Oxygen-dependent regulation of immune checkpoint mechanisms

Akio Ohta

doi:10.1093/intimm/dxy038

The principles of engineering immune cells to treat cancer

Lim, W. A.; June, C. H

Cellular and humoral immunity to different types of human neoplasms

Hellström, I.; Hellström, K. E.; Pierce, G. E.; Yang, J. P

Cellular constituents of immune escape within the tumor microenvironment

Kerkar, S. P.; Restifo, N. P

Obstacles posed by the tumor microenvironment to T cell activity: a case for synergistic therapies

Anderson, K. G.; Stromnes, I. M.; Greenberg, P. D

Immunosuppressive strategies that are mediated by tumor cells

Rabinovich, G. A.; Gabrilovich, D.; Sotomayor, E. M

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

Iwai, Y.; Ishida, M.; Tanaka, Y.; Okazaki, T.; Honjo, T.; Minato, N

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

Kwon, E. D.; Hurwitz, A. A.; Foster, B. A.

Immune checkpoint inhibitors for cancer therapy: clinical efficacy and safety

Azoury, S. C.; Straughan, D. M.; Shukla, V

Targeting T cell co-receptors for cancer therapy

Callahan, M. K.; Postow, M. A.; Wolchok, J. D

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

Chambers, C. A.; Kuhns, M. S.; Egen, J. G.; Allison, J. P

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

Parry, R. V.; Chemnitz, J. M.; Frauwirth, K. A.

PD-1 and PD-1 ligands: from discovery to clinical application

Okazaki, T.; Honjo, T

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

Okazaki, T.; Chikuma, S.; Iwai, Y.; Fagarasan, S.; Honjo, T

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

Waterhouse, P.; Penninger, J. M.; Timms, E.

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

Shull, M. M.; Ormsby, I.; Kier, A. B.

FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents

Ohkura, N.; Hamaguchi, M.; Sakaguchi, S

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D.; Gavin, M. A.; Rudensky, A. Y

Exploiting tumour hypoxia in cancer treatment

Brown, J. M.; Wilson, W. R

Hypoxia in cancer: significance and impact on clinical outcome

Vaupel, P.; Mayer, A

Inflammatory hypoxia: role of hypoxia-inducible factor

Karhausen, J.; Haase, V. H.; Colgan, S. P

The ‘danger’ sensors that STOP the immune response: the A2 adenosine receptors

Sitkovsky, M. V.; Ohta, A

HIF transcription factors, inflammation, and immunity

Palazon, A.; Goldrath, A. W.; Nizet, V.; Johnson, R. S

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J.; Furuta, G. T.; Tomaszewski, J. E.; Johnson, R. S.; Colgan, S. P.; Haase, V. H

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Clambey, E. T.; McNamee, E. N.; Westrich, J. A.

Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists

Sitkovsky, M. V.; Hatfield, S.; Abbott, R.; Belikoff, B.; Lukashev, D.; Ohta, A

Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway

Choukèr, A.; Thiel, M.; Lukashev, D.

Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible

Ohta, A.; Madasu, M.; Subramanian, M.

Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury

Thiel, M.; Chouker, A.; Ohta, A.

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

Hatfield, S. M.; Kjaergaard, J.; Lukashev, D.

Immunological mechanisms of the antitumor effects of supplemental oxygenation

Hatfield, S. M.; Kjaergaard, J.; Lukashev, D.

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J.; Wong, W. J.; Simon, M. C

Hypoxia-inducible factors: master regulators of cancer progression

Schito, L.; Semenza, G. L

Regulation of cell proliferation by hypoxia-inducible factors

Hubbi, M. E.; Semenza, G. L

Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production

Tripmacher, R.; Gaber, T.; Dziurla, R.

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

Pollizzi, K. N.; Powell, J. D

Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation

Loeffler, D. A.; Juneau, P. L.; Masserant, S

Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells

Naldini, A.; Carraro, F.; Silvestri, S.; Bocci, V

Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions

Caldwell, C. C.; Kojima, H.; Lukashev, D.

Culturing at atmospheric oxygen levels impacts lymphocyte function

Atkuri, K. R.; Herzenberg, L. A.; Herzenberg, L. A

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

van der Windt, G. J.; O’Sullivan, D.; Everts, B.

