Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study

Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than... Abstract Background In HIV-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy. Methods A cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy, and with and without metabolic syndrome. Results Lipodystrophy was only associated with increased macrophage infiltration (P=0.04) and adiponectin mRNA (P=0.008), whereas metabolic syndrome was associated with larger adipocytes (P<0.0001), decreased expression of genes related to adipogenesis and adipocyte function (P-values between <0.0001-0.08), increased leptin mRNA (P=0.04), and a trend towards increased expression of inflammatory genes (P-values between 0.08-0.6). Conclusions Metabolic syndrome rather than lipodystrophy was associated with major unfavourable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardio-metabolic complications. Lipodystrophy, metabolic syndrome, adipose tissue, HIV-infection © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Infectious Diseases Oxford University Press

Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study

Download PDF
29 pages
Read Article

Loading next page...
 
/lp/ou_press/histological-and-molecular-adipose-tissue-changes-are-related-to-OkfeZN1QSY
Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1093/infdis/jiy284
Publisher site
See Article on Publisher Site

Abstract

Abstract Background In HIV-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy. Methods A cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy, and with and without metabolic syndrome. Results Lipodystrophy was only associated with increased macrophage infiltration (P=0.04) and adiponectin mRNA (P=0.008), whereas metabolic syndrome was associated with larger adipocytes (P<0.0001), decreased expression of genes related to adipogenesis and adipocyte function (P-values between <0.0001-0.08), increased leptin mRNA (P=0.04), and a trend towards increased expression of inflammatory genes (P-values between 0.08-0.6). Conclusions Metabolic syndrome rather than lipodystrophy was associated with major unfavourable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardio-metabolic complications. Lipodystrophy, metabolic syndrome, adipose tissue, HIV-infection © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

The Journal of Infectious Diseases – Oxford University Press

Published: May 17, 2018

References

  • A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
    Carr
  • Fat distribution evaluated by computed tomography and metabolic abnormalities in patients undergoing antiretroviral therapy: preliminary results of the LIPOCO study
    Saint-Marc
  • Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: prevalence and metabolic consequences
    Hammond
  • Contribution of nucleoside-analogue reverse transcriptase inhibitor therapy to lipoatrophy from the population to the cellular level
    Nolan
  • HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy
    Giralt
  • HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes
    Díaz-Delfín
  • Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population
    Hansen
  • The associations of regional adipose tissue with lipid and lipoprotein levels in HIV-infected men
    Wohl
  • A comprehensive review on metabolic syndrome
    Kaur
  • A meta-analysis of the metabolic syndrome prevalence in the global HIV-infected population
    Nguyen
  • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    Alberti
  • Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy
    Sevastianova
  • Gene expression and immunohistochemistry in adipose tissue of HIV type 1-infected patients with nucleoside analogue reverse-transcriptase inhibitor-associated lipoatrophy
    Sievers
  • Adipose tissue dysregulation in patients with metabolic syndrome
    Bremer
  • Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy
    Vigouroux
  • Evolving perspectives on HIV-associated lipodystrophy syndrome: moving from lipodystrophy to non-infectious HIV co-morbidities
    Guaraldi
  • Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients
    Jan
  • Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance
    Bastard
  • FoxO1, the transcriptional chief of staff of energy metabolism
    Kousteni
  • Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
    de Kreutzenberg
  • A putative role for endogenous FGF-2 in FGF-1 mediated differentiation of human preadipocytes
    Hutley
  • Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice
    Liu
  • Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
    Kwon
  • Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
    Mayoral
  • Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women
    Pedersen
  • Resveratrol improves health and survival of mice on a high-calorie diet
    Baur
  • The ups and downs of SIRT1
    Kwon
  • De novo formation of adipose tissue by controlled release of basic fibroblast growth factor
    Tabata
  • Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice
    Shan
  • Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
    He
  • Assessment of in situ adipose tissue inflammation by microdialysis
    Langkilde
  • Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls
    Langkilde
  • Immunosenescence of the CD8(+) T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls
    Tavenier
  • Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function
    Andersen
  • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    Matthews
  • Long-term high-physiological-dose growth hormone reduces intra-abdominal fat in HIV-infected patients with a neutral effect on glucose metabolism
    Hansen
  • Dual Energy X-Ray absorptiometry body composition reference values from NHANES
    Kelly
  • Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy
    Nolan
  • Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance
    Weyer
  • The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity
    Salans
  • Relationship between adipocyte size and adipokine expression and secretion
    Skurk
  • Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia
    Couillard
  • Differentially altered molecular signature of visceral adipose tissue in HIV-1-associated lipodystrophy
    Gallego-Escuredo
  • Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity
    Wentworth
  • Obesity is associated with macrophage accumulation in adipose tissue
    Weisberg
  • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    Cinti
  • Human adipose tissue as a reservoir for memory CD4+ T cells and HIV
    Couturier
  • Adipose tissue is enriched for activated and late-differentiated CD8+ T cells and shows distinct CD8+ receptor usage, compared with blood in HIV-infected persons
    Koethe
  • Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection
    Damouche

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial