Abiotic stress, Arabidopsis, ascorbate, chloroplast proteome, heat shock transcription factorA1b, (p)ppGpp, phytochrome, plant growth, productivity, retrograde signals Mechanisms that protect against abiotic stress are essential for plant survival, yet their activation generally comes at the expense of growth and productivity, which is particularly serious for agriculture. Recent developments in molecular genetics have contributed substantially to our understanding of the basis of abiotic stress defense. Progress has also been made towards understanding how plants control the switch between growth and defense, especially with regard to timing and mechanism. This ongoing research is critical for the improvement of crop plants. Cell proliferation and growth require nutrients, biosynthetic capacity and energy. Restricting any one of these factors will lead to arrested growth and eventually death. To ensure their survival it is therefore necessary for living organisms to anticipate changes in the environment that might affect their capacity to grow, and then to mount an effective acclimatory response. This is particularly important in plants, which are typically immobile and encounter large fluctuations in temperature, light, humidity and nutrient availability in their natural environment (see Box 1). Environmental stress causes massive agricultural losses (Godfray et al., 2010; Cramer et al., 2011), and improving crop tolerance is a major goal of crop improvement programs. However, tolerance can come with trade-offs; for example, it has long been known that stress-tolerant plants have lower growth rates and productivity (reviewed by Chapin, 1991). Therefore, in addition to understanding the basis of tolerance, it is also important to understand the trade-offs between tolerance and growth/productivity for effective crop improvement. Box 1. Plant growth during abiotic stress Carbohydrate resources and energy generated by photosynthesis (circular arrows) are allocated to growth and reproduction. Nutrient limitation or abiotic stress exposure can limit growth and also lead to over-excitation of the photosynthetic electron transport chain and the production of potentially damaging ROS. Timely perception of stress leads to the modulation of plant growth and the activation of defense and acclimation pathways that can act within specific plant organs, or across the entire plant. Key players in the control of plant growth during abiotic stress are shown. Chloro, chloroplast; GA, gibberellins; BR, brassinosteroids; SA, salicylic acid; ET, ethylene. The impact of abiotic stress on plant performance is being explored at many different levels, in a great variety of model and crop species, and includes metabolic/physiological responses, molecular signaling pathways, ecophysiology and crop breeding studies. In addition, abiotic stress is not a single entity but rather comprises all the environmental perturbations that plants may encounter in nature. Consequently, the literature on abiotic stress responses is vast, and covers very diverse research areas. Here, we focus on a selection of recent advances made in our understanding of the molecular mechanisms that control plant growth during abiotic stress. Nutrient and water limitation: the root perspective Nutrient limitation has drastic effects on plant growth and development. Under mild nutrient deprivation plant architecture may be modified to increase nutrient uptake, while severe nutrient limitation may lead to complete growth arrest. Roots are essential for water and nutrient uptake, but also serve a variety of other functions, such as forming symbioses with other microorganisms in the rhizosphere, anchoring the plant to the soil, and acting as storage organs. Consequently, roots are essential for optimal plant productivity. Many abiotic stresses are first encountered at the root level often leading to changes in root biomass and architecture. For example, primary root growth stops when Arabidopsis seedlings are transferred to media without phosphate. This growth arrest is the consequence of a signaling pathway mediated by STOP1, ALMT1 and LPR2 (Balzergue et al., 2017). Strikingly, knockout mutants of these genes lose the root growth arrest response on phosphate removal, indicating that root growth arrest is not a result of metabolic limitation. Importantly, when roots encounter changes in environmental