Fueling immunity: insights into metabolism and lymphocyte function

Pearce, E. L.; Poffenberger, M. C.; Chang, C. H.; Jones, R. G

Metabolic competition in the tumor microenvironment is a driver of cancer progression

Chang, C. H.; Qiu, J.; O’Sullivan, D.

The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction

Scharping, N. E.; Menk, A. V.; Moreci, R. S.

Mitochondrial dynamics controls T cell fate through metabolic programming

Buck, M. D.; O’Sullivan, D.; Klein Geltink, R. I.

Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction

Gill, T.; Levine, A. D

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling

Sena, L. A.; Li, S.; Jairaman, A.

Mitochondria in the regulation of innate and adaptive immunity

Weinberg, S. E.; Sena, L. A.; Chandel, N. S

Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

Chamoto, K.; Chowdhury, P. S.; Kumar, A.

Metabolic pathways in immune cell activation and quiescence

Pearce, E. L.; Pearce, E. J

HIF-1alpha is essential for myeloid cell-mediated inflammation

Cramer, T.; Yamanishi, Y.; Clausen, B. E.

Interdependence of hypoxic and innate immune responses

Nizet, V.; Johnson, R. S

A metabolic immune checkpoint: adenosine in tumor microenvironment

Ohta, A

Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes

Lukashev, D.; Caldwell, C.; Ohta, A.; Chen, P.; Sitkovsky, M

Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes

Lukashev, D.; Klebanov, B.; Kojima, H.

Enhanced interferon-gamma gene expression in T cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice

Guo, J.; Lu, W.; Shimoda, L. A.; Semenza, G. L.; Georas, S. N

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Doedens, A. L.; Phan, A. T.; Stradner, M. H.

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z.; Wang, R.; Huang, G.

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

Dang, E. V.; Barbi, J.; Yang, H. Y.

Purinergic signaling during inflammation

Eltzschig, H. K.; Sitkovsky, M. V.; Robson, S. C

Tumor-Induced Immune Suppression

Ohta, A.; Sitkovsky, M; Gabrilovich, D. I.; Hurwitz, A. A

Ecto-5’-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury

Volmer, J. B.; Thompson, L. F.; Blackburn, M. R

Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia

Grenz, A.; Zhang, H.; Weingart, J.

Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

Ohta, A.; Sitkovsky, M

Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors

Sitkovsky, M. V.; Lukashev, D.; Apasov, S.

A2A adenosine receptor protects tumors from antitumor T cells

Ohta, A.; Gorelik, E.; Prasad, S. J.

CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis

Stagg, J.; Divisekera, U.; Duret, H.

The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine

Blay, J.; White, T. D.; Hoskin, D. W

Commentary: a metabolic immune checkpoint: adenosine in tumor microenvironment

Vaupel, P.; Multhoff, G

Ecto-5’-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

Synnestvedt, K.; Furuta, G. T.; Comerford, K. M.

Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism

Eltzschig, H. K.; Thompson, L. F.; Karhausen, J.

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Yokosuka, T.; Takamatsu, M.; Kobayashi-Imanishi, W.; Hashimoto-Tane, A.; Azuma, M.; Saito, T

Mechanisms of hypoxia-mediated immune escape in cancer

Barsoum, I. B.; Koti, M.; Siemens, D. R.; Graham, C. H

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A.; Condamine, T.; Lu, L.

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Noman, M. Z.; Desantis, G.; Janji, B.

Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs

Allard, B.; Pommey, S.; Smyth, M. J.; Stagg, J

Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition

Sevigny, C. P.; Li, L.; Awad, A. S.

Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection

Kinsey, G. R.; Huang, L.; Jaworska, K.

The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

Ohta, A.; Kini, R.; Ohta, A.; Subramanian, M.; Madasu, M.; Sitkovsky, M

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Chen, W.; Jin, W.; Hardegen, N.

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

Guo, X.; Xue, H.; Shao, Q.

Cutting edge: hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1

Hasmim, M.; Noman, M. Z.; Messai, Y.

Transforming growth factor-β signaling enhancement by long-term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells

Furuta, C.; Miyamoto, T.; Takagi, T.

Hypoxia-inducible factor-1α activates the transforming growth factor-β/SMAD3 pathway in kidney tubular epithelial cells

Kushida, N.; Nomura, S.; Mimura, I.

