SCIENCE TIMES 6. Gilard V, Djoubairou BO, Lepetit A, et al. progressed. In this study, the patient was reported. This response continued Small versus large catheters for ventriculostomy in the underwent surgical resection of 3 out of for 7.5 mo after initiation of CAR T-cell management of intraventricular hemorrhage. World 5 progressive tumors. A Rickham catheter therapy. However, the tumor eventually Neurosurg. 2017;97:117-122. was placed into the resection cavity of one recurred at 4 intracranial sites that were 7. Honeybul S, Ho KM, Gillett G. Outcome following decompressive hemicraniectomy for malignant of the tumors through which the patient different and non-adjacent to initial cerebral infarction: ethical considerations. Stroke. received 6 cycles of autologous CAR T- tumors. 2015;46(9):2695-2698. 6 3 cells (2–10 × 10 cells/infusion) that had The paper by Brown et al provides been modified to target the IL13Rα2. proof of concept for utilizing CAR T- The patient received 10 further doses cells in GBM. The route of delivery was Use of Chimeric Antigen through an intraventricular catheter after 2 shown to be important as intracavitary nonresected lesions continued to progress infusion appeared to act locally while Receptor T Cells as a and 2 new lesions appeared. Cerebrospinal intraventricular
Neurosurgery – Oxford University Press
Published: May 1, 2017
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