Quality of Life of Adult Survivors of Germinomas Treated with Craniospinal Irradiation

Quality of Life of Adult Survivors of Germinomas Treated with Craniospinal Irradiation AbstractOBJECTIVE:To assess the quality of life (QOL) of a group of patients treated for intracranial germinoma with biopsy followed by prophylactic whole-neuraxis radiation therapy.METHODS:The Short-form-36 and Functional Assessment of Cancer Therapy QOL questionnaires were completed by 22 of 27 eligible adults treated with whole-neuraxis irradiation for biopsy-proven, marker-negative intracranial germinomas between 1976 and 1996. In addition, data were obtained regarding height and weight, medications, ability to work, and educational achievement.RESULTS:The patients' QOL was generally good. All of the patients are in or have completed high school; nine are in or have completed college, and five have advanced degrees. Patients rated themselves lower on the physical composite scale of the Short-form-36 (average, 46 versus 54 in a normal population). On the mental composite scale, patients rated themselves more favorably than the normal population (average, 54 versus 49 in a normal population). Patients were normally proportioned for height and weight, but female patients tended to be short. Age at radiation did not correlate with QOL.CONCLUSION:The QOL of adults treated for marker-negative germinoma with prophylactic whole-neuraxis irradiation is generally good. These data should serve as a benchmark for newer treatment protocols eliminating or reducing radiation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Quality of Life of Adult Survivors of Germinomas Treated with Craniospinal Irradiation

Quality of Life of Adult Survivors of Germinomas Treated with Craniospinal Irradiation Leslie N. Sutton, M.D., Jerilynn Radcliffe, Ph.D., Joel W . Goldwein, M.D., Peter Phillips, M.D., Anna J. Janss, M.D., Ph.D., Roger J. Packer, M.D., Huaqing Zhao, M.A. Departments of Neurosurgery (LNS), Neurooncology (PP, AJJ), and Biostatistics and Epidemiology (HZ), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of Neurosurgery (LNS), Clinical Psychology in Pediatrics (JR), Radiation Oncology (JW G ), and Neurooncology (PP), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; and Department of Neurology and Pediatrics (RJP), Children's National Medical Center, George Washington University, Washingon, District of Columbia O B JE C T IV E : To assess the quality of life (Q O L ) of a group of patients treated for intracranial germinoma with biopsy followed by prophylactic whole-neuraxis radiation therapy. M E T H O D S : The Short-form-36 and Functional Assessment of Cancer Therapy Q O L questionnaires w ere completed by 22 of 27 eligible adults treated w ith whole-neuraxis irradiation for biopsy-proven, marker-negative intracra­ nial germinomas between 1976 and 1996. In addition, data w ere obtained regarding height and weight, medications, ability to work, and educational achievem ent. RESULTS: The patients' Q O L was generally good. All of the patients are in or have completed high school; nine are in or have completed college, and five have advanced degrees. Patients rated themselves low er on the physical composite scale of the Short-form-36 (average, 46 versus 54 in a normal population). O n the mental composite scale, patients rated themselves more favorably than the normal population (average, 54 versus 49 in a normal population). Patients w ere norm ally proportioned for height and weight, but female patients tended to be short. Age at radiation did not correlate w ith Q O L . C O N C L U S IO N :...
Loading next page...
 
/lp/ou_press/quality-of-life-of-adult-survivors-of-germinomas-treated-with-KBLrVske0H
Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199912000-00002
Publisher site
See Article on Publisher Site

Abstract

AbstractOBJECTIVE:To assess the quality of life (QOL) of a group of patients treated for intracranial germinoma with biopsy followed by prophylactic whole-neuraxis radiation therapy.METHODS:The Short-form-36 and Functional Assessment of Cancer Therapy QOL questionnaires were completed by 22 of 27 eligible adults treated with whole-neuraxis irradiation for biopsy-proven, marker-negative intracranial germinomas between 1976 and 1996. In addition, data were obtained regarding height and weight, medications, ability to work, and educational achievement.RESULTS:The patients' QOL was generally good. All of the patients are in or have completed high school; nine are in or have completed college, and five have advanced degrees. Patients rated themselves lower on the physical composite scale of the Short-form-36 (average, 46 versus 54 in a normal population). On the mental composite scale, patients rated themselves more favorably than the normal population (average, 54 versus 49 in a normal population). Patients were normally proportioned for height and weight, but female patients tended to be short. Age at radiation did not correlate with QOL.CONCLUSION:The QOL of adults treated for marker-negative germinoma with prophylactic whole-neuraxis irradiation is generally good. These data should serve as a benchmark for newer treatment protocols eliminating or reducing radiation.

Journal

NeurosurgeryOxford University Press

Published: Dec 1, 1999

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off