A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

Zarek, P. E.; Huang, C. T.; Lutz, E. R.

Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine

Fernández, P.; Trzaska, S.; Wilder, T.

Absence of the adenosine A(2A) receptor attenuates hypertrophic scarring in mice

Hu, X.; Ran, H.; Dechang, W.; Yibing, W.; Yongqiang, F.; Qiang, L

The A2aR adenosine receptor controls cytokine production in iNKT cells

Nowak, M.; Lynch, L.; Yue, S.

Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms

Haskó, G.; Kuhel, D. G.; Chen, J. F.

Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells

Panther, E.; Corinti, S.; Idzko, M.

Development and maintenance of regulatory T cells

Ohkura, N.; Kitagawa, Y.; Sakaguchi, S

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

Sakaguchi, S

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody

Onizuka, S.; Tawara, I.; Shimizu, J.; Sakaguchi, S.; Fujita, T.; Nakayama, E

Hypoxic culture conditions enhance the generation of regulatory T cells

Neildez-Nguyen, T. M.; Bigot, J.; Da Rocha, S.

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells

Facciabene, A.; Peng, X.; Hagemann, I. S.

T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5’-adenosine monophosphate to adenosine

Kobie, J. J.; Shah, P. R.; Yang, L.; Rebhahn, J. A.; Fowell, D. J.; Mosmann, T. R

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Deaglio, S.; Dwyer, K. M.; Gao, W.

Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer

Mandapathil, M.; Szczepanski, M. J.; Szajnik, M.

Extracellular adenosine-mediated modulation of regulatory T cells

Ohta, A.; Sitkovsky, M

Adenosine A2A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease

Han, K. L.; Thomas, S. V.; Koontz, S. M.

Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells

Ryzhov, S.; Novitskiy, S. V.; Goldstein, A. E.

Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma

Iannone, R.; Miele, L.; Maiolino, P.; Pinto, A.; Morello, S

Host A(2B) adenosine receptors promote carcinoma growth

Ryzhov, S.; Novitskiy, S. V.; Zaynagetdinov, R.

Adenosine A2B receptor blockade slows growth of bladder and breast tumors

Cekic, C.; Sag, D.; Li, Y.; Theodorescu, D.; Strieter, R. M.; Linden, J

Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor

Ben Addi, A.; Lefort, A.; Hua, X.

Adenosine receptors in regulation of dendritic cell differentiation and function

Novitskiy, S. V.; Ryzhov, S.; Zaynagetdinov, R.

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

Csoka, B.; Selmeczy, Z.; Koscso, B.

Divergent effects of hypoxia on dendritic cell functions

Mancino, A.; Schioppa, T.; Larghi, P.

Reoxygenation of hypoxia-differentiateddendritic cells induces Th1 and Th17 cell differentiation

Wang, Q.; Liu, C.; Zhu, F.

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells

Sethumadhavan, S.; Silva, M.; Philbrook, P.

Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor

Mittal, D.; Young, A.; Stannard, K.

Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced antitumor T-cell responses

Beavis, P. A.; Milenkovski, N.; Henderson, M. A.

Emerging concepts of T cell metabolism as a target of immunotherapy

Chang, C. H.; Pearce, E. L

Clinical significance of T cell metabolic reprogramming in cancer

Herbel, C.; Patsoukis, N.; Bardhan, K.; Seth, P.; Weaver, J. D.; Boussiotis, V. A

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo

Blagih, J.; Coulombe, F.; Vincent, E. E.

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

Eikawa, S.; Nishida, M.; Mizukami, S.; Yamazaki, C.; Nakayama, E.; Udono, H

Hypoxia: a key player in antitumor immune response. A review in the theme: cellular responses to hypoxia

Noman, M. Z.; Hasmim, M.; Messai, Y.

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L

Drug penetration in solid tumours

Minchinton, A. I.; Tannock, I. F

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W.; Cao, Y.; Moeller, B

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Oxygen-dependent regulation of immune checkpoint mechanisms

Oxygen-dependent regulation of immune checkpoint mechanisms

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Oxygen-dependent regulation of immune checkpoint mechanisms

Oxygen-dependent regulation of immune checkpoint mechanisms

Abstract

Journal

Recommended Articles

References

Our policy towards the use of cookies