conditions they will change growth direction in order to optimize plant survival. Such directional changes in response to stimuli (tropisms) include where roots sense the soil water content and grow towards water to avoid dry soil by either changing direction or halting growth. Despite water sensing being the subject of very early plant physiology studies, until recently the mechanisms of this growth response were essentially unknown. Some genes required for hydrotropism, such as MIZ1 and MIZ2/GNOM, have now been identified (Kobayashi et al., 2007; Miyazawa et al., 2008), and a role identified for the action of plant hormones such as auxin, ABA and cytokinin (Moriwaki et al., 2011; Moriwaki et al., 2012; Saucedo et al., 2012). More recently the site of water perception and growth control was localized to the root cortex (Dietrich et al., 2017), and progress and perspectives in the active hydrotropism field are reviewed in this issue by Dietrich (2018). The review highlights the many outstanding questions that remain regarding the signaling pathways involved in hydrotropism, as well as the need for further research in this area. Indeed, it has been suggested that the genes involved in hydrotropism could be important targets for crop improvement by enhancing drought avoidance. A recent demonstration that a robust hydrotropic response leads to better growth under drought and partial lateral irrigation in different maize cultivars strongly supports this notion (Eapen et al., 2017). Growing pains: abiotic stress Abiotic stress leads to altered biosynthetic capacity and nutrient acquisition that can inhibit plant growth. This phenomenon is documented in many research papers on model and crop species alike. Consequently, research into understanding the responses to abiotic stress has moved to the forefront over the past decade, leading to the discovery of several signaling pathways involving a large number of genes, proteins and post-translational modifications. These include the MAPK, ABF/bZIP, Ca2+-CBL-CIPK and CBF/DREB signaling pathways, which employ numerous stress-responsive transcription factors to orchestrate the downstream responses required to mount an effective defense to specific abiotic challenges (Wang et al., 2016; Zhu, 2016). Importantly, these molecular signaling pathways can anticipate the effects of abiotic stress to regulate the balance between growth and acclimation. More recently, efforts into understanding how plant growth is regulated under stress conditions has resulted in the identification of candidate genes that may integrate both processes. For example, the molecular mechanisms that control leaf growth under mild drought conditions link both growth and transcriptional responses to the circadian clock. Specifically, two ETHYLENE RESPONSE FACTORS (ERFs), ERF2 and ERF8, were found to affect leaf growth under drought and well-watered conditions (Dubois et al., 2017). Interestingly, in the same study the specific up-regulation of three genes encoding growth-repressing DELLA proteins was observed during the early drought response (Dubois et al., 2017). DELLA proteins have previously been shown to accumulate under nutrient deficiency, low temperature treatment and in response to salt stress (Achard et al., 2008; Xie et al., 2016). DELLAs promote stress-inducible anthocyanin biosynthesis through the formation of a JAZ–DELLA–MYBL2 complex (Xie et al., 2016) and can also promote ROS scavenging to delay cell death (Achard et al., 2008). Stress-induced anthocyanin accumulation is significantly inhibited in della mutants (Xie et al., 2016), while under salt stress della quadruple mutants produce significantly more ROS than the wild type (Achard et al., 2008). DELLA proteins therefore promote survival under abiotic stress conditions. Interestingly, reduced anthocyanin accumulation in response to high light was also observed in the ascorbate-deficient mutants vtc2-1 and vtc2-4, yet both vtc mutants experienced identical levels of photodamage compared to wild type. This suggests that ascorbate is not essential for photoprotection during high light, but intriguingly is required for the accumulation of rosette biomass under low-light and short-day conditions (Plumb et al., 2018). Signal transduction pathways mediated by phytohormones can play a critical role in abiotic stress responses (reviewed by Verma et al., 2016). For