Abstract Childhood diarrhea in low-resource settings has been variably linked to linear growth shortfalls. However, the association between etiology-specific diarrhea and growth has not been comprehensively evaluated. We tested diarrheal stools collected from the Performance of Rotavirus and Oral Polio Vaccines in Developing Countries study from 2011-2013 in Dhaka, Bangladesh by quantitative polymerase chain reaction for a broad range of enteropathogens to characterize diarrhea etiology and examine the association between etiology-specific diarrhea and linear growth and systemic inflammation. Pathogen-specific burdens of diarrhea were determined using attributable fractions. Linear regression was used to examine associations of pathogen-specific diarrhea with length-for-age z-scores (LAZ) and serum C-reactive protein. There was no relationship between all-cause diarrhea and length at 12 months (-0.01 change in 12-month LAZ per episode; 95% confidence interval: -0.06, 0.03). However, Cryptosporidium (-0.23 change in 12-month LAZ per attributable episode; 95% CI: -0.50, 0.03), Campylobacter jejuni/coli (-0.16; 95% CI: -0.32, -0.01) and Shigella/enteroinvasive E. coli diarrhea (-0.12; 95% CI: -0.26, 0.03) were associated with linear growth deficits. C. jejuni/coli and Shigella/enteroinvasive E. coli attributable diarrhea were associated with elevated C-reactive protein. The association between diarrhea and linear growth appears to be pathogen specific, reinforcing the need for pathogen-specific interventions. diarrhea, children, qPCR, growth, stunting © The Author(s) 2018. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
American Journal of Epidemiology – Oxford University Press
Published: May 15, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera