Review Article Drug review: Pazopanib We present the results of clinical trials as well as the pharmacological action of pazopanib, with the aim of evaluating its current state by examining various associated issues. Miyamoto, S., Kakutani, S., Sato, Y., et al. Jpn J Clin Oncol 2018 48:6 503–513, 10.1093/jjco/hyy053 Original Articles Dermatology Prevalence and molecular characteristics of DNA mismatch repair protein-deficient sebaceous neoplasms and keratoacanthomas in a Japanese hospital-based population The screening of Muir-Torre syndrome-associated cutaneous neoplasms for identifying patients with Lynch syndrome may be limited. Mismatch repair protein deficiency in the sebaceous neoplasms was almost caused by somatic alterations. Kuwabara, K., Suzuki, O., Chika, N., et al. Jpn J Clin Oncol 2018 48:6 514–521, 10.1093/jjco/hyy055 Gynecology Liquid-based cytology versus conventional cytology for detection of uterine cervical lesions: a prospective observational study From our prospective observational study, liquid-based and conventional cytology have similar diagnostic performances. Liquid-based cytology can be a useful option for cervical cancer screening. Nishio, H., Iwata, T., Nomura, H., et al. Jpn J Clin Oncol 2018 48:6 522–528, 10.1093/jjco/hyy050 Head & Neck Prognostic impact of incisional or excisional biopsy of cervical lymph node metastases of solid tumors The effect of an incisional biopsy for a metastatic cervical solid tumor on patients’ survival was no worse than that of an excisional biopsy, despite the latter being theoretically preferable. Shinohara, S., Takebayashi, S., Kikuchi, M., et al. Jpn J Clin Oncol 2018 48:6 529–534, 10.1093/jjco/hyy056 Hepato-biliary and Pancreatic Medicine Efficacy and safety comparison of nabpaclitaxel plus S-1 and gemcitabine plus S-1 as first-line chemotherapy for metastatic pancreatic cancer For metastatic pancreatic cancer, Nabpaclitaxel & S-1 provided more benefits (time to progression 7.1 vs. 3.6 months; overall survival 10.2 vs. 6 months) compared with Gemcitabine & S-1. Xu, Y., Guo, X., Fan, Y., et al. Jpn J Clin Oncol 2018 48:6 535–541, 10.1093/jjco/hyy063 Palliative and Supportive Care A randomized, double-blind, non-inferiority study of hydromorphone hydrochloride immediate-release tablets versus oxycodone hydrochloride immediate-release powder for cancer pain: efficacy and safety in Japanese cancer patients The non-inferiority of hydromorphone compared with oxycodone for the treatment of cancer pain was confirmed in 183 Japanese cancer patients. Hydromorphone and oxycodone had similar efficacy and safety profiles. Inoue, S., Saito, Y., Tsuneto, S., et al. Jpn J Clin Oncol 2018 48:6 542–547, 10.1093/jjco/hyy038 Radiation Oncology Feasibility of split-course stereotactic ablative radiotherapy for oligometastases Split-course stereotactic ablative radiotherapy (SABR) appeared to achieve favorable toxicity profiles and local control outcomes comparable with those of continuous SABR in the patients with oligometastases. Paik, E K., Kim, M-S., Seo, Y-S., et al. Jpn J Clin Oncol 2018 48:6 548–554, 10.1093/jjco/hyy062 Palliative radiotherapy for breast cancer patients with skin invasion: a multi-institutional prospective observational study Palliative radiotherapy for skin invasion in patients with breast cancer might be effective, especially for the relief of bleeding/discharge and offensive odor. Nakamura, N., Kawamori, J., Takahashi, O., et al. Jpn J Clin Oncol 2018 48:6 555–558, 10.1093/jjco/hyy054 Translational Research Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study We confirmed the feasibility of NGS-based amplicon sequencing using biopsy samples, making the basis for nationwide genome screening for cancer patients using biopsy samples. Naito, Y., Takahashi, H., Shitara, K., et al. Jpn J Clin Oncol 2018 48:6 559–564, 10.1093/jjco/hyy052 Urology Outcomes of active surveillance of clinical stage I non-seminomatous germ cell tumors: sub-analysis of the multi-institutional nationwide case series of the Japanese Urological Association The only significant risk factor of recurrence was the existence of embryonal carcinoma elements in stage I non-seminomatous germ cell tumors. Shinoda, Y., Matsui, Y., Fujimoto, H., et al. Jpn J Clin Oncol 2018 48:6 565–569, 10.1093/jjco/hyy051 Two years of bicalutamide monotherapy in patients with biochemical relapse after radical prostatectomy Two years of bicalutamide monotherapy for BCR after RP should not be routinely recommended. Okubo, T., Mitsuzuka, K., Koie, T., et al. Jpn J Clin Oncol 2018 48:6 570–575, 10.1093/jjco/hyy060 Public Health Report Evidence-based cancer prevention recommendations for Japanese We evaluated the strength of evidence linking lifestyle factors and infection to the risk of cancer in Japan, and developed evidence-based cancer prevention recommendations applicable for Japanese people. Sasazuki, S., Inoue, M., Shimazu, T., et al. Jpn J Clin Oncol 2018 48:6 576–586, 10.1093/jjco/hyy048 Clinical Trial Note Evaluation of high-dose cytarabine in induction therapy for children with de novo acute myeloid leukemia: a study protocol of the Japan Children’s Cancer Group Multi-Center Seamless Phase II–III Randomized Trial (JPLSG AML-12) We are conducting a multi-center trial in Japan, which is a seamless Phase II–III study in previously untreated, newly diagnosed patients with acute myeloid leukemia at <18 years of age. Tomizawa, D., Tanaka, S., Hasegawa, D., et al. Jpn J Clin Oncol 2018 48:6 587–593, 10.1093/jjco/hyy061 Short Communication Effectiveness of a brief psycho-oncology training program for general nurses: a preliminary study A brief psycho-oncology training program improved general nurses’ confidence, knowledge and attitude regarding care for patients with normal psychological response after receiving bad news. Kubota, Y., Akechi, T., Okuyama, T. Jpn J Clin Oncol 2018 48:6 594–597, 10.1093/jjco/hyy059 Image of the Month Chemotherapy followed by gastric endoscopic submucosal dissection Kinoshita, S., Nishizawa, T., Banno, S., et al. Jpn J Clin Oncol 2018 48:6 598–599, 10.1093/jjco/hyy058 Cancer Statistics Digest
Japanese Journal of Clinical Oncology – Oxford University Press
Published: May 29, 2018
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