example, ABA plays a key role in stress responses, while auxin plays a major role in promoting plant growth. The interplay between phytohormones is therefore an important mechanism for balancing growth and stress resistance. Brassinosteroids are a class of plant steroid hormones that promote growth via the activation of the transcription factors BZR1 and BES1. A recent study has shown that drought stress represses the brassinosteroid signaling pathway, and thereby growth, by promoting the degradation of BES1 via ubiquitination and selective autophagy (Nolan et al., 2017). This example highlights the importance that plant hormones can have as major integrators of environmental stress and nutrient status. Hunger games: nutrient and energy signaling Over recent years it has become clear that plants integrate energy/nutrient status to regulate growth and stress responses using antagonistic signaling pathways mediated by the evolutionarily conserved protein kinases TOR (TARGET OF RAPAMYCIN) and SnRK1 (Snf1-RELATED PROTEIN KINASE1) (Robaglia et al., 2012; Broeckx et al., 2016; Baena-González and Hanson, 2017). The central role of these kinases in energy metabolism is underlined by their wide conservation in the eukaryotes, from yeast and animals to plants and fungi (Roustan et al., 2016). SnRK1 is activated by low-energy conditions, such as those that may occur during stress exposure, to trigger catabolism and repress growth. Notably, SnRK1 can be activated by the inhibition of photosynthesis with the inhibitor DCMU, and can be inhibited by the addition of sugars. SnRK1 directly targets metabolic and regulatory enzymes in the cytosol, and also affects gene expression via the phosphorylation of transcription factors such as BZIP63 (Mair et al., 2015; Nukarinen et al., 2016). In contrast, TOR promotes cell growth and proliferation in response to light, sugars, and growth-promoting hormones through the phosphorylation of target proteins (recently reviewed by Schepetilnikov and Ryabova, 2018). Over the past 10 years a growing number of TORC client proteins and downstream effectors have been firmly identified in plants, including the S6 kinase, E2F, and the brassinosteroid pathway. A very recent study has shown that TOR can also phosphorylate the ABA receptor PYL to prevent activation of the ABA-signaling effector kinase SnRK2 in non-stressed plants (Wang et al., 2018). In turn, under stress conditions, ABA is able to activate SnRK2, which then phosphorylates a member of the TOR complex RAPTOR, which triggers complex dissociation and TOR inactivation. This antagonistic signaling loop is an excellent example of how plants are able make the decision between growth and stress acclimation. Interestingly, both TOR and SnRK1 have been implicated in the regulation of chloroplast function (Dong et al., 2015; Dobrenel et al., 2016; Nukarinen et al., 2016; Sun et al., 2016; Imamura et al., 2018). It all comes down to light: chloroplasts at the centre of stress perception and regulation Chloroplasts are one of the powerhouses for plant productivity, but photosynthesis is highly sensitive to light, CO2 levels, and plant metabolic capacity. Excess light, or limitation in CO2 supply or metabolic capacity, during abiotic stress exposure rapidly leads to over-excitation and reduction of the photosynthetic electron transport chain. Over-excitation is potentially highly dangerous for the plant because it can lead to the production of ROS such as 1O2 and H2O2 that can irreversibly damage proteins, membranes and DNA. However, changes in chloroplast redox status during overexcitation act as a signal that leads to the rapid activation of energy-dissipating mechanisms, changes in chloroplast genome expression, and over the longer term to changes in chloroplast protein composition and position to allow acclimation. Importantly, chloroplast stress triggers acclimation at the cellular level as well as the organellar level, and as the severity of stress increases can lead to growth inhibition and eventually programmed cell death (Laloi and Havaux, 2015). The majority of chloroplast proteins are encoded in the nuclear genome. Remodelling of the chloroplast proteome during abiotic stress acclimation therefore requires signaling from the nucleus to the chloroplast (anterograde signaling), and from the chloroplast to the nucleus (retrograde signaling). An overview of