Patients with Spinal Cord Cavernous Malformations Are at an Increased Risk for Multiple Neuraxis Cavernous Malformations

Patients with Spinal Cord Cavernous Malformations Are at an Increased Risk for Multiple Neuraxis... AbstractOBJECTIVE:To determine the prevalence of multiple neuraxis cavernous malformations in patients who initially presented with intramedullary spinal cord (IMSC) cavernous malformations without knowledge of cavernous malformations elsewhere in the neuraxis.METHODS:Hospital records and radiographic files were analyzed for 17 patients who subsequently underwent surgical resection of an IMSC cavernous malformation (histologically proven) and also underwent brain magnetic resonance imaging studies. These 17 patients represented a subset of 32 patients who underwent surgical resection of an IMSC cavernous malformation during the same period.RESULTS:Of 17 patients, 8 (47%) harbored multiple cavernous malformations. This group was composed of five women and three men (mean age, 35.9 yr). There were four Caucasian and four Hispanic patients.CONCLUSION:The prevalence of multiple cavernous malformations in the neuraxis seems to be increased in patients who harbor IMSC cavernous malformations. This finding has important implications for the evaluation and management of these patients and, in some cases, their family members. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Patients with Spinal Cord Cavernous Malformations Are at an Increased Risk for Multiple Neuraxis Cavernous Malformations

Patients with Spinal Cord Cavernous Malformations Are at an Increased Risk for Multiple Neuraxis Cavernous Malformations

CLINICAL STUDIES Patients with Spinal Cord Cavernous Malformations Are at an Increased Risk for Multiple Neuraxis Cavernous Malformations A. Giancarlo Vishteh, M.D., Joseph M. Zabramski, M.D., Robert F. Spetzler, M.D. Division of Neurological Surgery, Barrow Neurological Institute, St. )oseph's Hospital and Medical Center, Phoenix, Arizona O BJEC T IV E: To determine the prevalence of multiple neuraxis cavernous malformations in patients who initially presented with intramedullary spinal cord (IM SC) cavernous malformations without knowledge of cavernous malformations elsewhere in the neuraxis. M ET H O D S: Hospital records and radiographic files were analyzed for 17 patients who subsequently underwent surgical resection of an IM SC cavernous malformation (histologically proven) and also underwent brain magnetic resonance imaging studies. These 17 patients represented a subset of 32 patients who underwent surgical resection of an IM SC cavernous malformation during the same period. RESULTS: O f 17 patients, 8 (4 7 % ) harbored multiple cavernous malformations. This group was composed of five women and three men (mean age, 35.9 yr). There were four Caucasian and four Hispanic patients. C O N C L U S IO N : The prevalence of multiple cavernous malformations in the neuraxis seems to be increased in patients who harbor IMSC cavernous malformations. This finding has important implications for the evaluation and management of these patients and, in some cases, their family members. (N eu ro su rg ery 45:30-33, 1999) Key words: Cavernous malformations, Neuraxis, Spinal cord s the literature on spinal cord cavernous malforma­ PATIENTS A N D M ET H O D S tions continues to grow (1, 3-10, 16, 17), there are Between 1985 and 1998, the senior authors (RFS, JMZ) per­ virtually no studies examining the prevalence of mul­ formed resection of histologically proven IMSC cavernous mal­ tiple neuraxis cavernous malformations in patients who ini­ formations...
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Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199907000-00008
Publisher site
See Article on Publisher Site

Abstract

AbstractOBJECTIVE:To determine the prevalence of multiple neuraxis cavernous malformations in patients who initially presented with intramedullary spinal cord (IMSC) cavernous malformations without knowledge of cavernous malformations elsewhere in the neuraxis.METHODS:Hospital records and radiographic files were analyzed for 17 patients who subsequently underwent surgical resection of an IMSC cavernous malformation (histologically proven) and also underwent brain magnetic resonance imaging studies. These 17 patients represented a subset of 32 patients who underwent surgical resection of an IMSC cavernous malformation during the same period.RESULTS:Of 17 patients, 8 (47%) harbored multiple cavernous malformations. This group was composed of five women and three men (mean age, 35.9 yr). There were four Caucasian and four Hispanic patients.CONCLUSION:The prevalence of multiple cavernous malformations in the neuraxis seems to be increased in patients who harbor IMSC cavernous malformations. This finding has important implications for the evaluation and management of these patients and, in some cases, their family members.

Journal

NeurosurgeryOxford University Press

Published: Jul 1, 1999

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