly. Based on proposed model, no association between ICS and GA/BW was found for a large proportion of asthmatic pregnancies. However, a positive association between ICS exposure and GA/BW was revealed in a small subset of pregnancies mainly formed of preterm and low-birthweight infants. A novel application of this model was also subsequently performed using BW z-score instead of BW as outcome variable. In conclusion, the studied mixture of bivariate regressions was useful to detect heterogeneity of ICS effect on GA and BW in our population of women with asthma; these analyses pave the way for analogous uses of this model for general assessment of exposure effect heterogeneity for these perinatal outcomes. Asthma, inhaled corticosteroids, birthweight, gestational age, heterogeneity, mixture of regressions © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: email@example.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)
American Journal of Epidemiology – Oxford University Press
Published: May 14, 2018
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