chloroplast proteome remodelling, with a focus on stress-regulated import of proteins, nuclear control of the chloroplast genome and protein turnover within the chloroplast is reviewed in this special issue (Watson et al., 2018). Stress-induced retrograde signaling from the chloroplast is also considered from a different perspective by Crawford et al. (2018). In particular, these authors discuss how the stress-induced down-regulation of photosynthesis and respiration in the mitochondria can lead to a reduction in the supply of energy available for cellular stress acclimation. They propose a new hypothesis for the integration of different organellar retrograde signals in the nucleus to coordinate transcriptional responses that regulate the allocation of energy to either growth or stress acclimation. Notably, and in relation to this hypothesis, recent work indicates that chloroplast-generated H2O2 acts as a retrograde signal that is directly transferred from the chloroplast to the nucleus, avoiding the cytosol, to drive a transcriptional response (Exposito-Rodriguez et al., 2017). Stress can also lead to transcriptional reprogramming within the chloroplast, and the signaling nucleotides guanosine tetra- and penta-phosphate [or (p)ppGpp] potentially play a major role (Field, 2018). Indeed, (p)ppGpp is known to accumulate in response to a wide range of different abiotic stresses, and both in vitro and in vivo studies show that (p)ppGpp accumulation inhibits chloroplast transcription and affects chloroplast function. These findings and other recent advances in our understanding of (p)ppGpp metabolism in plants and algae are reviewed by Field (2018). While light plays an obvious role in the production of photosynthates and energy, a perhaps less intuitive role is in the regulation of biomass partitioning and plant architecture in response to resource availability, which can occur in a phytochrome B (PHYB) dependent manner (Arsovski et al., 2018). The function of phytochromes as regulators of carbon supply, metabolic status and biomass production has been recently proposed (Yang et al., 2016), and together with the PHYB- and light-dependent development of stomata (Casson and Hetherington, 2014) emphasizes the close connection between light perception and photosynthetic metabolism beyond photosynthetic electron transport. PHYB was also recently shown to act as a temperature sensor in plants. PHYB activity decreases with increasing temperature in a light-dependent manner (Legris et al., 2016), to allow the optimization of growth and biomass production under different environmental conditions. Furthermore, PHYB has been demonstrated to uncouple growth and defense pathways through the relief of transcriptional repression, thereby providing a direct link between light, plant growth and defense signaling pathways (Campos et al., 2016; Cerrudo et al., 2017). The trade-off between growth and defense: a balancing act? In light of the diverse molecular mechanisms that regulate growth and abiotic stress acclimation the question arises as to whether the induction of stress tolerance always leads to growth penalties, or whether we can get something for nothing. It is commonly thought that constitutive stress tolerance comes at a cost to the organism, and this has been extensively reviewed for disease resistance traits (Heil, 2014; Heil and Baldwin, 2002). Early examples of engineered constitutive abiotic stress tolerances have often led to growth penalties under benign growth conditions (Kasuga et al., 1999; Haake et al., 2002). Another example is the Physcomitrella patens ppabi1a/b double mutant, where ABA signaling is constitutively active, which is stress resistant but also shows very severe growth defects (Komatsu et al., 2013). However, there are now many indications that the cost need not always be so high. C24, an Arabidopsis ecotype from the Iberian peninsula, is resistant to ROS, heat and drought stress yet shows similar productivity to less-tolerant ecotypes. These features have led to research into the genetic and molecular basis of the growth/resistance equilibrium in C24, and is reviewed in this issue by Bechtold et al. (2018). The hope is that research in such a tractable model species may lead to the rapid development of new strategies for conferring stress resistance to crop plants without penalties. The basis of C24 stress resistance is