PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas

PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas AbstractOBJECTIVEThe role of chemotherapy in the treatment of low-grade oligodendrogliomas and oligoastrocytomas is still unclear. A Phase II study was conducted to determine the benefits and toxicity of the procarbazine, lomustine, and vincristine (PCV) regimen in patients with low-grade oligodendrogliomas and oligoastrocytomas recurrent after surgery alone or surgery with radiotherapy.METHODSPatients with both enhancing and nonenhancing tumors were treated with up to six cycles of standard PCV, and response was evaluated by conventional criteria based on computed tomography or magnetic resonance imaging.RESULTSSixteen of 26 patients (62%) responded to PCV: 3 (12%) experienced complete response, 13 (50%) experienced partial response, 8 (31 %) had stable disease, and 2 (8%) had progressive disease. All symptomatic patients who responded and three with stable disease improved in seizure frequency, lateralizing signs, and symptoms of intracranial hypertension. The response rate for patients with enhancing lesions revealed by computed tomographv or magnetic resonance imaging (74%) was significantly higher than that of patients with nonenhancing lesions (29%) (P < 0.05). Both oligodendrogliomas and oligoastrocytomas responded to PCV, with complete responses occurring in association with pure tumors only. The median time to tumor progression of all 26 patients was 24 months and was significantly longer for those with oligodendrogliomas compared with those with oligoastrocytomas (32 versus 12 mo) (P < 0.001). Chemotherapy was well tolerated, with mild hematological toxicity and rare skin rashes being the most frequent sequelae.CONCLUSIONThese results suggest that chemotherapy with PCV is effective in the treatment of recurrent low-grade oligodendrogliomas and oligoastrocytomas. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas

PCV Chemotherapy for Recurrent Oligodendrogliomas and Oligoastrocytomas

CLINICAL STUDIES PCV Chemotherapy for Recurrent Oligodendrogliom as and Oligoastrocytomas Riccardo Soffietti, M.D., Roberta Ruda, M.D., Gianni Boris Bradac, M.D., Davide Schiffer, M.D. Divisions of Neurology (RS, RR, DS) and Neuroradiology (GBB), Department of Neuroscience, University of Torino, Torino, Italy O B JECTIV E: The role of chemotherapy in the treatment of low-grade oligodendrogliomas and oligoastrocytomas is still unclear. A Phase II study was conducted to determine the benefits and toxicity of the procarbazine, lomustine, and vincristine (PCV) regimen in patients with low-grade oligodendrogliomas and oligoastrocytomas recurrent after surgery alone or surgery with radiotherapy. M E T H O D S : Patients with both enhancing and nonenhancing tumors were treated with up to six cycles of standard P C V , and response was evaluated by conventional criteria based on computed tomography or magnetic reso­ nance imaging. RESU LTS: Sixteen of 26 patients (6 2 % ) responded to P C V : 3 (1 2 % ) experienced complete response, 13 (50%) experienced partial response, 8 (31 % ) had stable disease, and 2 (8 % ) had progressive disease. A ll symptomatic patients who responded and three with stable disease improved in seizure frequency, lateralizing signs, and symptoms of intracranial hypertension. The response rate for patients with enhancing lesions revealed by computed tomographv or magnetic resonance imaging (7 4 % ) was significantly higher than that of patients with nonenhancing lesions (29%) ( P < 0.05). Both oligodendrogliom as and oligoastrocytom as responded to P C V , with complete responses o ccu rrin g in association with pure tumors only. The median time to tumor progression of all 26 patients was 24 months and was significantly longer for those with oligodendrogliom as compared with those with oligoastrocy­ tomas (32 versus 12 mo) (P < 0.001). Chem otherapy was well tolerated, with mild hem atological toxicity and rare skin rashes being the...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199811000-00035
Publisher site
See Article on Publisher Site

Abstract

AbstractOBJECTIVEThe role of chemotherapy in the treatment of low-grade oligodendrogliomas and oligoastrocytomas is still unclear. A Phase II study was conducted to determine the benefits and toxicity of the procarbazine, lomustine, and vincristine (PCV) regimen in patients with low-grade oligodendrogliomas and oligoastrocytomas recurrent after surgery alone or surgery with radiotherapy.METHODSPatients with both enhancing and nonenhancing tumors were treated with up to six cycles of standard PCV, and response was evaluated by conventional criteria based on computed tomography or magnetic resonance imaging.RESULTSSixteen of 26 patients (62%) responded to PCV: 3 (12%) experienced complete response, 13 (50%) experienced partial response, 8 (31 %) had stable disease, and 2 (8%) had progressive disease. All symptomatic patients who responded and three with stable disease improved in seizure frequency, lateralizing signs, and symptoms of intracranial hypertension. The response rate for patients with enhancing lesions revealed by computed tomographv or magnetic resonance imaging (74%) was significantly higher than that of patients with nonenhancing lesions (29%) (P < 0.05). Both oligodendrogliomas and oligoastrocytomas responded to PCV, with complete responses occurring in association with pure tumors only. The median time to tumor progression of all 26 patients was 24 months and was significantly longer for those with oligodendrogliomas compared with those with oligoastrocytomas (32 versus 12 mo) (P < 0.001). Chemotherapy was well tolerated, with mild hematological toxicity and rare skin rashes being the most frequent sequelae.CONCLUSIONThese results suggest that chemotherapy with PCV is effective in the treatment of recurrent low-grade oligodendrogliomas and oligoastrocytomas.

Journal

NeurosurgeryOxford University Press

Published: Nov 1, 1998

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