Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Molecular control of the identity of tissue-resident macrophages

Molecular control of the identity of tissue-resident macrophages Macrophages are present in virtually almost all tissues, exhibiting highly heterogeneous phenotypes as a consequence of adaptation to local tissue environments. Tissue-resident macrophages perform specialized functions that are essential for the maintenance of tissue homeostasis, and abnormalities of their functions are linked to various pathologies. Recent advances have shown that tissue-specific transcriptional programs are responsible for functional specialization of macrophages in different tissues. Here, I discuss the molecular basis of tissue-resident macrophage specialization and how it is regulated by tissue environmental cues. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Immunology Oxford University Press

Molecular control of the identity of tissue-resident macrophages

Okabe, Yasutaka
International Immunology , Volume 30 (11): 7 – Feb 23, 2018
Download PDF
8 pages

Loading next page...
 
/lp/ou_press/molecular-control-of-the-identity-of-tissue-resident-macrophages-uMppHMROgM
Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of The Japanese Society for Immunology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
ISSN
0953-8178
eISSN
1460-2377
DOI
10.1093/intimm/dxy019
Publisher site
See Article on Publisher Site

Abstract

Macrophages are present in virtually almost all tissues, exhibiting highly heterogeneous phenotypes as a consequence of adaptation to local tissue environments. Tissue-resident macrophages perform specialized functions that are essential for the maintenance of tissue homeostasis, and abnormalities of their functions are linked to various pathologies. Recent advances have shown that tissue-specific transcriptional programs are responsible for functional specialization of macrophages in different tissues. Here, I discuss the molecular basis of tissue-resident macrophage specialization and how it is regulated by tissue environmental cues.