likely to be complex and multigenic. However, even the overexpression of a single transcription factor gene, such as Heat Shock Transcription FactorA1b, can lead to penalty-less increases in abiotic stress resistance (Bechtold et al., 2013), and other positive examples utilizing single-gene manipulations are highlighted in Bechtold et al. (2018). Intriguingly, the molecular basis of HSFA1b stress resistance appears to be in its ability to regulate the expression of a large hierarchical network of stress and development genes (Albihlal et al., 2018), suggesting the HSFA1b could be a master regulator of the switch between growth and abiotic stress defenses. It will also be fascinating to discover how such ‘penalty-less’ improvements in stress tolerance are able to bypass SnRK1/TOR-mediated growth control. Future directions Research into plant responses to environmental stress and the application of this knowledge to improve productivity under non-optimal growing conditions is becoming ever more important. Over recent years dramatic progress has been made, and the molecular mechanisms for many stress response pathways revealed. Identification of the cellular hubs that integrate these diverse stress acclimation mechanisms, and the regulatory logic behind the plant’s decision-making processes, are now emerging themes in the field. Over coming years further research in these directions has the potential to lead to a more unified view of plant growth and abiotic stress resistance that could be applied for the rational improvement of crop plants. Acknowledgements This editorial covers a topic that was part of a stimulating two-day session held at the Society for Experimental Biology meeting in Gothenburg, Sweden in 2017, and which forms the basis for the reviews and research articles in this special issue. References Achard P , Renou JP , Berthomé R , Harberd NP , Genschik P . 2008 . Plant DELLAs restrain growth and promote survival of adversity by reducing the levels of reactive oxygen species . Current Biology 18 , 656 – 660 . Google Scholar CrossRef Search ADS Albihlal WS , Chernukhin I , Blein T , Persad R , Obomighie I , Crespi M , Bechtold U , Mullineaux P . 2018 . Arabidopsis heat shock transcription factorA1b regulates multiple developmental genes under growth and stress conditions . Journal of Experimental Botany 69 , 2847 – 2862 . Arsovski AA , Zemke JE , Haagen BD , Kim S-H , Nemhauser JL . 2018 . Phytochrome B regulates resource allocation in Brassica rapa . Journal of Experimental Botany , 69 , 2837 – 2846 . Baena-González E , Hanson J . 2017 . Shaping plant development through the SnRK1-TOR metabolic regulators . Current Opinion in Plant Biology 35 , 152 – 157 . Google Scholar CrossRef Search ADS Balzergue C , Dartevelle T , Godon C , et al. 2017 . Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation . Nature Communications 8 , 15300 . Google Scholar CrossRef Search ADS Bechtold U , Albihlal WS , Lawson T , et al. 2013 . Arabidopsis HEAT SHOCK TRANSCRIPTION FACTORA1b overexpression enhances water productivity, resistance to drought, and infection . Journal of Experimental Botany 64 , 3467 – 3481 . Google Scholar CrossRef Search ADS Bechtold U , Ferguson JN , Mullineaux PM . 2018 . To defend or to grow: lessons from Arabidopsis C24 . Journal of Experimental Botany 69 , 2809 – 2821 . Broeckx T , Hulsmans S , Rolland F . 2016 . The plant energy sensor: evolutionary conservation and divergence of SnRK1 structure, regulation, and function . Journal of Experimental Botany 67 , 6215 – 6252 . Google Scholar CrossRef Search ADS Campos ML , Yoshida Y , Major IT , et al. 2016 . Rewiring of jasmonate and phytochrome B signalling uncouples plant growth-defense tradeoffs . Nature Communications 7 , 12570 . Google Scholar CrossRef Search ADS Casson SA , Hetherington AM . 2014 . Phytochrome B Is required for light-mediated systemic control of stomatal development . Current Biology 24 , 1216 – 1221 . Google Scholar CrossRef Search ADS Cerrudo I , Caliri-Ortiz ME , Keller MM , Degano ME , Demkura PV , Ballaré CL . 2017 . Exploring growth-defence trade-offs in Arabidopsis: phytochrome B inactivation requires JAZ10 to suppress plant immunity but not to trigger shade-avoidance responses . Plant, Cell & Environment 40 , 635 – 644 . Google Scholar CrossRef Search ADS Chapin FS III . 