Abstract In a cohort of HIV-infected individuals and age and sex-matched HIV-uninfected comparators, we assessed soluble (s)CD14, sCD163, interleukin (IL)-6, intestinal fatty acid binding protein (IFAPB) and high-sensitivity C-reactive protein (hs-CRP). The median age was 51 years; and among HIV+, median ART duration was 7 years, median CD4 T-cell count was 433, and 86% had an undetectable viral load. Although HIV+ had higher sCD14, IFABP and hs-CRP, we found evidence of interaction by sex, such that HIV+ women had greater differences versus HIV- compared to men. In models restricted to HIV+, women had higher levels of all five biomarkers than men. HIV, inflammation, gut permeability, Uganda, sub-Saharan Africa, sex, women © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: firstname.lastname@example.org. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)
The Journal of Infectious Diseases – Oxford University Press
Published: Apr 28, 2018
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