Journal

International Immunology – Oxford University Press

Published: Feb 23, 2018

Keywords: differentiation; polarization; tissue homeostasis

References

  • Metchnikoff and the phagocytosis theory
    Tauber, A. I
  • Thematic review series: the immune system and atherogenesis. Recent insights into the biology of macrophage scavenger receptors
    Greaves, D. R.; Gordon, S
  • Pattern recognition receptors and inflammation
    Takeuchi, O.; Akira, S
  • Mechanisms of phagocytosis in macrophages
    Aderem, A.; Underhill, D. M
  • Macrophages in tissue repair, regeneration, and fibrosis
    Wynn, T. A.; Vannella, K. M
  • Macrophage biology in development, homeostasis and disease
    Wynn, T. A.; Chawla, A.; Pollard, J. W
  • Macrophages: development and tissue specialization
    Varol, C.; Mildner, A.; Jung, S
  • Tissue-resident macrophages
    Davies, L. C.; Jenkins, S. J.; Allen, J. E.; Taylor, P. R
  • Macrophage heterogeneity in tissues: phenotypic diversity and functions
    Gordon, S.; Plüddemann, A.; Martinez Estrada, F
  • The origin and kinetics of mononuclear phagocytes
    van Furth, R.; Cohn, Z. A
  • Homeostasis in the mononuclear phagocyte system
    Jenkins, S. J.; Hume, D. A
  • Tissue-resident macrophage ontogeny and homeostasis
    Ginhoux, F.; Guilliams, M
  • The development and maintenance of resident macrophages
    Perdiguero, E. G.; Geissmann, F
  • Beyond stem cells: self-renewal of differentiated macrophages
    Sieweke, M. H.; Allen, J. E
  • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    Yona, S.; Kim, K. W.; Wolf, Y.
  • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    Schulz, C.; Gomez Perdiguero, E.; Chorro, L.
  • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    Hashimoto, D.; Chow, A.; Noizat, C.
  • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    Ginhoux, F.; Greter, M.; Leboeuf, M.
  • Tissue biology perspective on macrophages
    Okabe, Y.; Medzhitov, R
  • Osteoclast differentiation and activation
    Boyle, W. J.; Simonet, W. S.; Lacey, D. L
  • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    Odegaard, J. I.; Chawla, A
  • Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation
    Phan, T. G.; Green, J. A.; Gray, E. E.; Xu, Y.; Cyster, J. G
  • Synaptic pruning by microglia is necessary for normal brain development
    Paolicelli, R. C.; Bolasco, G.; Pagani, F.
  • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    Gautier, E. L.; Shay, T.; Miller, J.
  • Tissue-specific signals control reversible program of localization and functional polarization of macrophages
    Okabe, Y.; Medzhitov, R
  • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    Lavin, Y.; Winter, D.; Blecher-Gonen, R.
  • CSF-1 receptor signaling in myeloid cells
    Stanley, E. R.; Chitu, V
  • Trophic macrophages in development and disease
    Pollard, J. W
  • Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
    Davies, L. C.; Rosas, M.; Jenkins, S. J.
  • IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    Wang, Y.; Szretter, K. J.; Vermi, W.
  • The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor
    Zhang, D. E.; Hetherington, C. J.; Chen, H. M.; Tenen, D. G
  • Molecular control of activation and priming in macrophages
    Glass, C. K.; Natoli, G
  • CCAAT/enhancer-binding proteins: structure, function and regulation
    Ramji, D. P.; Foka, P
  • Stepwise reprogramming of B cells into macrophages
    Xie, H.; Ye, M.; Feng, R.; Graf, T
  • Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages
    Cain, D. W.; O’Koren, E. G.; Kan, M. J.
  • Identification of an atypical monocyte and committed progenitor involved in fibrosis
    Satoh, T.; Nakagawa, K.; Sugihara, F.
  • MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages
    Aziz, A.; Soucie, E.; Sarrazin, S.; Sieweke, M. H
  • Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
    Soucie, E. L.; Weng, Z.; Geirsdóttir, L.
  • The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
    Amit, I.; Winter, D. R.; Jung, S
  • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    Gosselin, D.; Link, V. M.; Romanoski, C. E.
  • Revisiting the sphingolipid rheostat: evolving concepts in cancer therapy
    Newton, J.; Lima, S.; Maceyka, M.; Spiegel, S
  • Tissue-resident macrophages: then and now
    Davies, L. C.; Taylor, P. R
  • Two physically, functionally, and developmentally distinct peritoneal macrophage subsets
    Ghosn, E. E.; Cassado, A. A.; Govoni, G. R.
  • MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes
    Kim, K. W.; Williams, J. W.; Wang, Y. T.
  • The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal
    Rosas, M.; Davies, L. C.; Giles, P. J.
  • Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
    Gautier, E. L.; Ivanov, S.; Williams, J. W.
  • Epigenetic regulation of the alternatively activated macrophage phenotype
    Ishii, M.; Wen, H.; Corsa, C. A.
  • Milky spots in the mouse omentum may play an important role in the origin of peritoneal macrophages
    Wijffels, J. F.; Hendrickx, R. J.; Steenbergen, J. J.; Eestermans, I. L.; Beelen, R. H
  • Immunological functions of the omentum
    Meza-Perez, S.; Randall, T. D
  • Omental lymphoid organ as a source of macrophage colony stimulating activity in peritoneal cavity
    Ratajczak, M. Z.; Jaskulski, D.; Pojda, Z.; Wiktor-Jedrzejczak, W
  • Effect of omentectomy on peritoneal defence mechanisms in rats
    Agalar, F.; Sayek, I.; Cakmakçi, M.; Hasçelik, G.; Abbasoglu, O
  • Review of the macrophage disappearance reaction
    Barth, M. W.; Hendrzak, J. A.; Melnicoff, M. J.; Morahan, P. S
  • A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair
    Wang, J.; Kubes, P
  • Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques
    Kotani, M.; Kikuta, J.; Klauschen, F.
  • RANKL-RANK signaling in osteoclastogenesis and bone disease
    Wada, T.; Nakashima, T.; Hiroshi, N.; Penninger, J. M
  • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    Takayanagi, H.; Kim, S.; Koga, T.
  • Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation
    Epelman, S.; Lavine, K. J.; Beaudin, A. E.
  • Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
    Kohyama, M.; Ise, W.; Edelson, B. T.
  • Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
    Haldar, M.; Kohyama, M.; So, A. Y.
  • Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
    Guilliams, M.; De Kleer, I.; Henri, S.
  • Alveolar macrophages: plasticity in a tissue-specific context
    Hussell, T.; Bell, T. J
  • Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
    Dranoff, G.; Crawford, A. D.; Sadelain, M.
  • The M1 and M2 paradigm of macrophage activation: time for reassessment
    Martinez, F. O.; Gordon, S
  • Alternative activation of macrophages: mechanism and functions
    Gordon, S.; Martinez, F. O
  • Macrophage plasticity and polarization: in vivo veritas
    Sica, A.; Mantovani, A
  • Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
    Schneider, C.; Nobs, S. P.; Kurrer, M.; Rehrauer, H.; Thiele, C.; Kopf, M
  • Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function
    Nakamura, A.; Ebina-Shibuya, R.; Itoh-Nakadai, A.
  • The cytokine TGF-β promotes the development and homeostasis of alveolar macrophages
    Yu, X.; Buttgereit, A.; Lelios, I.
  • Neuron-microglia interactions in mental health disorders: ‘for better, and for worse’
    Wohleb, E. S
  • Origin and differentiation of microglia
    Ginhoux, F.; Lim, S.; Hoeffel, G.; Low, D.; Huber, T
  • Control of microglial neurotoxicity by the fractalkine receptor
    Cardona, A. E.; Pioro, E. P.; Sasse, M. E.
  • Identification of a unique TGF-β-dependent molecular and functional signature in microglia
    Butovsky, O.; Jedrychowski, M. P.; Moore, C. S.
  • Sall1 is a transcriptional regulator defining microglia identity and function
    Buttgereit, A.; Lelios, I.; Yu, X.