1991 . Integrated responses of plants to stress: a centralized system of physiological responses . BioScience 41 , 29 – 36 . Google Scholar CrossRef Search ADS Cramer GR , Urano K , Delrot S , Pezzotti M , Shinozaki K . 2011 . Effects of abiotic stress on plants: a systems biology perspective . BMC Plant Biology 11 , 163 . Google Scholar CrossRef Search ADS Crawford T , Lehotai N , Strand A . 2018 . The role of retrograde signals during plant stress responses . Journal of Experimental Botany 69 , 2783 – 2795 . Dietrich D . 2018 . Hydrotropism: how roots search for water . Journal of Experimental Botany 69 , 2759 – 2771 . Dietrich D , Pang L , Kobayashi A , et al. 2017 . Root hydrotropism is controlled via a cortex-specific growth mechanism . Nature Plants 3 , 17057 . Google Scholar CrossRef Search ADS Dobrenel T , Mancera-Martínez E , Forzani C , et al. 2016 . The Arabidopsis TOR kinase specifically regulates the expression of nuclear genes coding for plastidic ribosomal proteins and the phosphorylation of the cytosolic ribosomal protein S6 . Frontiers in Plant Science 7 , 1611 . Google Scholar CrossRef Search ADS Dong P , Xiong F , Que Y , Wang K , Yu L , Li Z , Ren M . 2015 . Expression profiling and functional analysis reveals that TOR is a key player in regulating photosynthesis and phytohormone signaling pathways in Arabidopsis . Frontiers in Plant Science 6 , 677 . Dubois M , Claeys H , Van den Broeck L , Inzé D . 2017 . Time of day determines Arabidopsis transcriptome and growth dynamics under mild drought . Plant, Cell & Environment 40 , 180 – 189 . Google Scholar CrossRef Search ADS Eapen D , Martínez-Guadarrama J , Hernández-Bruno O , Flores L , Nieto-Sotelo J , Cassab GI . 2017 . Synergy between root hydrotropic response and root biomass in maize (Zea mays L.) enhances drought avoidance . Plant Science 265 , 87 – 99 . Google Scholar CrossRef Search ADS Exposito-Rodriguez M , Laissue PP , Yvon-Durocher G , Smirnoff N , Mullineaux PM . 2017 . Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism . Nature Communications 8 , 49 . Google Scholar CrossRef Search ADS Field B . 2018 . Green magic: regulation of the chloroplast stress response by (p)ppGpp in plants and algae . Journal of Experimental Botany 69 , 2797 – 2807 . Godfray HC , Beddington JR , Crute IR , Haddad L , Lawrence D , Muir JF , Pretty J , Robinson S , Thomas SM , Toulmin C . 2010 . Food security: the challenge of feeding 9 billion people . Science 327 , 812 – 818 . Google Scholar CrossRef Search ADS Haake V , Cook D , Riechmann JL , Pineda O , Thomashow MF , Zhang JZ . 2002 . Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis . Plant Physiology 130 , 639 – 648 . Google Scholar CrossRef Search ADS Heil M . 2014 . Trade-offs associated with induced resistance . In: Walters D , Newton A , Lyon G , eds. Induced resistance for plant defense . Oxford : Wiley , 171 – 192 . Heil M , Baldwin IT . 2002 . Fitness costs of induced resistance: emerging experimental support for a slippery concept . Trends in Plant Science 7 , 61 – 67 . Google Scholar CrossRef Search ADS Imamura S , Nomura Y , Takemura T , Pancha I , Taki K , Toguchi K , Tozawa Y , Tanaka K . 2018 . The checkpoint kinase TOR (target of rapamycin) regulates expression of a nuclear-encoded chloroplast RelA-SpoT homolog (RSH) and modulates chloroplast ribosomal RNA synthesis in a unicellular red alga . The Plant Journal 94 , 327 – 339 . Google Scholar CrossRef Search ADS Kasuga M , Liu Q , Miura S , Yamaguchi-Shinozaki K , Shinozaki K . 1999 . Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor . Nature Biotechnology 17 , 287 – 291 . Google Scholar CrossRef Search ADS Kobayashi A , Takahashi A , Kakimoto Y , Miyazawa Y , Fujii N , Higashitani A , Takahashi H . 2007 . A gene essential for hydrotropism in roots . Proceedings of the National Academy of Sciences, USA 104 , 4724 – 4729 . Google Scholar CrossRef Search ADS Komatsu K , Suzuki N , Kuwamura M , et al. 2013 . Group A PP2Cs evolved in land plants as key regulators of intrinsic desiccation tolerance . Nature Communications 4 , 2219 . Laloi C , Havaux M . 2015 . Key players of singlet oxygen-induced cell death in plants . Frontiers in Plant Science 6 , 39 . Google Scholar CrossRef Search ADS Legris M , Klose C , Burgie ES , Rojas CC , Neme M , Hiltbrunner A , Wigge PA , Schäfer E , Vierstra RD , Casal JJ . 