Understanding TB Transmission in the UK: Findings from Six Years of MIRU-VNTR Strain Typing, 2010 to 2015

Understanding TB Transmission in the UK: Findings from Six Years of MIRU-VNTR Strain Typing, 2010... Abstract Genotyping provides the opportunity to better understand tuberculosis (TB) transmission. We utilise strain typing data to assess trends in the proportion of clustering, and identify the characteristics of individuals and clusters associated with recent UK transmission. In this retrospective cohort analysis we included all culture-confirmed strain typed TB notifications from the UK between 2010 and 2015 to estimate the proportion of patients that clustered over time. We explored the characteristics of patients in a cluster using multivariable logistic regression. Overall, 58.5% of TB patients were in 2,701 clusters. The proportion of patients in a cluster decreased between 2010 (58.7%) and 2015 (55.3%) (P = 0.001). Being a clustered patient was associated with being male and UK born, having pulmonary disease, a previous TB diagnosis, and a history of drug misuse or imprisonment. Our results suggest TB transmission in the UK decreased between 2010 and 2015, during which time TB incidence also decreased. Targeted cluster investigation and extended contact tracing should be aimed at those at risk of being in a transmission chain, including UK born individuals with social risk factors in clusters with a high proportion of patients having pulmonary disease. Surveillance, Transmission, Tuberculosis, Genotyping © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Epidemiology Oxford University Press

Understanding TB Transmission in the UK: Findings from Six Years of MIRU-VNTR Strain Typing, 2010 to 2015

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Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
ISSN
0002-9262
eISSN
1476-6256
D.O.I.
10.1093/aje/kwy119
Publisher site
See Article on Publisher Site

Abstract

Abstract Genotyping provides the opportunity to better understand tuberculosis (TB) transmission. We utilise strain typing data to assess trends in the proportion of clustering, and identify the characteristics of individuals and clusters associated with recent UK transmission. In this retrospective cohort analysis we included all culture-confirmed strain typed TB notifications from the UK between 2010 and 2015 to estimate the proportion of patients that clustered over time. We explored the characteristics of patients in a cluster using multivariable logistic regression. Overall, 58.5% of TB patients were in 2,701 clusters. The proportion of patients in a cluster decreased between 2010 (58.7%) and 2015 (55.3%) (P = 0.001). Being a clustered patient was associated with being male and UK born, having pulmonary disease, a previous TB diagnosis, and a history of drug misuse or imprisonment. Our results suggest TB transmission in the UK decreased between 2010 and 2015, during which time TB incidence also decreased. Targeted cluster investigation and extended contact tracing should be aimed at those at risk of being in a transmission chain, including UK born individuals with social risk factors in clusters with a high proportion of patients having pulmonary disease. Surveillance, Transmission, Tuberculosis, Genotyping © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

American Journal of EpidemiologyOxford University Press

Published: Jun 7, 2018

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