Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages

Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages AbstractTHE FAILURE OF the adult mammalian central nervous system (CNS) to regenerate after injury has long been viewed as a unique phenomenon resulting from the specific nature of this system. The finding that some CNS axons could be induced to regrow if provided with a permissive environment suggested that this failure is a result, at least in part, of the nature of the postinjury neuronal environment. It was further shown that the involvement of inflammatory cells, particularly macrophages, in postinjury processes in the CNS is limited. We have suggested that, to achieve recovery after injury, the adult mammalian CNS may require the assistance of the same postinjury factors as those involved in the recovery of spontaneously regenerating systems but that its accessibility to such assistance is restricted. Accordingly, we proposed that it might be possible to circumvent the restriction, allowing regeneration to occur. We showed that the implantation of autologous macrophages, which had been prestimulated by exposure to a regenerative (sciatic) nerve, into completely transected spinal cords of adult rats led to partial motor recovery. This treatment intervenes in the postinjury process by simulating in the axotomized CNS the events that occur naturally in spontaneously regenerating systems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages

Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages

Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages Michal Schwartz, Ph.D., Orly Lazarov-Spiegler, M.Sc., si Otto Rapalino, M .D ., Ivgenia Agranov, M .D ., tf Gad Velan, M .D ., Moshe Hadani, M .D. Department of Neurobiology, The W eizm ann Institute of Science, Rehovot, Israel THE FAILURE O F t h e a d u l t m a m m a l i a n c e n t r a l n e r v o u s system ( C N S ) to r e g e n e r a t e a f t e r in ju r y has lo n g b e e n v i e w e d as a unique p h e n o m e n o n r e s u lt in g f r o m t h e s p e c ific n a t u r e o f this system . T h e f in d in g t h a t s o m e C N S a x o n s c o u ld be induced to r e g r o w if p r o v i d e d w i t h a p e r m is s iv e e n v i r o n m e n t suggested t h a t this f a i l u r e is a re s u lt, a t least in p a r t, of the nature o f t h e p o s t i n j u r y n e u r o n a l e n v i r o n m e n t . It w as f u r t h e r s h o w n t h a t th e i n v o l v e m e n t o f i n f l a m m a t o r y cells, p a rtic u la rly m a c r o p h a g e s , in p o s t i n j u r y processes in th e C N S is l i m i t e d . W e h a v e suggested t h a t , to a c h ie v e recovery a fte r i n j u r y , t h e a d u l t m a m m a l i a n C N S m a y r e q u ir e th e assistance o f th e s a m e p o s t in ju r y fa c to r s as th o s e involved in th e r e c o v e r y o f s p o n t a n e o u s ly r e g e n e r a t i n g systems b u t t h a t its a c c e s s ib ility to such assistance is restricted. A c c o r d i n g l y , w e p r o p o s e d t h a t it m i g h t be possible to c i r c u m v e n t th e r e s t r ic t io n , a l l o w i n g r e g e n e r a t i o n to occur. W e s h o w e d t h a t t h e i m p l a n t a t i o n o f a u to lo g o u s m a c r o p h a g e s , w h i c h h a d b e e n p r e s t i m u l a t e d by e x p o s u r e to a regenerative (s c ia tic ) n e r v e , in t o c o m p l e t e l y t r a n s e c te d spinal co rd s o f a d u l t rats led to p a r t ia l m o t o r r e c o...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199905000-00057
Publisher site
See Article on Publisher Site

Abstract

AbstractTHE FAILURE OF the adult mammalian central nervous system (CNS) to regenerate after injury has long been viewed as a unique phenomenon resulting from the specific nature of this system. The finding that some CNS axons could be induced to regrow if provided with a permissive environment suggested that this failure is a result, at least in part, of the nature of the postinjury neuronal environment. It was further shown that the involvement of inflammatory cells, particularly macrophages, in postinjury processes in the CNS is limited. We have suggested that, to achieve recovery after injury, the adult mammalian CNS may require the assistance of the same postinjury factors as those involved in the recovery of spontaneously regenerating systems but that its accessibility to such assistance is restricted. Accordingly, we proposed that it might be possible to circumvent the restriction, allowing regeneration to occur. We showed that the implantation of autologous macrophages, which had been prestimulated by exposure to a regenerative (sciatic) nerve, into completely transected spinal cords of adult rats led to partial motor recovery. This treatment intervenes in the postinjury process by simulating in the axotomized CNS the events that occur naturally in spontaneously regenerating systems.

Journal

NeurosurgeryOxford University Press

Published: May 1, 1999

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