In Reply: Early Moderate Hyperoxemia does not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage

In Reply: Early Moderate Hyperoxemia does not Predict Outcome After Aneurysmal Subarachnoid... CORRESPONDENCE PaO2-load, to describe the exposure to hyperoxia. We consider In Reply: Early Moderate Hyperoxemia does this idea as truly interesting. We encourage Drs Shen and Du to not Predict Outcome After Aneurysmal investigate the usefulness of the PaO2-load. Subarachnoid Hemorrhage To the Editor: Disclosure We thank Drs Shen and Du for their valuable comments The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. about our article “Early Moderate Hyperoxemia Does Not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage.” ∗ ‡ Targeting hyperoxemia in a neurocritical care setting is Maarit Lång, MD common practice, but the safety of hyperoxemia has been Rahul Raj, MD, PhD questioned. In previous studies the definition, the cutoff value, Markus Benedikt Skrifvars, MD, PhD and time of assessment of hyperoxemia vary by study. Bellomo Matti Reinikainen, MD, PhD et al have shown that the worst PaO2 is more representative of Stepani Bendel, MD, PhD mean PaO2 than the first PaO2. Hyperoxia in the early phase of Department of Intensive Care Medicine, critical illness may be associated with worse outcome. However, Kuopio University Hospital, KYS, in most studies hyperoxia exposure is based on a single value of Kuopio, Finland PaO2. We wanted to study the mean exposure to oxygen and we Department of Intensive Care Medicine, chose TWA-O2 as an indicator for that. It has been previously Helsinki University Central Hospital, HUS, shown that there is a significant correlation between TWA-O2 Helsinki, Finland and nPaO2 and similar findings were discovered in our study as Department of Intensive Care Medicine, presented in Figure. Drs Shen and Du suggest a new index, the North Karelia Central Hospital, Joensuu, Finland Correspondence: Department of Intensive Care Medicine, Kuopio University Hospital, PO Box 100, 70029 Kys, Kuopio, Finland. E-mail: maarit.lang@kuh.fi REFERENCES 1. Du K, Shen Y. Letter: Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2017;80(5):E252. 2. Lång M, Raj R, Skrifvars MB, et al. Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2016;78(4):540-545. 3. Bellomo R, Bailey M, Eastwood GM, et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care. 2011;15(2):R90. 4. Damiani E, Adrario E, Girardis M, et al. Arterial hyperoxia and mortality in criti- cally ill patients: a systematic review and meta-analysis. Crit Care. 2014;18(6):711. 5. Raj R, Bendel S, Reinikainen M, et al. Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care. 2013;17(4):R177. 6. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818-829. FIGURE. The correlation between time-weighted average PaO2 and Apache II PaO2; PaO2: partial pressure of oxygen. 10.1093/neuros/nyx034 NEUROSURGERY VOLUME 80 | NUMBER 5 | MAY 2017 | E253 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

In Reply: Early Moderate Hyperoxemia does not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage

Free
1 page

Loading next page...
1 Page
 
/lp/ou_press/in-reply-early-moderate-hyperoxemia-does-not-predict-outcome-after-8C1670F049
Publisher
Congress of Neurological Surgeons
Copyright
Copyright © 2017 by the Congress of Neurological Surgeons
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1093/neuros/nyx034
Publisher site
See Article on Publisher Site

Abstract

CORRESPONDENCE PaO2-load, to describe the exposure to hyperoxia. We consider In Reply: Early Moderate Hyperoxemia does this idea as truly interesting. We encourage Drs Shen and Du to not Predict Outcome After Aneurysmal investigate the usefulness of the PaO2-load. Subarachnoid Hemorrhage To the Editor: Disclosure We thank Drs Shen and Du for their valuable comments The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. about our article “Early Moderate Hyperoxemia Does Not Predict Outcome After Aneurysmal Subarachnoid Hemorrhage.” ∗ ‡ Targeting hyperoxemia in a neurocritical care setting is Maarit Lång, MD common practice, but the safety of hyperoxemia has been Rahul Raj, MD, PhD questioned. In previous studies the definition, the cutoff value, Markus Benedikt Skrifvars, MD, PhD and time of assessment of hyperoxemia vary by study. Bellomo Matti Reinikainen, MD, PhD et al have shown that the worst PaO2 is more representative of Stepani Bendel, MD, PhD mean PaO2 than the first PaO2. Hyperoxia in the early phase of Department of Intensive Care Medicine, critical illness may be associated with worse outcome. However, Kuopio University Hospital, KYS, in most studies hyperoxia exposure is based on a single value of Kuopio, Finland PaO2. We wanted to study the mean exposure to oxygen and we Department of Intensive Care Medicine, chose TWA-O2 as an indicator for that. It has been previously Helsinki University Central Hospital, HUS, shown that there is a significant correlation between TWA-O2 Helsinki, Finland and nPaO2 and similar findings were discovered in our study as Department of Intensive Care Medicine, presented in Figure. Drs Shen and Du suggest a new index, the North Karelia Central Hospital, Joensuu, Finland Correspondence: Department of Intensive Care Medicine, Kuopio University Hospital, PO Box 100, 70029 Kys, Kuopio, Finland. E-mail: maarit.lang@kuh.fi REFERENCES 1. Du K, Shen Y. Letter: Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2017;80(5):E252. 2. Lång M, Raj R, Skrifvars MB, et al. Early moderate hyperoxemia does not predict outcome after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2016;78(4):540-545. 3. Bellomo R, Bailey M, Eastwood GM, et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care. 2011;15(2):R90. 4. Damiani E, Adrario E, Girardis M, et al. Arterial hyperoxia and mortality in criti- cally ill patients: a systematic review and meta-analysis. Crit Care. 2014;18(6):711. 5. Raj R, Bendel S, Reinikainen M, et al. Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care. 2013;17(4):R177. 6. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818-829. FIGURE. The correlation between time-weighted average PaO2 and Apache II PaO2; PaO2: partial pressure of oxygen. 10.1093/neuros/nyx034 NEUROSURGERY VOLUME 80 | NUMBER 5 | MAY 2017 | E253

Journal

NeurosurgeryOxford University Press

Published: May 1, 2017

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off