Recurrence of Genital Infections with Nine HPV Vaccine Types (6, 11, 16, 18, 31, 33, 45, 52, and 58) among Men in the HPV Infection in Men (HIM) Study

Recurrence of Genital Infections with Nine HPV Vaccine Types (6, 11, 16, 18, 31, 33, 45, 52, and... Abstract Background The purpose of this study was to assess genital recurrence of HPV genotypes included in the 9-valent vaccine and investigate factors associated with recurrence among men in the HPV Infection in Men (HIM) Study. Methods Men were followed every six months for a median of 3.7 years. HPV genotypes were detected using Roche Linear Array. Factors associated with type-specific HPV recurrence (infections occurring after a ≥12-month infection-free period) were assessed. Results In type-specific analyses, 31% of prior prevalent and 20% of prior incident infections recurred. Among prevalent infections HPV types 52, 45, 16, 58 and 6 and among incident infections HPV types 58, 52, 18, 16, and 11 had the highest rates of recurrence. New sexual partners (male or female), and frequency of sexual intercourse with female partners were associated with HPV 6, 16, 31, and 58 infection recurrence. In grouped analyses, lifetime and new male sexual partners were associated with recurrence of prior incident infection with any of the nine HPV types. Discussion Recurrence of genital HPV infections is relatively common among men and associated with high-risk sexual behavior. Further studies are needed to understand the role of HPV recurrence in the etiology of HPV associated diseases. Human Papillomavirus (HPV), recurrence, redetection, men, HIM Study © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Infectious Diseases Oxford University Press

Recurrence of Genital Infections with Nine HPV Vaccine Types (6, 11, 16, 18, 31, 33, 45, 52, and 58) among Men in the HPV Infection in Men (HIM) Study

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Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
ISSN
0022-1899
eISSN
1537-6613
D.O.I.
10.1093/infdis/jiy300
Publisher site
See Article on Publisher Site

Abstract

Abstract Background The purpose of this study was to assess genital recurrence of HPV genotypes included in the 9-valent vaccine and investigate factors associated with recurrence among men in the HPV Infection in Men (HIM) Study. Methods Men were followed every six months for a median of 3.7 years. HPV genotypes were detected using Roche Linear Array. Factors associated with type-specific HPV recurrence (infections occurring after a ≥12-month infection-free period) were assessed. Results In type-specific analyses, 31% of prior prevalent and 20% of prior incident infections recurred. Among prevalent infections HPV types 52, 45, 16, 58 and 6 and among incident infections HPV types 58, 52, 18, 16, and 11 had the highest rates of recurrence. New sexual partners (male or female), and frequency of sexual intercourse with female partners were associated with HPV 6, 16, 31, and 58 infection recurrence. In grouped analyses, lifetime and new male sexual partners were associated with recurrence of prior incident infection with any of the nine HPV types. Discussion Recurrence of genital HPV infections is relatively common among men and associated with high-risk sexual behavior. Further studies are needed to understand the role of HPV recurrence in the etiology of HPV associated diseases. Human Papillomavirus (HPV), recurrence, redetection, men, HIM Study © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

The Journal of Infectious DiseasesOxford University Press

Published: May 24, 2018

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