Restorative Neurosurgery: Opportunities for Restoration of Function in Acquired, Degenerative, and Idiopathic Neurological Diseases

Restorative Neurosurgery: Opportunities for Restoration of Function in Acquired, Degenerative,... AbstractHISTORICALLY, NEUROSURGERY HAS improved the environment of the nervous system to promote maximal spontaneous recovery of function. The population of patients whom we treat at present is a small portion of those who suffer from disabling neurological illnesses. Based on a combination of new technology, and advances in neuroscience, restorative neurosurgery is advancing the frontiers of our specialty, and providing the potential to restore lost function. Significant advancements in gene therapy, the discovery and delivery of neurotrophic factors, and cell transplantation now require neurosurgeons to broaden the scope of our practice so that it includes the restoration of function in an enormous number of patients with acquired, degenerative and idiopathic neurological diseases. In order to meet the present challenge, neurosurgeons must broaden our vision, our role, and our future educational goals. In this review, we summarize the landmark advances in the basic and clinical neurosciences and the results of clinical trials that are driving our evolution from passive reaction to disease to active attempts to restore lost central nervous system function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Restorative Neurosurgery: Opportunities for Restoration of Function in Acquired, Degenerative, and Idiopathic Neurological Diseases

Restorative Neurosurgery: Opportunities for Restoration of Function in Acquired, Degenerative, and Idiopathic Neurological Diseases

FUNDAMENTAL PROBLEMS Restorative Neurosurgery: Opportunities for Restoration of Function in Acquired, Degenerative, and Idiopathic Neurological Diseases Todd P. Thompson, M.D., L. Dade Lunsford, M.D., Douglas Kondziolka, M.D. D e p a rtm e n t o f N e u ro lo g ica l Surgery, U niversity o f Pittsburgh, Pittsburgh, Pennsylvania HISTORICALLY, N E U R O S U R G E R Y HAS improved the environment of the nervous system to promote maximal spontaneous recovery of function. The population of patients whom we treat at present is a small portion of those who suffer from disabling neurological illnesses. Based on a combination of new technology, and advances in neuroscience, restorative neurosurgery is advancing the frontiers of our specialty, and providing the potential to restore lost function. Significant advancements in gene therapy, the discovery and delivery of neurotrophic factors, and cell transplantation now require neurosurgeons to broaden the scope of our practice so that it includes the restoration of function in an enormous number of patients with acquired, degenerative and idiopathic neurological diseases. In order to meet the present challenge, neurosurgeons must broaden our vision, our role, and our future educational goals. In this review, we summarize the landmark advances in the basic and clinical neurosciences and the results of clinical trials that are driving our evolution from passive reaction to disease to active attempts to restore lost central nervous system function. (Neurosurgery 45:741-752, 1999) Key words: Cell transplantation, Central nervous system, Functional neurosurgery, Gene therapy, Immunosuppression, Neurotrophic factors, Restorative neurosurgery, Stereotactic surgery communication). Although affording som e m o d icu m of suc­ Don't ever prophesy: f o r i f you prophesy w rong, nobody will cess, this record is not sufficient to meet the current and future forget it; and if you prophesy right, nobody will remember it. needs of...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199910000-00001
Publisher site
See Article on Publisher Site

Abstract

AbstractHISTORICALLY, NEUROSURGERY HAS improved the environment of the nervous system to promote maximal spontaneous recovery of function. The population of patients whom we treat at present is a small portion of those who suffer from disabling neurological illnesses. Based on a combination of new technology, and advances in neuroscience, restorative neurosurgery is advancing the frontiers of our specialty, and providing the potential to restore lost function. Significant advancements in gene therapy, the discovery and delivery of neurotrophic factors, and cell transplantation now require neurosurgeons to broaden the scope of our practice so that it includes the restoration of function in an enormous number of patients with acquired, degenerative and idiopathic neurological diseases. In order to meet the present challenge, neurosurgeons must broaden our vision, our role, and our future educational goals. In this review, we summarize the landmark advances in the basic and clinical neurosciences and the results of clinical trials that are driving our evolution from passive reaction to disease to active attempts to restore lost central nervous system function.

Journal

NeurosurgeryOxford University Press

Published: Oct 1, 1999

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