The Biological Resolution of Malformations of the Central Nervous System

The Biological Resolution of Malformations of the Central Nervous System AbstractIT HAS BEEN known for years that the assembly of the nervous system is under genetic control. During the last 10 years, the genes that direct the formation of the brain and spinal cord have begun to be discovered at an amazing pace. Mutations in the fruit fly and advances in molecular genetics have led the way. Gene mutations that cause many of the malformations of the human brain and spinal cord are now known. This has many physician-scientists hoping that an understanding of cause might lead to cure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

The Biological Resolution of Malformations of the Central Nervous System

The Biological Resolution of Malformations of the Central Nervous System

FU N D A M EN TA L PROBLEMS T h e B i o l o g i c a l R e s o l u t i o n o f M a l f o r m a t i o n s o f t h e C e n t r a l N e r v o u s S y s t e m David G. McLone, M.D., Ph.D. IT HAS BEEN known for years that the assembly of the nervous system is under genetic control. D uring the last 10 years, the genes that direct the formation of the brain and spinal cord have begun to be discovered at an am azing pace. Mutations in the fruit fly and advances in molecular genetics have led the way. Gene mutations that cause many of the malformations of the human brain and spinal cord are now known. This has many physician-scientists hoping that an understanding of cause might lead to cure. (N e u ro su rg e ry 4 3 : 1 3 7 5 - 1 3 8 1 , 1 9 9 8 ) Keywords: Embryonic, Gene expression ow the fertilized egg can p ro d u ce an organ as c o m ­ tists have know n that cells com m u n icated w ith each other plex as the h u m a n b rain and spinal cord has been during em bryogenesis. S p em an n (28), during the 1920s, shrouded in m y ste ry until recently. Ironically, it is the show ed that neural determ ination resulted from contract of malformations of the central n erv o u s system that have led to the prospective neu roectod erm with the roof of the arch- the discovery of the gen es that control norm al developm ent. enteron (i.e., with the tissue that m oves from the dorsal lip of the blastopore forw ard beneath the region of ectod erm that Malformations have alw a y s p u zzled h u m ankind , and few later differentiates as neural tissue). things are more d ev astatin g to y o u n g parents than the birth of O bviously, "in d u ctiv e factors" w ere elaborated by one a child with a m alform ation , esp ecially one that involves the structure that determ ined the fate of adjacent structures. From central nervous system (CNS). T h e ancients blam ed the stars the time of discovery of the induction p h en om en a, it has been and then the gods. In recent...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199812000-00071
Publisher site
See Article on Publisher Site

Abstract

AbstractIT HAS BEEN known for years that the assembly of the nervous system is under genetic control. During the last 10 years, the genes that direct the formation of the brain and spinal cord have begun to be discovered at an amazing pace. Mutations in the fruit fly and advances in molecular genetics have led the way. Gene mutations that cause many of the malformations of the human brain and spinal cord are now known. This has many physician-scientists hoping that an understanding of cause might lead to cure.

Journal

NeurosurgeryOxford University Press

Published: Dec 1, 1998

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