Abstract Context and Objective Severe hypoglycemic events are unevenly distributed in subjects with type 1 diabetes making a genetic influence probable. The adrenergic beta-2-receptor gene (ADRB2) has several common polymorphisms of which the Arg16 allele is associated with receptor down-regulation and reduced agonist-mediated endogenous glucose production. We tested the hypothesis that the Arg16 variant is associated with severe hypoglycaemia. Method A cohort of 311 subjects with type 1 diabetes reported severe hypoglycemic events retrospectively in a validated questionnaire. The subjects were characterized by diabetes history, state of hypoglycemia awareness (Clarke, Gold, and Hillerød methods), C-peptide status, hemoglobin A1c (HbA1c), and ADRB2 genotype. Results The ADRB2 Gly16Arg genotype distribution was in Hardy-Weinberg equilibrium. There was a difference in rate of severe hypoglycemia between all genotypes (P=0.01). Subjects homozygous for the Arg16 genotype (AA, n=60) had a relative rate of severe hypoglycemia of 2.2 (CI95 1.3-3.6) compared to subjects homozygous for the Gly16 genotype (GG, n=116) (P=0.002). Among subjects with impaired awareness or unawareness (n=175) those with the AA genotype (n=33) had a relative rate of severe hypoglycemia of 3.2 (CI95 1.7-6.0) compared to subjects with the GG genotype (n=58) (P<0.000). Genotype was not associated with state of hypoglycemia awareness per se as assessed by any of three classification methods. The difference was not explained by other risk factors (duration of diabetes, HbA1c, C-peptide). Conclusions Genetic polymorphism in the beta-2-receptor gene is associated with risk of severe hypoglycemia in individuals with type 1 diabetes, especially in those with impaired hypoglycemia awareness. Copyright © 2018 Endocrine Society
Journal of Clinical Endocrinology and Metabolism – Oxford University Press
Published: May 10, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera