Long-term Remission of Malignant Brain Tumors after Intracranial Infection: A Report of Four Cases

Long-term Remission of Malignant Brain Tumors after Intracranial Infection: A Report of Four Cases AbstractOBJECTIVE:This report describes four patients with malignant brain tumors in whom regression or cure seems to be related to infection with bacteriaMETHODS:An analysis of the four clinical cases reported and a review of the literature produced a comprehensive body of both experimental and clinical data concerning the antineoplastic properties of bacteria.RESULTS:Although direct oncolytic effects from bacteria have been suggested, immune adjuvant responses to tumor suppression are emphasized. In one of our patients, infiltration of numerous granulocytes and lymphocytes into the tumor at the time of initial surgery was observed, suggesting that a spontaneous immune reaction had begun. Also, in two other patients, tumor aggression occurred in association with a bacterial process that was not in direct contact with the tumor. In three of the cases described, Enterobacter aerogenes was recovered from the microbial cultures. Whether the presence of this organism was coincidental or whether this organism plays an important role in tumor defense is not known; however, a specific cross-reactive immunological attack to the tumor is suggested.CONCLUSION:The case histories presented in conjunction with the relevant literature reviewed support the concept that microbial infections may influence immune responses in brain tumor defense. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Long-term Remission of Malignant Brain Tumors after Intracranial Infection: A Report of Four Cases

Long-term Remission of Malignant Brain Tumors after Intracranial Infection: A Report of Four Cases

636 Bourgeois et al. which w ould have required careful typ­ thors' reco m m en d atio n for prophylactic had HSV 1 m eningoencephalitis at the ing of the virus, p erhap s at a deoxyribo­ acyclovir is difficult to justify on the age of 16 months. This was docum ented nucleic acid sequ en ce level. Nonethe­ basis of one case. H ow ever, this case as best as could be done. Subsequently, less, the m ost likely explanation is does serve as a w arn in g to n e u ro su r­ 6 years later, the patient u n derw ent a reactivation of the sam e virus, and this geons to consider the possibility of re­ left a m y g d alo h ip p o ca m p ecto m y for in­ should be considered by neurosurgeons currence of H SV encephalitis in a p a ­ tractable epilepsy and had a clinical p ic­ w ith sim ilar cases. tient with a history of such an illness. ture consistent with a second course of The authors failed to d o cu m en t w heth er C o rey Raffel HSV 1 encephalitis. Again, this was d o c­ this w as reactivation of the sam e virus, R ochester, Minnesota umented as best as possible. The a u ­ the lung with p ostop erative wound in­ Long-term Remission of Malignant Brain fection, and a significant number of in­ fections w ere found in instances of Tumors after Intracranial Infection: sp o n tan eo u sly regressing tumors, par­ ticularly in skin, lung, and bone (26,32, A Report of Four Cases 38, 42). Few reports, how ever, describe a relationship b etw een tum or growth and microbial activity in the central nervous system (CNS). M oreover, oncolytic ef­ Alfred P. Bowles, Jr., M.D., Eddie Perkins, M.S. fects observed from infections are Department of Neurosurgery, The University of Mississippi Medical Center, poorly defined. This report describes jackson, Mississippi four patients with m alignant brain tu­ m ors in w h o m regression or cure seems to be tem p orally related to an infectious process by bacteria. Direct oncolytic...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199903000-00110
Publisher site
See Article on Publisher Site

Abstract

AbstractOBJECTIVE:This report describes four patients with malignant brain tumors in whom regression or cure seems to be related to infection with bacteriaMETHODS:An analysis of the four clinical cases reported and a review of the literature produced a comprehensive body of both experimental and clinical data concerning the antineoplastic properties of bacteria.RESULTS:Although direct oncolytic effects from bacteria have been suggested, immune adjuvant responses to tumor suppression are emphasized. In one of our patients, infiltration of numerous granulocytes and lymphocytes into the tumor at the time of initial surgery was observed, suggesting that a spontaneous immune reaction had begun. Also, in two other patients, tumor aggression occurred in association with a bacterial process that was not in direct contact with the tumor. In three of the cases described, Enterobacter aerogenes was recovered from the microbial cultures. Whether the presence of this organism was coincidental or whether this organism plays an important role in tumor defense is not known; however, a specific cross-reactive immunological attack to the tumor is suggested.CONCLUSION:The case histories presented in conjunction with the relevant literature reviewed support the concept that microbial infections may influence immune responses in brain tumor defense.

Journal

NeurosurgeryOxford University Press

Published: Mar 1, 1999

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