2016 . Phytochrome B integrates light and temperature signals in Arabidopsis . Science 354 , 897 – 900 . Google Scholar CrossRef Search ADS Mair A , Pedrotti L , Wurzinger B , et al. 2015 . SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants . eLife 4 , e05828 . Miyazawa Y , Sakashita T , Funayama T , et al. 2008 . Effects of locally targeted heavy-ion and laser microbeam on root hydrotropism in Arabidopsis thaliana . Journal of Radiation Research 49 , 373 – 379 . Google Scholar CrossRef Search ADS Moriwaki T , Miyazawa Y , Fujii N , Takahashi H . 2012 . Light and abscisic acid signalling are integrated by MIZ1 gene expression and regulate hydrotropic response in roots of Arabidopsis thaliana . Plant, Cell & Environment 35 , 1359 – 1368 . Google Scholar CrossRef Search ADS Moriwaki T , Miyazawa Y , Kobayashi A , Uchida M , Watanabe C , Fujii N , Takahashi H . 2011 . Hormonal regulation of lateral root development in Arabidopsis modulated by MIZ1 and requirement of GNOM activity for MIZ1 function . Plant Physiology 157 , 1209 – 1220 . Google Scholar CrossRef Search ADS Nolan T , Chen J , Yin Y . 2017 . Cross-talk of Brassinosteroid signaling in controlling growth and stress responses . The Biochemical Journal 474 , 2641 – 2661 . Google Scholar CrossRef Search ADS Nukarinen E , Nägele T , Pedrotti L , et al. 2016 . Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation . Scientific Reports 6 , 31697 . Google Scholar CrossRef Search ADS Plumb W , Townsend A , Rasool B , Alomrani S , Razak N , Ruban A , Foyer C . 2018 . Ascorbate-mediated regulation of growth, photoprotection, and photoinhibition in Arabidopsis thaliana . Journal of Experimental Botany 69 , 2823 – 2835 . Robaglia C , Thomas M , Meyer C . 2012 . Sensing nutrient and energy status by SnRK1 and TOR kinases . Current Opinion in Plant Biology 15 , 301 – 307 . Google Scholar CrossRef Search ADS Roustan V , Jain A , Teige M , Ebersberger I , Weckwerth W . 2016 . An evolutionary perspective of AMPK-TOR signaling in the three domains of life . Journal of Experimental Botany 67 , 3897 – 3907 . Google Scholar CrossRef Search ADS Saucedo M , Ponce G , Campos ME , Eapen D , García E , Luján R , Sánchez Y , Cassab GI . 2012 . An altered hydrotropic response (ahr1) mutant of Arabidopsis recovers root hydrotropism with cytokinin . Journal of Experimental Botany 63 , 3587 – 3601 . Google Scholar CrossRef Search ADS Schepetilnikov M , Ryabova LA . 2018 . Recent discoveries on the role of TOR (Target of Rapamycin) signaling in translation in plants . Plant Physiology 176 , 1095 – 1105 . Google Scholar CrossRef Search ADS Sun L , Yu Y , Hu W , Min Q , Kang H , Li Y , Hong Y , Wang X , Hong Y . 2016 . Ribosomal protein S6 kinase1 coordinates with TOR-Raptor2 to regulate thylakoid membrane biosynthesis in rice . Biochimica et Biophysica Acta 1861 , 639 – 649 . Google Scholar CrossRef Search ADS Verma V , Ravindran P , Kumar PP . 2016 . Plant hormone-mediated regulation of stress responses . BMC Plant Biology 16 , 86 . Google Scholar CrossRef Search ADS Wang H , Wang H , Shao H , Tang X . 2016 . Recent advances in utilizing transcription factors to improve plant abiotic stress tolerance by transgenic technology . Frontiers in Plant Science 7 , 67 . Wang P , Zhao Y , Li Z , et al. 2018 . Reciprocal regulation of the TOR kinase and ABA receptor balances plant growth and stress response . Molecular Cell 69 , 100 – 112.e6 . Google Scholar CrossRef Search ADS Watson SJ , Sowden RG , Jarvis P . 2018 . Abiotic stress-induced chloroplast proteome remodelling: a mechanistic overview . Journal of Experimental Botany 69 , 2773 – 2781 . Xie Y , Tan H , Ma Z , Huang J . 2016 . DELLA proteins promote anthocyanin biosynthesis via sequestering MYBL2 and JAZ suppressors of the MYB/bHLH/WD40 complex in Arabidopsis thaliana . Molecular Plant 9 , 711 – 721 . Google Scholar CrossRef Search ADS Yang D , Seaton DD , Krahmer J , Halliday KJ . 2016 . Photoreceptor effects on plant biomass, resource allocation, and metabolic state . Proceedings of the National Academy of Sciences, USA 113 , 7667 – 7672 . Google Scholar CrossRef Search ADS Zhu JK . 2016 . Abiotic stress signaling and responses in plants . Cell 167 , 313 – 324 . Google Scholar CrossRef Search ADS © The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Experimental Biology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal of Experimental Botany – Oxford University Press
Published: May 19, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera