Soluble Macrophage Mannose Receptor (sCD206/sMR) as a Biomarker in HIV-infection

Soluble Macrophage Mannose Receptor (sCD206/sMR) as a Biomarker in HIV-infection Abstract Macrophages play important roles during HIV-infection, reflected by changes in macrophage-activation biomarker sCD163. Here, we present data on the novel macrophage-activation biomarker soluble mannose receptor/CD206 (sMR/sCD206) in HIV-infection. We investigated sCD206 blood levels at baseline and follow-up with/without ART, in 212 patients with HIV-1, HIV-2, or dual infection. At baseline, there was no difference in sCD206 level between HIV-types, and sCD206 was unchanged at follow-up without ART. However, contrary to sCD163, sCD206 levels decreased significantly for both HIV-1 and HIV-2, but not for HIV-1/2 patients, during ART. Further investigations are needed to establish sCD206 as biomarker in HIV-infection. Macrophage, HIV, biomarker, sCD206, sMR, sCD163, HIV-1, HIV-2, AIDS, Guinea-Bissau © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Infectious Diseases Oxford University Press

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Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
ISSN
0022-1899
eISSN
1537-6613
D.O.I.
10.1093/infdis/jiy318
Publisher site
See Article on Publisher Site

Abstract

Abstract Macrophages play important roles during HIV-infection, reflected by changes in macrophage-activation biomarker sCD163. Here, we present data on the novel macrophage-activation biomarker soluble mannose receptor/CD206 (sMR/sCD206) in HIV-infection. We investigated sCD206 blood levels at baseline and follow-up with/without ART, in 212 patients with HIV-1, HIV-2, or dual infection. At baseline, there was no difference in sCD206 level between HIV-types, and sCD206 was unchanged at follow-up without ART. However, contrary to sCD163, sCD206 levels decreased significantly for both HIV-1 and HIV-2, but not for HIV-1/2 patients, during ART. Further investigations are needed to establish sCD206 as biomarker in HIV-infection. Macrophage, HIV, biomarker, sCD206, sMR, sCD163, HIV-1, HIV-2, AIDS, Guinea-Bissau © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

The Journal of Infectious DiseasesOxford University Press

Published: May 25, 2018

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